HDAC4-regulated STAT1 activation mediates platinum resistance in ovarian cancer. - Wikidata - awgldk - TriplyDB

HDAC4-regulated STAT1 activation mediates platinum resistance in ovarian cancer.

HDAC4-regulated STAT1 activation mediates platinum resistance in ovarian cancer.

http://www.wikidata.org/entity/Q35087685

about

Tasquinimod Is an Allosteric Modulator of HDAC4 survival signaling within the compromised cancer microenvironment Novel drug targets for personalized precision medicine in relapsed/refractory diffuse large B-cell lymphoma: a comprehensive review Preventing Damage Limitation: Targeting DNA-PKcs and DNA Double-Strand Break Repair Pathways for Ovarian Cancer Therapy A genome-scale screen reveals context-dependent ovarian cancer sensitivity to miRNA overexpression Proteomic Analysis of HDAC3 Selective Inhibitor in the Regulation of Inflammatory Response of Primary Microglia A distance-based test of association between paired heterogeneous genomic data.A putative biomarker signature for clinically effective AKT inhibition: correlation of in vitro, in vivo and clinical data identifies the importance of modulation of the mTORC1 pathway.Modeling platinum sensitive and resistant high-grade serous ovarian cancer: development and applications of experimental systems.BRCA1/2 mutation analysis in 41 ovarian cell lines reveals only one functionally deleterious BRCA1 mutation.Chromatin proteins and modifications as drug targets.HDAC4: mechanism of regulation and biological functions Histone deacetylases and cancer.Epigenetic therapies as a promising strategy for overcoming chemoresistance in epithelial ovarian cancer Down-regulation of Ras-related protein Rab 5C-dependent endocytosis and glycolysis in cisplatin-resistant ovarian cancer cell lines.Increased sensitivity to chemotherapy induced by CpG-ODN treatment is mediated by microRNA modulation.miR-29b, miR-205 and miR-221 enhance chemosensitivity to gemcitabine in HuH28 human cholangiocarcinoma cells.Panobinostat reduces hypoxia-induced cisplatin resistance of non-small cell lung carcinoma cells via HIF-1α destabilization Global Oct4 target gene analysis reveals novel downstream PTEN and TNC genes required for drug-resistance and metastasis in lung cancer.HDAC4, a prognostic and chromosomal instability marker, refines the predictive value of MGMT promoter methylation.Inhibition of histone deacetylase 4 increases cytotoxicity of docetaxel in gastric cancer cells.miR-125a-5p is a prognostic biomarker that targets HDAC4 to suppress breast tumorigenesis.DNA-PK mediates AKT activation and apoptosis inhibition in clinically acquired platinum resistance.Functional role of miR-10b in tamoxifen resistance of ER-positive breast cancer cells through down-regulation of HDAC4.MicroRNA-30a sensitizes tumor cells to cis-platinum via suppressing beclin 1-mediated autophagy Rethinking ovarian cancer: recommendations for improving outcomes.The role of interleukin-8 (IL-8) and IL-8 receptors in platinum response in high grade serous ovarian carcinoma The RNA-binding protein LARP1 is a post-transcriptional regulator of survival and tumorigenesis in ovarian cancer.Phospho-ΔNp63α/microRNA feedback regulation in squamous carcinoma cells upon cisplatin exposure Histone deacetylases and mechanisms of regulation of gene expression The role of HDAC2 in chromatin remodelling and response to chemotherapy in ovarian cancer.β-Arrestins promote podocyte injury by inhibition of autophagy in diabetic nephropathy.Phosphorylation of signal transducer and activator of transcription 1 reduces bortezomib-mediated apoptosis in cancer cells.Natural compound-derived epigenetic regulators targeting epigenetic readers, writers and erasers.Downregulation of Foxo3 and TRIM31 by miR-551b in side population promotes cell proliferation, invasion, and drug resistance of ovarian cancer.Oxidative metabolism drives inflammation-induced platinum resistance in human ovarian cancer.Inhibition of HDAC1 and DNMT1 modulate RGS10 expression and decrease ovarian cancer chemoresistance.The gep proto-oncogene Gα12 mediates LPA-stimulated activation of CREB in ovarian cancer cells.STAT1 and STAT3 in tumorigenesis: A matter of balance.Targeting the histone orthography of cancer: drugs for writers, erasers and readers.Common biological phenotypes characterize the acquisition of platinum-resistance in epithelial ovarian cancer cells.

P2860

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P2860

HDAC4-regulated STAT1 activation mediates platinum resistance in ovarian cancer.

http://www.wikidata.org/entity/Q35087685

description

2011 nî lūn-bûn

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2011 թուականի Մայիսին հրատարակուած գիտական յօդուած

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2011 թվականի մայիսին հրատարակված գիտական հոդված

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2011年の論文

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2011年論文

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2011年論文

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2011年論文

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2011年論文

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2011年論文

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2011年论文

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name

HDAC4-regulated STAT1 activation mediates platinum resistance in ovarian cancer.

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HDAC4-regulated STAT1 activation mediates platinum resistance in ovarian cancer.

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type

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HDAC4-regulated STAT1 activation mediates platinum resistance in ovarian cancer.

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HDAC4-regulated STAT1 activation mediates platinum resistance in ovarian cancer.

@en

prefLabel

HDAC4-regulated STAT1 activation mediates platinum resistance in ovarian cancer.

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HDAC4-regulated STAT1 activation mediates platinum resistance in ovarian cancer.

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0008-5472.CAN-10-4111

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Cancer Research

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HDAC4-regulated STAT1 activation mediates platinum resistance in ovarian cancer

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Albandri Alfraidi

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Bryan T Hennessy

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Charlie Gourley

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Christoph Datler

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Euan A Stronach

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Gordon B Mills

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James B Studd

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Nona Rama

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Robert Brown

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Roberto Dina

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P2860

Stress-dependent regulation of FOXO transcription factors by the SIRT1 deacetylase

Crosstalk between sumoylation and acetylation regulates p53-dependent chromatin transcription and DNA binding

Rapid colorimetric assay for cellular growth and survival: Application to proliferation and cytotoxicity assays

Systematic variation in gene expression patterns in human cancer cell lines

Arginine/lysine-rich nuclear localization signals mediate interactions between dimeric STATs and importin alpha 5

Molecular profiling of platinum resistant ovarian cancer.

Somatic mutations in BRCA1 and BRCA2 could expand the number of patients that benefit from poly (ADP ribose) polymerase inhibitors in ovarian cancer.

Regulated nuclear import of the STAT1 transcription factor by direct binding of importin-alpha

Genomic analysis of genetic heterogeneity and evolution in high-grade serous ovarian carcinoma.

Mechanisms of resistance to cisplatin.

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4412-4422

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10.1158/0008-5472.CAN-10-4111

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13

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21571862

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