Mutational analysis of a critical signaling domain of the human interleukin 4 receptor.
about
The c-Mpl ligand (thrombopoietin) stimulates tyrosine phosphorylation of Jak2, Shc, and c-MplDifferential associations between the cytoplasmic regions of the interleukin-12 receptor subunits beta1 and beta2 and JAK kinasesThe interleukin (IL)-2 family cytokines: survival and proliferation signaling pathways in T lymphocytes.Interleukin-4-specific signal transduction events are driven by homotypic interactions of the interleukin-4 receptor alpha subunit.Regulation of inflammation by interleukin-4: a review of "alternatives"Direct evidence of a heterotrimeric complex of human interleukin-4 with its receptors.Cloning of murine Stat6 and human Stat6, Stat proteins that are tyrosine phosphorylated in responses to IL-4 and IL-3 but are not required for mitogenesis.The murine DUB-1 gene is specifically induced by the betac subunit of interleukin-3 receptor.A potent human interleukin-4 antagonist stimulates the proliferation of murine cells expressing the human interleukin-4 binding chain.Interleukin 4-inducible phosphorylation of HMG-I(Y) is inhibited by rapamycin.Intracellular tyrosine residues of the human growth hormone receptor are not required for the signaling of proliferation or Jak-STAT activation.Design of conditionally active STATs: insights into STAT activation and gene regulatory function.Distinct signal transduction through the tyrosine-containing domains of the granulocyte colony-stimulating factor receptor.Activation of STAT5 by IL-4 relies on Janus kinase function but not on receptor tyrosine phosphorylation, and can contribute to both cell proliferation and gene regulation.The interleukin-4 receptor activates STAT5 by a mechanism that relies upon common gamma-chain.Homodimerization of interleukin-4 receptor alpha chain can induce intracellular signaling.Growth signal transduction by the human interleukin-2 receptor requires cytoplasmic tyrosines of the beta chain and non-tyrosine residues of the gamma c chain.Pressuromodulation at the cell membrane as the basis for small molecule hormone and peptide regulation of cellular and nuclear functionInterleukin-13 signal transduction in lymphohemopoietic cells. Similarities and differences in signal transduction with interleukin-4 and insulin.Activation of JAK3, but not JAK1, is critical to interleukin-4 (IL4) stimulated proliferation and requires a membrane-proximal region of IL4 receptor alpha.
P2860
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P2860
Mutational analysis of a critical signaling domain of the human interleukin 4 receptor.
description
1994 nî lūn-bûn
@nan
1994 թուականի Մարտին հրատարակուած գիտական յօդուած
@hyw
1994 թվականի մարտին հրատարակված գիտական հոդված
@hy
1994年の論文
@ja
1994年論文
@yue
1994年論文
@zh-hant
1994年論文
@zh-hk
1994年論文
@zh-mo
1994年論文
@zh-tw
1994年论文
@wuu
name
Mutational analysis of a critical signaling domain of the human interleukin 4 receptor.
@ast
Mutational analysis of a critical signaling domain of the human interleukin 4 receptor.
@en
type
label
Mutational analysis of a critical signaling domain of the human interleukin 4 receptor.
@ast
Mutational analysis of a critical signaling domain of the human interleukin 4 receptor.
@en
prefLabel
Mutational analysis of a critical signaling domain of the human interleukin 4 receptor.
@ast
Mutational analysis of a critical signaling domain of the human interleukin 4 receptor.
@en
P2860
P356
P1476
Mutational analysis of a critical signaling domain of the human interleukin 4 receptor.
@en
P2093
P2860
P304
P356
10.1073/PNAS.91.6.2140
P407
P577
1994-03-01T00:00:00Z