Osteopontin deficiency protects against obesity-induced hepatic steatosis and attenuates glucose production in mice. - Wikidata - awgldk - TriplyDB

Osteopontin deficiency protects against obesity-induced hepatic steatosis and attenuates glucose production in mice.

Osteopontin deficiency protects against obesity-induced hepatic steatosis and attenuates glucose production in mice.

http://www.wikidata.org/entity/Q35091574

about

Role of Osteopontin in Liver Diseases Osteopontin deletion prevents the development of obesity and hepatic steatosis via impaired adipose tissue matrix remodeling and reduced inflammation and fibrosis in adipose tissue and liver in mice Revisiting the adipocyte: a model for integration of cytokine signaling in the regulation of energy metabolism The osteopontin level in liver, adipose tissue and serum is correlated with fibrosis in patients with alcoholic liver disease Osteopontin: A novel regulator at the cross roads of inflammation, obesity and diabetes.CD44 plays a critical role in regulating diet-induced adipose inflammation, hepatic steatosis, and insulin resistance Composition of dietary fat source shapes gut microbiota architecture and alters host inflammatory mediators in mouse adipose tissue.Differential responses of hepatic endoplasmic reticulum stress and inflammation in diet-induced obese rats with high-fat diet rich in lard oil or soybean oil Cytochrome P450 1B1: An unexpected modulator of liver fatty acid homeostasis Anti-CD44 antibody treatment lowers hyperglycemia and improves insulin resistance, adipose inflammation, and hepatic steatosis in diet-induced obese mice.Wogonin suppresses osteopontin expression in adipocytes by activating PPARα Macrophage-mediated inflammation in metabolic disease CTX (crosslaps) rather than osteopontin is associated with disturbed glucose metabolism in gestational diabetes.Retinoic acid-related orphan receptors α and γ: key regulators of lipid/glucose metabolism, inflammation, and insulin sensitivity Osteopontin is a proximal effector of leptin-mediated non-alcoholic steatohepatitis (NASH) fibrosis.Factor XIII-A transglutaminase deficient mice show signs of metabolically healthy obesity on high fat diet.An accelerated mouse model for atherosclerosis and adipose tissue inflammation.Osteopontin: Relation between Adipose Tissue and Bone Homeostasis An osteopontin-integrin interaction plays a critical role in directing adipogenesis and osteogenesis by mesenchymal stem cells.Review article: non-alcoholic fatty liver disease and osteoporosis--clinical and molecular crosstalk.Osteopontin: Versatile modulator of liver diseases.High Glucose Accelerates Cell Proliferation and Increases the Secretion and mRNA Expression of Osteopontin in Human Pancreatic Duct Epithelial Cells.Dietary fat proportionately enhances oxidative stress and glucose intolerance followed by impaired expression of the genes associated with mitochondrial biogenesis.Osteopontin affects macrophage polarization promoting endocytic but not inflammatory properties.Osteopontin induces growth of metastatic tumors in a preclinical model of non-small lung cancer.Regulation of the pro-inflammatory cytokine osteopontin by GIP in adipocytes--a role for the transcription factor NFAT and phosphodiesterase 3B.Tiron ameliorates high glucose-induced cardiac myocyte apoptosis by PKCδ-dependent inhibition of osteopontin.Osteopontin regulates the cross-talk between phosphatidylcholine and cholesterol metabolism in mouse liver.Effect of vanadium on calcium homeostasis, osteopontin mRNA expression, and bone microarchitecture in diabetic rats.A preliminary in vivo study of the effects of OPN on rat liver regeneration induced by partial hepatectomy.Immunological blockade of adipocyte inflammation caused by increased matrix metalloproteinase-cleaved osteopontin in obesity.Expression profiles uncover the correlation of OPN signaling pathways with rat liver regeneration at cellular level.Circulating osteopontin and its association with liver fat content in non-obese women with polycystic ovary syndrome: a case control study.Novel insights into the relationship between nonalcoholic fatty liver disease and osteoporosis Comparative effects of gastric bypass and sleeve gastrectomy on plasma osteopontin concentrations in humans

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Osteopontin deficiency protects against obesity-induced hepatic steatosis and attenuates glucose production in mice.

http://www.wikidata.org/entity/Q35091574

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Role of osteopontin in adhesion, migration, cell survival and bone remodeling

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MCP-1 contributes to macrophage infiltration into adipose tissue, insulin resistance, and hepatic steatosis in obesity

Obesity as a medical problem

Chemokines and leukocyte traffic

Local and systemic insulin resistance resulting from hepatic activation of IKK-beta and NF-kappaB

TLR4 enhances TGF-beta signaling and hepatic fibrosis

Depletion of liver Kupffer cells prevents the development of diet-induced hepatic steatosis and insulin resistance.

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