Partially redundant enhancers cooperatively maintain Mammalian pomc expression above a critical functional threshold
about
Regulatory activities of transposable elements: from conflicts to benefits.Islet 1 specifies the identity of hypothalamic melanocortin neurons and is critical for normal food intake and adiposity in adulthoodEnhancer additivity and non-additivity are determined by enhancer strength in the Drosophila embryo.Krüppel Expression Levels Are Maintained through Compensatory Evolution of Shadow Enhancers.Hypothalamic POMC Deficiency Improves Glucose Tolerance Despite Insulin Resistance by Increasing Glycosuria.Long Terminal Repeats: From Parasitic Elements to Building Blocks of the Transcriptional Regulatory RepertoireReprogramming the body weight set point by a reciprocal interaction of hypothalamic leptin sensitivity and Pomc gene expression reverts extreme obesityRegulatory Domains and Their Mechanisms.Modeling disease risk through analysis of physical interactions between genetic variants within chromatin regulatory circuitry.Krox20 hindbrain regulation incorporates multiple modes of cooperation between cis-acting elements.Hypothalamic-specific proopiomelanocortin deficiency reduces alcohol drinking in male and female mice.Shadow Enhancers Are Pervasive Features of Developmental Regulatory Networks.Human evolution: the non-coding revolution.Global reorganisation of cis-regulatory units upon lineage commitment of human embryonic stem cells.Enhancers and super-enhancers have an equivalent regulatory role in embryonic stem cells through regulation of single or multiple genes.Correction: partially redundant enhancers cooperatively maintain Mammalian pomc expression above a critical functional threshold.V1b Receptor Antagonist SSR149415 and Naltrexone Synergistically Decrease Excessive Alcohol Drinking in Male and Female Mice.Multiplex Enhancer Interference Reveals Collaborative Control of Gene Regulation by Estrogen Receptor α-Bound Enhancers.Chromatin modifications in metabolic disease: Potential mediators of long-term disease risk.17α-estradiol acts through hypothalamic pro-opiomelanocortin expressing neurons to reduce feeding behavior.Hypothalamic ER-associated degradation regulates POMC maturation, feeding, and age-associated obesity.Enhancer redundancy provides phenotypic robustness in mammalian development.Involvement of activated brain stress responsive systems in excessive and "relapse" alcohol drinking in rodent models: implications for therapeutics.Assessing sufficiency and necessity of enhancer activities for gene expression and the mechanisms of transcription activation.Cooperation, cis-interactions, versatility and evolutionary plasticity of multiple cis-acting elements underlie krox20 hindbrain regulation
P2860
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P2860
Partially redundant enhancers cooperatively maintain Mammalian pomc expression above a critical functional threshold
description
2015 nî lūn-bûn
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2015 թուականի Փետրուարին հրատարակուած գիտական յօդուած
@hyw
2015 թվականի փետրվարին հրատարակված գիտական հոդված
@hy
2015年の論文
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2015年論文
@yue
2015年論文
@zh-hant
2015年論文
@zh-hk
2015年論文
@zh-mo
2015年論文
@zh-tw
2015年论文
@wuu
name
Partially redundant enhancers ...... critical functional threshold
@ast
Partially redundant enhancers ...... critical functional threshold
@en
type
label
Partially redundant enhancers ...... critical functional threshold
@ast
Partially redundant enhancers ...... critical functional threshold
@en
prefLabel
Partially redundant enhancers ...... critical functional threshold
@ast
Partially redundant enhancers ...... critical functional threshold
@en
P2093
P2860
P50
P1433
P1476
Partially redundant enhancers ...... critical functional threshold
@en
P2093
Harini Sampath
Kana Meece
Malcolm J Low
Marcelo Rubinstein
Miho Yamashita
Rodrigo López-Leal
Sharon L Wardlaw
Sofia Nasif
Veronica Otero-Corchon
P2860
P304
P356
10.1371/JOURNAL.PGEN.1004935
P577
2015-02-11T00:00:00Z