about
Potent inhibitors of a shikimate pathway enzyme from Mycobacterium tuberculosis: combining mechanism- and modeling-based designThe Prodrug Approach: A Successful Tool for Improving Drug SolubilitySynthesis of nucleoside phosphate and phosphonate prodrugsRational Design, Synthesis, and Evaluation of New Selective Inhibitors of Microbial Class II (Zinc Dependent) Fructose Bis-phosphate AldolasesSecond-generation probes for biosynthetic intermediate capture: towards a comprehensive profiling of polyketide assemblyPlasma membrane phosphoinositide balance regulates cell shape during Drosophila embryo morphogenesis.Chemical validation of GPI biosynthesis as a drug target against African sleeping sickness.Aryl phosphoramidates of 5-phospho erythronohydroxamic acid, a new class of potent trypanocidal compounds.Inositol pentakisphosphate isomers bind PH domains with varying specificity and inhibit phosphoinositide interactionsEnantiomerically pure phosphonated carbocyclic 2'-oxa-3'-azanucleosides: synthesis and biological evaluation.Evaluating prodrug strategies for esterase-triggered release of alcoholsAntibacterial and antitubercular activity of fosmidomycin, FR900098, and their lipophilic analogs.Inositol polyphosphate derivative inhibits Na+ transport and improves fluid dynamics in cystic fibrosis airway epithelia.Rp-cAMPS Prodrugs Reveal the cAMP Dependence of First-Phase Glucose-Stimulated Insulin Secretion.Potent and selective phosphopeptide mimetic prodrugs targeted to the Src homology 2 (SH2) domain of signal transducer and activator of transcription 3.Interaction of nucleic acids with the glycocalyxRibonuclease-Activated Cancer Prodrug.Can intervention in inositol phosphate signalling pathways improve therapy for cystic fibrosis?Synthesis and biological evaluation of phosphate prodrugs of 4-phospho-D-erythronohydroxamic acid, an inhibitor of 6-phosphogluconate dehydrogenase.5'-Phosphate and 5'-phosphonate ester derivatives of (N)-methanocarba adenosine with in vivo cardioprotective activityMono-anionic phosphopeptides produced by unexpected histidine alkylation exhibit high Plk1 polo-box domain-binding affinities and enhanced antiproliferative effects in HeLa cells.An expanded biological repertoire for Ins(3,4,5,6)P4 through its modulation of ClC-3 function.Design and synthesis of a reagent for solid-phase incorporation of the phosphothreonine mimetic (2S,3R)-2-amino-3-methyl-4-phosphonobutyric acid (Pmab) into peptides in a bio-reversible phosphonyl-bis-pivaloyloxymethyl (POM) prodrug form.Peptide-based inhibitors of Plk1 polo-box domain containing mono-anionic phosphothreonine esters and their pivaloyloxymethyl prodrugs.Structure-Activity Studies of Phosphopeptidomimetic Prodrugs Targeting the Src Homology 2 (SH2) Domain of Signal Transducer and Activator of Transcription 3 (Stat3).MEPicides: potent antimalarial prodrugs targeting isoprenoid biosynthesis.Medicinal Chemistry of the Noncanonical Cyclic Nucleotides cCMP and cUMP.Structure-Activity Relationships of the MEPicides: N-Acyl and O-Linked Analogs of FR900098 as Inhibitors of Dxr from Mycobacterium tuberculosis and Yersinia pestis.Chemical tools for interrogating inositol pyrophosphate structure and function.1-Amino-3-(1H-1,2,3-triazol-1-yl)propylphosphonates as acyclic analogs of nucleotides.Photoactivatable and cell-membrane-permeable phosphatidylinositol 3,4,5-trisphosphate.Nicotinic acid adenine dinucleotide phosphate (NAADP) is a second messenger in muscarinic receptor-induced contraction of guinea pig trachea.2'-C-Methyl branched pyrimidine ribonucleoside analogues: potent inhibitors of RNA virus replication.Molecular tools for cell and systems biology.Synthesis and utility of fluorogenic acetoxymethyl ethers.Efficient synthesis of nucleoside aryloxy phosphoramidate prodrugs utilizing benzyloxycarbonyl protection.In vitro evaluation of 9-(2-phosphonylmethoxyethyl)adenine ester analogues, a series of anti-HBV structures with improved plasma stability and liver release.Efficient synthesis of exo-N-carbamoyl nucleosides: application to the synthesis of phosphoramidate prodrugs.Simultaneous bioanalysis of a phosphate prodrug and its parent compound using a multiplexed LC-MS method.Synthesis of phosphoramidate prodrugs: ProTide approach.
P2860
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P2860
description
2003 nî lūn-bûn
@nan
2003 թուականի Մարտին հրատարակուած գիտական յօդուած
@hyw
2003 թվականի մարտին հրատարակված գիտական հոդված
@hy
2003年の論文
@ja
2003年論文
@yue
2003年論文
@zh-hant
2003年論文
@zh-hk
2003年論文
@zh-mo
2003年論文
@zh-tw
2003年论文
@wuu
name
Prodrugs of biologically active phosphate esters.
@ast
Prodrugs of biologically active phosphate esters.
@en
type
label
Prodrugs of biologically active phosphate esters.
@ast
Prodrugs of biologically active phosphate esters.
@en
prefLabel
Prodrugs of biologically active phosphate esters.
@ast
Prodrugs of biologically active phosphate esters.
@en
P1476
Prodrugs of biologically active phosphate esters.
@en
P2093
Carsten Schultz
P304
P356
10.1016/S0968-0896(02)00552-7
P407
P577
2003-03-01T00:00:00Z