Brain and bone damage in KARAP/DAP12 loss-of-function mice correlate with alterations in microglia and osteoclast lineages. - Wikidata - awgldk - TriplyDB

Brain and bone damage in KARAP/DAP12 loss-of-function mice correlate with alterations in microglia and osteoclast lineages.

Brain and bone damage in KARAP/DAP12 loss-of-function mice correlate with alterations in microglia and osteoclast lineages.

http://www.wikidata.org/entity/Q35083498

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Prenatal activation of microglia induces delayed impairment of glutamatergic synaptic function Signal adaptor DAP10 associates with MDL-1 and triggers osteoclastogenesis in cooperation with DAP12 Lymphocytes and the Dap12 adaptor are key regulators of osteoclast activation associated with gonadal failure.Pattern of DAP12 expression in leukocytes from both healthy and systemic lupus erythematosus patients.Gain in brain immunity in the oldest-old differentiates cognitively normal from demented individuals LC3, an autophagosome marker, is expressed on oligodendrocytes in Nasu-Hakola disease brains.CSF-1 receptor signaling in myeloid cells RNA-Seq analysis implicates dysregulation of the immune system in schizophrenia DAP12: an adapter protein with dual functionality.DAP12 overexpression induces osteopenia and impaired early hematopoiesis.Analysis of the host transcriptome from demyelinating spinal cord of murine coronavirus-infected mice.Th2-M2 immunity in lesions of muscular sarcoidosis and macrophagic myofasciitis.Developmental Controls are Re-Expressed during Induction of Neurogenesis in the Neocortex of Young Adult Mice.KARAP/DAP12/TYROBP: three names and a multiplicity of biological functions.The TREM2-DAP12 signaling pathway in Nasu-Hakola disease: a molecular genetics perspective.Role of ITAM-containing adapter proteins and their receptors in the immune system and bone.The TREM receptor family and signal integration.Essential role of DAP12 signaling in macrophage programming into a fusion-competent state.No evidence for shared etiology in two demyelinative disorders, MS and PLOSL Advances in osteoclast biology resulting from the study of osteopetrotic mutations.Infantile malignant, autosomal recessive osteopetrosis: the rich and the poor.Cross-regulation of signaling by ITAM-associated receptors.TYROBP in Alzheimer's disease.A Comprehensive Review of Immunoreceptor Regulation of Osteoclasts.Contributions of triggering-receptor-expressed-on-myeloid-cells-2 to neurological diseases.Macrophage colony-stimulating factor induces the proliferation and survival of macrophages via a pathway involving DAP12 and beta-catenin Gene expression profile of THP-1 monocytes following knockdown of DAP12, a causative gene for Nasu-Hakola disease.TREM2- and DAP12-dependent activation of PI3K requires DAP10 and is inhibited by SHIP1.Intrapulmonary, adenovirus-mediated overexpression of KARAP/DAP12 enhances fungal clearance during invasive aspergillosis Deficits in the miRNA-34a-regulated endogenous TREM2 phagocytosis sensor-receptor in Alzheimer's disease (AD); an update Developmental regulation of TREM2 and DAP12 expression in the murine CNS: implications for Nasu-Hakola disease.Mapping and kinetics of microglia/neuron cell-to-cell contacts in the 6-OHDA murine model of Parkinson's disease.Development and maintenance of the brain's immune toolkit: Microglia and non-parenchymal brain macrophages.Immunohistochemical characterization of CD33 expression on microglia in Nasu-Hakola disease brains.NG2 proteoglycan-expressing microglia as multipotent neural progenitors in normal and pathologic brains.Phosphorylated Syk expression is enhanced in Nasu-Hakola disease brains.Osteoclast-poor human osteopetrosis due to mutations in the gene encoding RANKL.Microglia in Alzheimer's Disease: Activated, Dysfunctional or Degenerative.Microglial TREM2/DAP12 Signaling: A Double-Edged Sword in Neural Diseases

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P2860

Brain and bone damage in KARAP/DAP12 loss-of-function mice correlate with alterations in microglia and osteoclast lineages.

http://www.wikidata.org/entity/Q35083498

description

2005 nî lūn-bûn

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2005 թուականի Յունուարին հրատարակուած գիտական յօդուած

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2005 թվականի հունվարին հրատարակված գիտական հոդված

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2005年の論文

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2005年論文

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2005年論文

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2005年論文

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2005年論文

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2005年論文

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2005年论文

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name

Brain and bone damage in KARAP ...... oglia and osteoclast lineages.

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Brain and bone damage in KARAP ...... oglia and osteoclast lineages.

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Brain and bone damage in KARAP ...... oglia and osteoclast lineages.

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Brain and bone damage in KARAP ...... oglia and osteoclast lineages.

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Brain and bone damage in KARAP ...... oglia and osteoclast lineages.

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Brain and bone damage in KARAP ...... oglia and osteoclast lineages.

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The American Journal of Pathology

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Brain and bone damage in KARAP ...... roglia and osteoclast lineages

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Adrienne Anginot

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Carine Vuaillat

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Christian Confavreux

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Christiane Dumontel

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Elena Tomasello

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Emmanuel Chereul

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Jean-Baptiste Langlois

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Laurence Vico

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P2860

Myeloid DAP12-associating lectin (MDL)-1 is a cell surface receptor involved in the activation of myeloid cells

Association of signal-regulatory proteins beta with KARAP/DAP-12

Immunoreceptor DAP12 bearing a tyrosine-based activation motif is involved in activating NK cells

Mutations in two genes encoding different subunits of a receptor signaling complex result in an identical disease phenotype

DAP12/TREM2 deficiency results in impaired osteoclast differentiation and osteoporotic features

Impaired differentiation of osteoclasts in TREM-2-deficient individuals

Flt3+ macrophage precursors commit sequentially to osteoclasts, dendritic cells and microglia.

Osteopetrosis and thalamic hypomyelinosis with synaptic degeneration in DAP12-deficient mice

Selective associations with signaling proteins determine stimulatory versus costimulatory activity of NKG2D

Cutting edge: signal-regulatory protein beta 1 is a DAP12-associated activating receptor expressed in myeloid cells

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1

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Marlène Mazzorana

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8099006

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