Longevity effect of IGF-1R(+/-) mutation depends on genetic background-specific receptor activation. - Wikidata - awgldk - TriplyDB

Longevity effect of IGF-1R(+/-) mutation depends on genetic background-specific receptor activation.

Longevity effect of IGF-1R(+/-) mutation depends on genetic background-specific receptor activation.

http://www.wikidata.org/entity/Q35080440

about

Minireview: The Complexities of IGF/Insulin Signaling in Aging: Why Flies and Worms Are Not Humans The somatotropic axis and longevity in mice Genome-wide association mapping of acute lung injury in neonatal inbred mice Herbal supplement extends life span under some environmental conditions and boosts stress resistance Syntaxin 4 Overexpression Ameliorates Effects of Aging and High-Fat Diet on Glucose Control and Extends Lifespan Nordihydroguaiaretic Acid Extends the Lifespan of Drosophila and Mice, Increases Mortality-Related Tumors and Hemorrhagic Diathesis, and Alters Energy Homeostasis in Mice.The Alzheimer's disease transcriptome mimics the neuroprotective signature of IGF-1 receptor-deficient neurons.Deletion of IGF-1 Receptors in Cardiomyocytes Attenuates Cardiac Aging in Male Mice.The somatotropic axis and aging: Benefits of endocrine defects.The Somatotropic Axis in Human Aging: Framework for the Current State of Knowledge and Future Research Evaluating Health Span in Preclinical Models of Aging and Disease: Guidelines, Challenges, and Opportunities for Geroscience.Paternal Insulin-like Growth Factor 2 (Igf2) Regulates Stem Cell Activity During Adulthood.Causes and consequences of genetic background effects illuminated by integrative genomic analysis.Insulin-like growth factor 1 receptor regulates hypothermia during calorie restriction.Growth factor, energy and nutrient sensing signalling pathways in metabolic ageing.Sex-Specific Gene Expression and Life Span Regulation.Can aging be 'drugged'?The metabolic regulation of aging.Life-span Extension With Reduced Somatotrophic Signaling: Moderation of Aging Effect by Signal Type, Sex, and Experimental Cohort.Life history evolution, reproduction, and the origins of sex-dependent aging and longevity.Different Mechanisms of Longevity in Long-Lived Mouse and Caenorhabditis elegans Mutants Revealed by Statistical Analysis of Mortality Rates.Sex differences in lifespan extension with acarbose and 17-α estradiol: gonadal hormones underlie male-specific improvements in glucose tolerance and mTORC2 signaling.Deleting IGF-1 receptor from forebrain neurons confers neuroprotection during stroke and upregulates endocrine somatotropin.IGF-1 has sexually dimorphic, pleiotropic, and time-dependent effects on healthspan, pathology, and lifespan.Late-life targeting of the IGF-1 receptor improves healthspan and lifespan in female mice.

P2860

Q28085566-3BC70525-7501-47F7-A851-A4F32F709145 Q28088532-6C677B75-4823-41A8-924C-490E6A32DF70 Q33613229-550889C0-20A2-4BB8-B5D9-61145E24C74D Q35448688-A404B756-FC11-455E-B056-CCB66AF77CED Q36030232-6271CF0F-EA9C-4D5E-A64C-E36254B7C096 Q36243410-B5A50427-6398-4E2D-B91C-E9CD3D11C8BF Q36396128-7D5A5E51-5ADE-47DD-8799-8AE3D64E908D Q36431795-460EE0DF-42D7-466D-80EB-CAF190F419A3 Q36689258-D8F0A8C2-7464-4208-93C2-0185592FB3AB Q37035744-88624A10-1238-491A-8B99-A9C736598910 Q37322066-679980FB-94F7-400E-8CF8-7A54DD3753C6 Q37584284-267C449E-6C99-4526-B125-10C4FA4CD4AC Q37696381-A5153D4F-52F9-45E8-9D58-DED22F729EC0 Q38615454-9039E791-53EA-4D4C-B658-79DDC4C70020 Q38631149-A113AE1A-15C1-48B8-ACB3-53DD845D8C0B Q38639082-F8F63EC9-45C0-47F0-BDC6-AFCE07B3E8FB Q38662550-C840E0BF-58ED-47CA-A473-1391E0025E7D Q38662555-D715A096-3067-4304-86F3-11898E79EAFB Q38957810-34CC2B0E-EAFA-4736-B82E-6CD50324467D Q39051354-39568530-D7F2-4833-89C1-2CCCA6D7A20A Q42628444-B7A134E0-1E59-4304-8634-5CBD1920A100 Q47141522-16CA4E09-3740-4AC4-9B82-769528271ADD Q50546416-C884725D-0315-4A96-B89B-CB5A0B967DE7 Q54405530-5979CDEA-8F18-4E15-A294-46F3886C3827 Q55318581-085FCFEE-16F4-4061-9ED5-CD3413D03872

P2860

Longevity effect of IGF-1R(+/-) mutation depends on genetic background-specific receptor activation.

http://www.wikidata.org/entity/Q35080440

description

2013 nî lūn-bûn

@nan

2013 թուականի Սեպտեմբերին հրատարակուած գիտական յօդուած

@hyw

2013 թվականի սեպտեմբերին հրատարակված գիտական հոդված

@hy

2013年の論文

@ja

2013年論文

@yue

2013年論文

@zh-hant

2013年論文

@zh-hk

2013年論文

@zh-mo

2013年論文

@zh-tw

2013年论文

@wuu

name

Longevity effect of IGF-1R(+/- ...... -specific receptor activation.

@ast

Longevity effect of IGF-1R(+/- ...... -specific receptor activation.

@en

type

label

Longevity effect of IGF-1R(+/- ...... -specific receptor activation.

@ast

Longevity effect of IGF-1R(+/- ...... -specific receptor activation.

@en

prefLabel

Longevity effect of IGF-1R(+/- ...... -specific receptor activation.

@ast

Longevity effect of IGF-1R(+/- ...... -specific receptor activation.

@en

P1433

Q35080440-C5CE2272-6780-425E-B868-C15A3D8A4346

P1476

Q35080440-9FAC8C65-7F5A-4692-A6E7-285BADD72B6C

P2093

Q35080440-2FEC8073-52FA-481E-B8A2-954FAB589F58

Q35080440-4A5CB270-BD33-420E-BCA9-5B6E1BAEFC7D

Q35080440-50269691-2B07-4DAB-95B2-95208F7F0ED2

Q35080440-6668D108-A26A-4958-B545-4657BDA8152A

Q35080440-AC127165-E0DC-47D0-B04F-DDF7A9A3BB6D

Q35080440-FD3D2AEB-357C-4605-89F9-567AF6389616

P2860

Q35080440-068AC27F-DEAB-4BD1-834B-98FCB8F80E11

Q35080440-06DBC31F-28E3-47C4-B306-9A1D23662959

Q35080440-06FA7F7A-51DA-4BBA-BFAF-57A3AC81EBE5

Q35080440-08EAAA4E-A3D9-4BCC-82E0-6C9306136EEB

Q35080440-0A5293CB-859C-4449-A899-CAC99875A3DA

Q35080440-0FAC22D5-3FCF-4F53-BE23-FFE78F3E7EA9

Q35080440-1BA55211-074B-41FE-93DB-91BD50AF2786

Q35080440-2814B2D0-B6AE-43EA-B071-D3360B5773FF

Q35080440-2A84187F-5802-4703-A26B-AB7A04761FB9

Q35080440-2A989E1F-6DBD-4A2F-B4CF-A60888EF5F76

P304

Q35080440-D517FD73-2C25-4C40-BED7-9E982EFD216B

P31

Q35080440-2FDC9454-F930-4D03-A435-C8C3CD103D43

P356

Q35080440-EE5ABC3A-30FF-40BB-BD5E-3D0240B48DB2

P433

Q35080440-904F2EB4-9356-4B5F-AFEF-4DD08739FECA

P478

Q35080440-686B338B-ABDA-4BAB-A0BA-27A2647BD45F

P577

Q35080440-4CC04229-8A91-4942-BDC9-38556FB7B85D

P5875

Q35080440-8C890570-CA29-402F-B072-0F2E12E222CB

P698

Q35080440-794EAE16-B98E-4F58-9AA8-B576D28EFD26

P932

Q35080440-9355D240-C563-4FAB-A1D4-B5154869B60A

P356

P1433

P1476

Longevity effect of IGF-1R(+/- ...... -specific receptor activation.

@en

P2093

Géraldine Gontier

http://www.w3.org/2001/XMLSchema#string

Jie Xu

http://www.w3.org/2001/XMLSchema#string

Joëlle Dupont

http://www.w3.org/2001/XMLSchema#string

Martin Holzenberger

http://www.w3.org/2001/XMLSchema#string

Philippe Lacube

http://www.w3.org/2001/XMLSchema#string

Zayna Chaker

http://www.w3.org/2001/XMLSchema#string

P2860

Role of the GH/IGF-1 axis in lifespan and healthspan: lessons from animal models.

Association of FOXO3A variation with human longevity confirmed in German centenarians

FOXO3A genotype is strongly associated with human longevity

Deficiency in type 1 insulin-like growth factor receptor in mice protects against oxygen-induced lung injury

Does reduced IGF-1R signaling in Igf1r+/- mice alter aging?

Brain IGF-1 receptors control mammalian growth and lifespan through a neuroendocrine mechanism

Evidence for lifespan extension and delayed age-related biomarkers in insulin receptor substrate 1 null mice

Lifespan extension and delayed immune and collagen aging in mutant mice with defects in growth hormone production

Effects of mutations in the insulin-like growth factor signaling system on embryonic pancreas development and beta-cell compensation to insulin resistance

Liver-derived IGF-I regulates mean life span in mice

P304

19-28

http://www.w3.org/2001/XMLSchema#string

P31

scholarly article

P356

10.1111/ACEL.12145

http://www.w3.org/2001/XMLSchema#string

P433

1

http://www.w3.org/2001/XMLSchema#string

P478

13

http://www.w3.org/2001/XMLSchema#string

P577

2013-09-11T00:00:00Z

http://www.w3.org/2001/XMLSchema#dateTime

P5875

253646640

http://www.w3.org/2001/XMLSchema#string

P698

23898955

http://www.w3.org/2001/XMLSchema#string

P932

4326867

http://www.w3.org/2001/XMLSchema#string