Contribution of the C-8 substituent of DU-6859a, a new potent fluoroquinolone, to its activity against DNA gyrase mutants of Pseudomonas aeruginosa.
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DNA gyrase, topoisomerase IV, and the 4-quinolonesFluoroquinolone action against clinical isolates of Mycobacterium tuberculosis: effects of a C-8 methoxyl group on survival in liquid media and in human macrophagesFluoroquinolone action against mycobacteria: effects of C-8 substituents on growth, survival, and resistanceCloning, expression, and enzymatic characterization of Pseudomonas aeruginosa topoisomerase IVDNA topoisomerase targets of the fluoroquinolones: a strategy for avoiding bacterial resistance.Recent progress in novel macrolides, quinolones, and 2-pyridones to overcome bacterial resistance.Type II topoisomerase mutations in fluoroquinolone-resistant clinical strains of Pseudomonas aeruginosa isolated in 1998 and 1999: role of target enzyme in mechanism of fluoroquinolone resistance.Combinatorially-generated library of 6-fluoroquinolone analogs as potential novel antitubercular agents: a chemometric and molecular modeling assessment.High-level fluoroquinolone resistance in Pseudomonas aeruginosa due to interplay of the MexAB-OprM efflux pump and the DNA gyrase mutation.Specific patterns of gyrA mutations determine the resistance difference to ciprofloxacin and levofloxacin in Klebsiella pneumoniae and Escherichia coliImproved antimicrobial activity of DU-6859a, a new fluoroquinolone, against quinolone-resistant Klebsiella pneumoniae and Enterobacter cloacae isolates with alterations in GyrA and ParC proteinsHelicobacter pylori eradication by sitafloxacin-lansoprazole combination and sitafloxacin pharmacokinetics in Mongolian gerbils and its in vitro activity and resistance development.Update on the treatment of Pseudomonas aeruginosa pneumonia.New antimicrobial strategies in cystic fibrosis.Gatifloxacin activity against quinolone-resistant gyrase: allele-specific enhancement of bacteriostatic and bactericidal activities by the C-8-methoxy group.Mutation in the DNA gyrase A Gene of Escherichia coli that expands the quinolone resistance-determining regionEnhancement of fluoroquinolone activity by C-8 halogen and methoxy moieties: action against a gyrase resistance mutant of Mycobacterium smegmatis and a gyrase-topoisomerase IV double mutant of Staphylococcus aureus.Killing of Staphylococcus aureus by C-8-methoxy fluoroquinolones.Selection of Streptococcus pneumoniae mutants having reduced susceptibility to moxifloxacin and levofloxacin.Quinolone-resistant mutants of escherichia coli DNA topoisomerase IV parC geneComparison of recalcitrance to ciprofloxacin and levofloxacin exhibited by Pseudomonas aeruginosa bofilms displaying rapid-transport characteristics.Activities of mutant prevention concentration-targeted moxifloxacin and levofloxacin against Streptococcus pneumoniae in an in vitro pharmacodynamic model.Multiplex PCR amplimer conformation analysis for rapid detection of gyrA mutations in fluoroquinolone-resistant Mycobacterium tuberculosis clinical isolates.Relationships among ciprofloxacin, gatifloxacin, levofloxacin, and norfloxacin MICs for fluoroquinolone-resistant Escherichia coli clinical isolatesPropensity of fluoroquinolones with different moieties at position 8 to cause resistance development in clinical isolates of Streptococcus pneumoniae.Contribution of the C-8-methoxy group of gatifloxacin to inhibition of type II topoisomerases of Staphylococcus aureus.Cluster-based molecular docking study for in silico identification of novel 6-fluoroquinolones as potential inhibitors against Mycobacterium tuberculosis.Structure-activity relationship of fluoroquinolone in Escherichia coli.
P2860
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P2860
Contribution of the C-8 substituent of DU-6859a, a new potent fluoroquinolone, to its activity against DNA gyrase mutants of Pseudomonas aeruginosa.
description
1995 nî lūn-bûn
@nan
1995 թուականի Յուլիսին հրատարակուած գիտական յօդուած
@hyw
1995 թվականի հուլիսին հրատարակված գիտական հոդված
@hy
1995年の論文
@ja
1995年論文
@yue
1995年論文
@zh-hant
1995年論文
@zh-hk
1995年論文
@zh-mo
1995年論文
@zh-tw
1995年论文
@wuu
name
Contribution of the C-8 substi ...... nts of Pseudomonas aeruginosa.
@ast
Contribution of the C-8 substi ...... nts of Pseudomonas aeruginosa.
@en
type
label
Contribution of the C-8 substi ...... nts of Pseudomonas aeruginosa.
@ast
Contribution of the C-8 substi ...... nts of Pseudomonas aeruginosa.
@en
prefLabel
Contribution of the C-8 substi ...... nts of Pseudomonas aeruginosa.
@ast
Contribution of the C-8 substi ...... nts of Pseudomonas aeruginosa.
@en
P2093
P2860
P356
P1476
Contribution of the C-8 substi ...... nts of Pseudomonas aeruginosa.
@en
P2093
P2860
P304
P356
10.1128/AAC.39.7.1467
P407
P577
1995-07-01T00:00:00Z