BH3-only proteins that bind pro-survival Bcl-2 family members fail to induce apoptosis in the absence of Bax and Bak - Wikidata - awgldk - TriplyDB

BH3-only proteins that bind pro-survival Bcl-2 family members fail to induce apoptosis in the absence of Bax and Bak

BH3-only proteins that bind pro-survival Bcl-2 family members fail to induce apoptosis in the absence of Bax and Bak

http://www.wikidata.org/entity/Q35079498

about

Hypoxia and defective apoptosis drive genomic instability and tumorigenesis Involvement of Noxa in cellular apoptotic responses to interferon, double-stranded RNA, and virus infection Identification of novel isoforms of the BH3 domain protein Bim which directly activate Bax to trigger apoptosis Human Bop is a novel BH3-only member of the Bcl-2 protein family Human nuclear clusterin mediates apoptosis by interacting with Bcl-XL through C-terminal coiled coil domain Proapoptotic Bak is sequestered by Mcl-1 and Bcl-xL, but not Bcl-2, until displaced by BH3-only proteins.ASC is a Bax adaptor and regulates the p53-Bax mitochondrial apoptosis pathway PUMA Dissociates Bax and Bcl-X(L) to induce apoptosis in colon cancer cells Clusterin inhibits apoptosis by interacting with activated Bax Mitochondrial carrier homolog 2 is a target of tBID in cells signaled to die by tumor necrosis factor alpha.The Bax subfamily of Bcl2-related proteins is essential for apoptotic signal transduction by c-Jun NH(2)-terminal kinase Development, migration, and survival of mast cells PUMA mediates the apoptotic response to p53 in colorectal cancer cells JNK phosphorylation of Bim-related members of the Bcl2 family induces Bax-dependent apoptosis Suppression of tumorigenesis by the p53 target PUMA The Bcl-2 apoptotic switch in cancer development and therapy PUMA regulates intestinal progenitor cell radiosensitivity and gastrointestinal syndrome BH3 mimetics to improve cancer therapy; mechanisms and examples Proapoptotic BH3-only proteins trigger membrane integration of prosurvival Bcl-w and neutralize its activity Puma cooperates with Bim, the rate-limiting BH3-only protein in cell death during lymphocyte development, in apoptosis induction Induction of cell death by the BH3-only Bcl-2 homolog Nbk/Bik is mediated by an entirely Bax-dependent mitochondrial pathway The structure of Bcl-w reveals a role for the C-terminal residues in modulating biological activity The pro-apoptotic Bcl-2 family member tBid localizes to mitochondrial contact sites A surface groove essential for viral Bcl-2 function during chronic infection in vivo.Regulation of Bim in Health and Disease BH3 profiling--measuring integrated function of the mitochondrial apoptotic pathway to predict cell fate decisions Novel immunotherapeutic strategies of gastric cancer treatment Mitochondria and mitophagy: the yin and yang of cell death control BH3 peptides induce mitochondrial fission and cell death independent of BAX/BAK A novel BH3 ligand that selectively targets Mcl-1 reveals that apoptosis can proceed without Mcl-1 degradation Discovery and molecular characterization of a Bcl-2-regulated cell death pathway in schistosomes The restricted binding repertoire of Bcl-B leaves Bim as the universal BH3-only prosurvival Bcl-2 protein antagonist Bcl2 Family Functions as Signaling Target in Nicotine-/NNK-Induced Survival of Human Lung Cancer Cells.ER Stress-Mediated Signaling: Action Potential and Ca(2+) as Key Players Humanin binds and nullifies Bid activity by blocking its activation of Bax and Bak BH-3-only BIK functions at the endoplasmic reticulum to stimulate cytochrome c release from mitochondria FoxO3a transcriptional regulation of Bim controls apoptosis in paclitaxel-treated breast cancer cell lines The proapoptotic BH3-only protein BAD transduces cell death signals independently of its interaction with Bcl-2 A genome-wide RNAi screen reveals multiple regulators of caspase activation Regulation of mitochondrial ceramide distribution by members of the BCL-2 family

P2860

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P2860

BH3-only proteins that bind pro-survival Bcl-2 family members fail to induce apoptosis in the absence of Bax and Bak

http://www.wikidata.org/entity/Q35079498

description

2001 nî lūn-bûn

@nan

2001 թուականի Յունիսին հրատարակուած գիտական յօդուած

@hyw

2001 թվականի հունիսին հրատարակված գիտական հոդված

@hy

2001年の論文

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2001年論文

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2001年論文

@zh-hant

2001年論文

@zh-hk

2001年論文

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2001年論文

@zh-tw

2001年论文

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name

BH3-only proteins that bind pr ...... in the absence of Bax and Bak

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BH3-only proteins that bind pr ...... in the absence of Bax and Bak

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BH3-only proteins that bind pr ...... in the absence of Bax and Bak

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BH3-only proteins that bind pr ...... in the absence of Bax and Bak

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BH3-only proteins that bind pr ...... in the absence of Bax and Bak

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BH3-only proteins that bind pr ...... in the absence of Bax and Bak

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P1433

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P1433

Genes & Development

P1476

BH3-only proteins that bind pr ...... in the absence of Bax and Bak

@en

P2093

A J Ross

http://www.w3.org/2001/XMLSchema#string

C B Thompson

http://www.w3.org/2001/XMLSchema#string

G R MacGregor

http://www.w3.org/2001/XMLSchema#string

T Lindsten

http://www.w3.org/2001/XMLSchema#string

W X Zong

http://www.w3.org/2001/XMLSchema#string

P2860

Bax interacts with the permeability transition pore to induce permeability transition and cytochrome c release in isolated mitochondria

tBID, a membrane-targeted death ligand, oligomerizes BAK to release cytochrome c

PUMA induces the rapid apoptosis of colorectal cancer cells

PUMA, a novel proapoptotic gene, is induced by p53

Bid, a Bcl2 interacting protein, mediates cytochrome c release from mitochondria in response to activation of cell surface death receptors

Cleavage of BID by caspase 8 mediates the mitochondrial damage in the Fas pathway of apoptosis

Bad, a heterodimeric partner for Bcl-XL and Bcl-2, displaces Bax and promotes cell death

Bim: a novel member of the Bcl-2 family that promotes apoptosis

Conformation of the Bax C-terminus regulates subcellular location and cell death

Bok is a pro-apoptotic Bcl-2 protein with restricted expression in reproductive tissues and heterodimerizes with selective anti-apoptotic Bcl-2 family members

P304

1481-1486

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scholarly article

P356

10.1101/GAD.897601

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12

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P478

15

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P577

2001-06-01T00:00:00Z

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11928563

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11410528

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312722

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