Critical role of proteostasis-imbalance in pathogenesis of COPD and severe emphysema - Wikidata - awgldk - TriplyDB

Critical role of proteostasis-imbalance in pathogenesis of COPD and severe emphysema

Critical role of proteostasis-imbalance in pathogenesis of COPD and severe emphysema

http://www.wikidata.org/entity/Q35083187

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Histone deacetylase inhibitor (HDACi) suberoylanilide hydroxamic acid (SAHA)-mediated correction of α1-antitrypsin deficiency Experimental Evidence Shows Salubrinal, an eIF2α Dephosphorylation Inhibitor, Reduces Xenotoxicant-Induced Cellular Damage Is there a therapeutic role for selenium in alpha-1 antitrypsin deficiency?Accumulation of ubiquitin and sequestosome-1 implicate protein damage in diacetyl-induced cytotoxicity Nrf2 expression is increased in peripheral blood mononuclear cells derived from mild-moderate ex-smoker COPD patients with persistent oxidative stress Identification and characterization of PERK activators by phenotypic screening and their effects on NRF2 activation Second-hand cigarette smoke impairs bacterial phagocytosis in macrophages by modulating CFTR dependent lipid-rafts Dendrimer-Based Selective Proteostasis-Inhibition Strategy to Control NSCLC Growth and Progression RNAi Screen for NRF2 Inducers Identifies Targets That Rescue Primary Lung Epithelial Cells from Cigarette Smoke Induced Radical Stress Malfolded protein structure and proteostasis in lung diseases.Histone deacetylase 6-mediated selective autophagy regulates COPD-associated cilia dysfunction.Metabolomic profiling in a Hedgehog Interacting Protein (Hhip) murine model of chronic obstructive pulmonary disease.Role of Cigarette Smoke-Induced Aggresome Formation in Chronic Obstructive Pulmonary Disease-Emphysema Pathogenesis Critical role of VCP/p97 in the pathogenesis and progression of non-small cell lung carcinoma.Genes related to emphysema are enriched for ubiquitination pathways.Induction of the unfolded protein response by cigarette smoke is primarily an activating transcription factor 4-C/EBP homologous protein mediated process Critical role of CFTR-dependent lipid rafts in cigarette smoke-induced lung epithelial injury.Activation of the UPR protects against cigarette smoke-induced RPE apoptosis through up-regulation of Nrf2.Regulation of immunoproteasome function in the lung.Proteasome function is not impaired in healthy aging of the lung.Cervical Cancer Cell Line Secretome Highlights the Roles of Transforming Growth Factor-Beta-Induced Protein ig-h3, Peroxiredoxin-2, and NRF2 on Cervical Carcinogenesis.Airway Exposure to E-Cigarette Vapors Impairs Autophagy and Induces Aggresome Formation.Role of p97/VCP (Cdc48) in genome stability.Valosin-containing protein (VCP) promotes the growth, invasion, and metastasis of colorectal cancer through activation of STAT3 signaling Involvement of B-cell CLL/lymphoma 2 promoter methylation in cigarette smoke extract-induced emphysema.The emerging role of the ubiquitin proteasome in pulmonary biology and disease.Role of second-hand smoke (SHS)-induced proteostasis/autophagy impairment in pediatric lung diseases.The interplay between endoplasmic reticulum stress and inflammation.Autophagy: a critical regulator of cellular metabolism and homeostasis.Autophagy: a crucial moderator of redox balance, inflammation, and apoptosis in lung disease.Transcription Factor NF-κB: An Update on Intervention Strategies.Emerging role of immunoproteasomes in pathophysiology.Nano-based rescue of dysfunctional autophagy in chronic obstructive lung diseases.Augmentation of S-Nitrosoglutathione Controls Cigarette Smoke-Induced Inflammatory-Oxidative Stress and Chronic Obstructive Pulmonary Disease-Emphysema Pathogenesis by Restoring Cystic Fibrosis Transmembrane Conductance Regulator Function.Acute cigarette smoke exposure impairs proteasome function in the lung.Cigarette smoke induces endoplasmic reticulum stress response and proteasomal dysfunction in human alveolar epithelial cells.MicroRNA-223 controls the expression of histone deacetylase 2: a novel axis in COPD.Endoplasmic Reticulum (ER) Stress Induces Sirtuin 1 (SIRT1) Expression via the PI3K-Akt-GSK3β Signaling Pathway and Promotes Hepatocellular Injury Cigarette smoke induced autophagy-impairment accelerates lung aging, COPD-emphysema exacerbations and pathogenesis.DJ-1 Modulates Nuclear Erythroid 2-Related Factor-2-Mediated Protection in Human Primary Alveolar Type II Cells in Smokers.

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Critical role of proteostasis-imbalance in pathogenesis of COPD and severe emphysema

http://www.wikidata.org/entity/Q35083187

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2011 nî lūn-bûn

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2011 թուականի Փետրուարին հրատարակուած գիտական յօդուած

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2011 թվականի փետրվարին հրատարակված գիտական հոդված

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2011年の論文

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2011年論文

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2011年論文

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2011年論文

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2011年論文

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2011年論文

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2011年论文

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name

Critical role of proteostasis-imbalance in pathogenesis of COPD and severe emphysema

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Critical role of proteostasis-imbalance in pathogenesis of COPD and severe emphysema

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type

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Critical role of proteostasis-imbalance in pathogenesis of COPD and severe emphysema

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Critical role of proteostasis-imbalance in pathogenesis of COPD and severe emphysema

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Critical role of proteostasis-imbalance in pathogenesis of COPD and severe emphysema

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Critical role of proteostasis-imbalance in pathogenesis of COPD and severe emphysema

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Journal of Molecular Medicine

P1476

Critical role of proteostasis-imbalance in pathogenesis of COPD and severe emphysema

@en

P2093

Manish Bodas

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Neeraj Vij

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Steven Mazur

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Taehong Min

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P2860

Global Strategy for the Diagnosis, Management, and Prevention of Chronic Obstructive Pulmonary Disease

Sequential quality-control checkpoints triage misfolded cystic fibrosis transmembrane conductance regulator

A complex of mammalian ufd1 and npl4 links the AAA-ATPase, p97, to ubiquitin and nuclear transport pathways

Keap1 represses nuclear activation of antioxidant responsive elements by Nrf2 through binding to the amino-terminal Neh2 domain

A novel ubiquitination factor, E4, is involved in multiubiquitin chain assembly.

CHIP is a U-box-dependent E3 ubiquitin ligase: identification of Hsc70 as a target for ubiquitylation

p47 is a cofactor for p97-mediated membrane fusion

ERAD: the long road to destruction

AAA ATPase p97/valosin-containing protein interacts with gp78, a ubiquitin ligase for endoplasmic reticulum-associated degradation

A selective inhibitor of eIF2alpha dephosphorylation protects cells from ER stress

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s00109-011-0732-8

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6

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49833352

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21318260

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chronic obstructive pulmonary disease

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3128462

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