Clioquinol promotes the degradation of metal-dependent amyloid-β (Aβ) oligomers to restore endocytosis and ameliorate Aβ toxicity.
about
Current Research Therapeutic Strategies for Alzheimer's Disease TreatmentUsing C. elegans to discover therapeutic compounds for ageing-associated neurodegenerative diseasesSynthetic fluorescent probes for studying copper in biological systemsDrug repositioning approaches for the discovery of new therapeutics for Alzheimer's diseaseTruncated Amyloid-β(11-40/42) from Alzheimer Disease Binds Cu2+ with a Femtomolar Affinity and Influences Fiber Assembly.The hairpin conformation of the amyloid β peptide is an important structural motif along the aggregation pathway.Ubiquitin-dependent proteolysis in yeast cells expressing neurotoxic proteins.Regulation of extracellular Zn(2+) homeostasis in the hippocampus as a therapeutic target for Alzheimer's disease.Is interaction of amyloid β-peptides with metals involved in cognitive activity?Toward stem cell-based phenotypic screens for neurodegenerative diseases.Yeast Model of Amyloid-β and Tau Aggregation in Alzheimer's Disease.Ultraviolet light triggers the conversion of Cu2+-bound Aβ42 aggregates into cytotoxic species in a copper chelation-independent manner.Role of frameshift ubiquitin B protein in Alzheimer's disease.HIV-1 matrix protein p17 misfolding forms toxic amyloidogenic assemblies that induce neurocognitive disorders.Amyloid-β peptide-induced cytotoxicity and mitochondrial dysfunction in yeast.Cyclic cis-Locked Phospho-Dipeptides Reduce Entry of AβPP into Amyloidogenic Processing Pathway.Pretreatment of chemically-synthesized Aβ42 affects its biological activity in yeast.Rationally designed peptidomimetic modulators of aβ toxicity in Alzheimer's disease.Inhibition of Aβ42 oligomerization in yeast by a PICALM ortholog and certain FDA approved drugs.Biometal Dyshomeostasis and Toxic Metal Accumulations in the Development of Alzheimer's Disease.Effect of metal chelators on the aggregation of beta-amyloid peptides in the presence of copper and iron.Cardiac Light Chain Amyloidosis: The Role of Metal Ions in Oxidative Stress and Mitochondrial Damage.A randomized, exploratory molecular imaging study targeting amyloid β with a novel 8-OH quinoline in Alzheimer's disease: The PBT2-204 IMAGINE study.Dihydropyrimidine-Thiones and Clioquinol Synergize To Target β-Amyloid Cellular Pathologies through a Metal-Dependent Mechanism.Investigation of the Subcellular Neurotoxicity of Amyloid-β Using a Device Integrating Microfluidic Perfusion and Chemotactic Guidance.Cu²⁺ accentuates distinct misfolding of Aβ₁₋₄₀ and Aβ₁₋₄₂ peptides, and potentiates membrane disruption.How Surrogate and Chemical Genetics in Model Organisms Can Suggest Therapies for Human Genetic Diseases.
P2860
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P2860
Clioquinol promotes the degradation of metal-dependent amyloid-β (Aβ) oligomers to restore endocytosis and ameliorate Aβ toxicity.
description
2014 nî lūn-bûn
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2014 թուականի Մարտին հրատարակուած գիտական յօդուած
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2014 թվականի մարտին հրատարակված գիտական հոդված
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2014年の論文
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2014年論文
@yue
2014年論文
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2014年論文
@zh-hk
2014年論文
@zh-mo
2014年論文
@zh-tw
2014年论文
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name
Clioquinol promotes the degrad ...... is and ameliorate Aβ toxicity.
@ast
Clioquinol promotes the degrad ...... is and ameliorate Aβ toxicity.
@en
type
label
Clioquinol promotes the degrad ...... is and ameliorate Aβ toxicity.
@ast
Clioquinol promotes the degrad ...... is and ameliorate Aβ toxicity.
@en
prefLabel
Clioquinol promotes the degrad ...... is and ameliorate Aβ toxicity.
@ast
Clioquinol promotes the degrad ...... is and ameliorate Aβ toxicity.
@en
P2093
P2860
P356
P1476
Clioquinol promotes the degrad ...... is and ameliorate Aβ toxicity.
@en
P2093
Daniel F Tardiff
Guy A Caldwell
Kent E S Matlack
Kim A Caldwell
Priyanka Narayan
Shusei Hamamichi
P2860
P304
P356
10.1073/PNAS.1402228111
P407
P577
2014-03-03T00:00:00Z