Disulfiram reactivates latent HIV-1 in a Bcl-2-transduced primary CD4+ T cell model without inducing global T cell activation. - Wikidata - awgldk - TriplyDB

Disulfiram reactivates latent HIV-1 in a Bcl-2-transduced primary CD4+ T cell model without inducing global T cell activation.

Disulfiram reactivates latent HIV-1 in a Bcl-2-transduced primary CD4+ T cell model without inducing global T cell activation.

http://www.wikidata.org/entity/Q35077057

about

Recent Advances in Lentiviral Vaccines for HIV-1 Infection Epigenetic control of HIV-1 post integration latency: implications for therapy HIV-1 eradication strategies: design and assessment HIV-1 functional cure: will the dream come true?Recent developments in human immunodeficiency virus-1 latency research Multi-dose Romidepsin Reactivates Replication Competent SIV in Post-antiretroviral Rhesus Macaque Controllers Ongoing Clinical Trials of Human Immunodeficiency Virus Latency-Reversing and Immunomodulatory Agents Histone deacetylase inhibitor romidepsin induces HIV expression in CD4 T cells from patients on suppressive antiretroviral therapy at concentrations achieved by clinical dosing.Nanoscale Reaction Vessels Designed for Synthesis of Copper-Drug Complexes Suitable for Preclinical Development Predicting the outcomes of treatment to eradicate the latent reservoir for HIV-1 Prospects for treatment of latent HIV.Differential penetration of raltegravir throughout gastrointestinal tissue: implications for eradication and cure.Targeting TNF and TNF Receptor Pathway in HIV-1 Infection: from Immune Activation to Viral Reservoirs Benzotriazoles Reactivate Latent HIV-1 through Inactivation of STAT5 SUMOylation.Entinostat is a histone deacetylase inhibitor selective for class 1 histone deacetylases and activates HIV production from latently infected primary T cells.Novel exosome-targeted T-cell-based vaccine counteracts T-cell anergy and converts CTL exhaustion in chronic infection via CD40L signaling through the mTORC1 pathway Novel structurally related compounds reactivate latent HIV-1 in a bcl-2-transduced primary CD4+ T cell model without inducing global T cell activation.Comparative analysis of measures of viral reservoirs in HIV-1 eradication studies Towards an HIV cure: a global scientific strategy Combinatorial anti-HIV gene therapy: using a multipronged approach to reach beyond HAART Administration of a Toll-like receptor 9 agonist decreases the proviral reservoir in virologically suppressed HIV-infected patients.Rapid quantification of the latent reservoir for HIV-1 using a viral outgrowth assay Exploring the potential of monoclonal antibody therapeutics for HIV-1 eradication.Attenuated Listeria monocytogenes vectors overcome suppressive plasma factors during HIV infection to stimulate myeloid dendritic cells to promote adaptive immunity and reactivation of latent virus.Gag-positive reservoir cells are susceptible to HIV-specific cytotoxic T lymphocyte mediated clearance in vitro and can be detected in vivo [corrected]HIV-1 transcriptional regulation in the central nervous system and implications for HIV cure research Measuring turnover of SIV DNA in resting CD4+ T cells using pyrosequencing: implications for the timing of HIV eradication therapies Dynamics of HIV latency and reactivation in a primary CD4+ T cell model.A primary CD4(+) T cell model of HIV-1 latency established after activation through the T cell receptor and subsequent return to quiescence Post-treatment control of HIV infection.Ex vivo analysis identifies effective HIV-1 latency-reversing drug combinations.Apoptosis-induced activation of HIV-1 in latently infected cell lines Activation and lysis of human CD4 cells latently infected with HIV-1 Synergistic Activation of Latent HIV-1 Expression by Novel Histone Deacetylase Inhibitors and Bryostatin-1.FACT Proteins, SUPT16H and SSRP1, Are Transcriptional Suppressors of HIV-1 and HTLV-1 That Facilitate Viral Latency Human immunodeficiency virus (HIV) latency: the major hurdle in HIV eradication Concurrent measures of total and integrated HIV DNA monitor reservoirs and ongoing replication in eradication trials Stimulation of HIV-1-specific cytolytic T lymphocytes facilitates elimination of latent viral reservoir after virus reactivation.HIV-1 latency and virus production from unintegrated genomes following direct infection of resting CD4 T cells.Potential of Radiation-Induced Cellular Stress for Reactivation of Latent HIV-1 and Killing of Infected Cells

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Disulfiram reactivates latent HIV-1 in a Bcl-2-transduced primary CD4+ T cell model without inducing global T cell activation.

http://www.wikidata.org/entity/Q35077057

description

2011 nî lūn-bûn

@nan

2011 թուականի Ապրիլին հրատարակուած գիտական յօդուած

@hyw

2011 թվականի ապրիլին հրատարակված գիտական հոդված

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2011年の論文

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2011年学术文章

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2011年学术文章

@zh-cn

2011年学术文章

@zh-hans

2011年学术文章

@zh-my

2011年学术文章

@zh-sg

2011年學術文章

@yue

name

Disulfiram reactivates latent ...... cing global T cell activation.

@ast

Disulfiram reactivates latent ...... cing global T cell activation.

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type

label

Disulfiram reactivates latent ...... cing global T cell activation.

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Disulfiram reactivates latent ...... cing global T cell activation.

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prefLabel

Disulfiram reactivates latent ...... cing global T cell activation.

@ast

Disulfiram reactivates latent ...... cing global T cell activation.

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P1433

Journal of Virology

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Disulfiram reactivates latent ...... cing global T cell activation.

@en

P2093

Cynthia K Bullen

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Hao Zhang

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Janet D Siliciano

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Jordyn L Manucci

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Liang Shan

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Neeta S Shroff

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Shridhar Bhat

http://www.w3.org/2001/XMLSchema#string

Sifei Xing

http://www.w3.org/2001/XMLSchema#string

P2860

Suberoylanilide hydroxamic acid reactivates HIV from latently infected cells

Identification of a reservoir for HIV-1 in patients on highly active antiretroviral therapy

Presence of an inducible HIV-1 latent reservoir during highly active antiretroviral therapy

Recovery of replication-competent HIV despite prolonged suppression of plasma viremia

Quantification of latent tissue reservoirs and total body viral load in HIV-1 infection

Small-molecule screening using a human primary cell model of HIV latency identifies compounds that reverse latency without cellular activation

Elimination kinetics of disulfiram in alcoholics after single and repeated doses.

Molecular characterization, reactivation, and depletion of latent HIV.

A review of the pharmacokinetics and pharmacodynamics of disulfiram and its metabolites.

Disulfiram, an old drug with new potential therapeutic uses for human cancers and fungal infections.

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6060-6064

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scholarly article

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10.1128/JVI.02033-10

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P433

12

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P478

85

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David M. Margolis

Robert F. Siliciano

Joseph B Margolick

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2011-04-06T00:00:00Z

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21471244

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P932

3126325

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