Regulation and Function of the RasGRP Family of Ras Activators in Blood Cells
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Human CalDAG-GEFI gene (RASGRP2) mutation affects platelet function and causes severe bleedingStructural analysis of autoinhibition in the Ras-specific exchange factor RasGRP1B lymphocyte antigen receptor signaling: initiation, amplification, and regulationThe Structure of Sec12 Implicates Potassium Ion Coordination in Sar1 ActivationRasGRPs are targets of the anti-cancer agent ingenol-3-angelateA genome-wide association study identifies GRK5 and RASGRP1 as type 2 diabetes loci in Chinese Hans.Platelet-Related Variants Identified by Exomechip Meta-analysis in 157,293 Individuals.Bryostatin analogue-induced apoptosis in mantle cell lymphoma cell linesSynthesis, biological, and biophysical studies of DAG-indololactones designed as selective activators of RasGRP.A cardiac-enriched microRNA, miR-378, blocks cardiac hypertrophy by targeting Ras signaling.Aberrant splicing of U12-type introns is the hallmark of ZRSR2 mutant myelodysplastic syndrome.Integrative analysis of transcriptional regulatory network and copy number variation in intrahepatic cholangiocarcinoma.CD117+ Dendritic and Mast Cells Are Dependent on RasGRP4 to Function as Accessory Cells for Optimal Natural Killer Cell-Mediated Responses to Lipopolysaccharide.Dysregulation of RasGRP1 in rheumatoid arthritis and modulation of RasGRP3 as a biomarker of TNFα inhibitors.Phospholipids: "greasing the wheels" of humoral immunityA negative-feedback loop regulating ERK1/2 activation and mediated by RasGPR2 phosphorylation.Activation of extracellular signal-regulated kinase but not of p38 mitogen-activated protein kinase pathways in lymphocytes requires allosteric activation of SOS.Structural Basis for the Failure of the C1 Domain of Ras Guanine Nucleotide Releasing Protein 2 (RasGRP2) to Bind Phorbol Ester with High Affinity.Rasgrp1 mutation increases naive T-cell CD44 expression and drives mTOR-dependent accumulation of Helios⁺ T cells and autoantibodies.Systemic Lupus Erythematosus: Old and New Susceptibility Genes versus Clinical Manifestations.Regulation of ras exchange factors and cellular localization of ras activation by lipid messengers in T cells.RasGRP Ras guanine nucleotide exchange factors in cancer.Does B cell receptor signaling in chronic lymphocytic leukaemia cells differ from that in other B cell types?RasGRP3 Mediates MAPK Pathway Activation in GNAQ Mutant Uveal Melanoma.K-Ras4B/calmodulin/PI3Kα: A promising new adenocarcinoma-specific drug target?Diacylglycerol metabolism attenuates T-cell receptor signaling and alters thymocyte differentiation.Ras guanyl nucleotide releasing protein 2 affects cell viability and cell-matrix adhesion in ECV304 endothelial cells.GPCR activation of Ras and PI3Kc in neutrophils depends on PLCb2/b3 and the RasGEF RasGRP4.RasGRP1 and RasGRP3 Are Required for Efficient Generation of Early Thymic Progenitors.Graded inhibition of oncogenic Ras-signaling by multivalent Ras-binding domains.CD275-Independent IL-17-Producing T Follicular Helper-like Cells in Lymphopenic Autoimmune-Prone Mice.Distinct oncogenic Ras signals characterized by profound differences in flux through the RasGDP/RasGTP cycleA Histidine pH sensor regulates activation of the Ras-specific guanine nucleotide exchange factor RasGRP1.Superoxide inhibits guanine nucleotide exchange factor (GEF) action on Ras, but not on Rho, through desensitization of Ras to GEF.Sos1 regulates sustained TCR-mediated Erk activation.Importance of the REM (Ras exchange) domain for membrane interactions by RasGRP3.Effect of corticision on orthodontic tooth movement in a rat model as assessed by RNA sequencing.Exploring the influence of indololactone structure on selectivity for binding to the C1 domains of PKCα, PKCε, and RasGRP.Calcium-induced structural rearrangements release autoinhibition in the Rap-GEF, CalDAG-GEFI.Amplification of B cell receptor-Erk signaling by Rasgrf-1 overexpression in chronic lymphocytic leukemia.
P2860
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P2860
Regulation and Function of the RasGRP Family of Ras Activators in Blood Cells
description
2011 nî lūn-bûn
@nan
2011 թուականի Մարտին հրատարակուած գիտական յօդուած
@hyw
2011 թվականի մարտին հրատարակված գիտական հոդված
@hy
2011年の論文
@ja
2011年論文
@yue
2011年論文
@zh-hant
2011年論文
@zh-hk
2011年論文
@zh-mo
2011年論文
@zh-tw
2011年论文
@wuu
name
Regulation and Function of the RasGRP Family of Ras Activators in Blood Cells
@ast
Regulation and Function of the RasGRP Family of Ras Activators in Blood Cells
@en
type
label
Regulation and Function of the RasGRP Family of Ras Activators in Blood Cells
@ast
Regulation and Function of the RasGRP Family of Ras Activators in Blood Cells
@en
prefLabel
Regulation and Function of the RasGRP Family of Ras Activators in Blood Cells
@ast
Regulation and Function of the RasGRP Family of Ras Activators in Blood Cells
@en
P2860
P356
P1433
P1476
Regulation and Function of the RasGRP Family of Ras Activators in Blood Cells
@en
P2093
James C Stone
P2860
P304
P356
10.1177/1947601911408082
P577
2011-03-01T00:00:00Z