Direct association of ligand-binding and pore domains in homo- and heterotetrameric inositol 1,4,5-trisphosphate receptors.
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Using concatenated subunits to investigate the functional consequences of heterotetrameric inositol 1,4,5-trisphosphate receptorsInteraction of FKBP12.6 with the cardiac ryanodine receptor C-terminal domainTyr-167/Trp-168 in type 1/3 inositol 1,4,5-trisphosphate receptor mediates functional coupling between ligand binding and channel openingFlexible architecture of IP3R1 by Cryo-EMTargeted expression of the inositol 1,4,5-triphosphate receptor (IP3R) ligand-binding domain releases Ca2+ via endogenous IP3R channels.Binding of inositol 1,4,5-trisphosphate (IP3) and adenophostin A to the N-terminal region of the IP3 receptor: thermodynamic analysis using fluorescence polarization with a novel IP3 receptor ligand.Inositol trisphosphate receptor Ca2+ release channels.Role of caspase-3 cleaved IP3 R1 on Ca(2+) homeostasis and developmental competence of mouse oocytes and eggsCaspase-3-truncated type 1 inositol 1,4,5-trisphosphate receptor enhances intracellular Ca2+ leak and disturbs Ca2+ signalling.Toward a high-resolution structure of IP₃R channel.Functional characterization of the type 1 inositol 1,4,5-trisphosphate receptor coupling domain SII(+/-) splice variants and the Opisthotonos mutant form.Functional properties of the Drosophila melanogaster inositol 1,4,5-trisphosphate receptor mutantsCytochrome c binds to inositol (1,4,5) trisphosphate receptors, amplifying calcium-dependent apoptosis.Aberrant calcium signaling by transglutaminase-mediated posttranslational modification of inositol 1,4,5-trisphosphate receptorsReceptor-interacting protein 140 attenuates endoplasmic reticulum stress in neurons and protects against cell deathModels of IP3 and Ca2+ oscillations: frequency encoding and identification of underlying feedbacksMolecular characterization of the inositol 1,4,5-trisphosphate receptor pore-forming segment.Domain organization of the type 1 inositol 1,4,5-trisphosphate receptor as revealed by single-particle analysis.Chaperone-mediated coupling of endoplasmic reticulum and mitochondrial Ca2+ channels.Single channel function of inositol 1,4,5-trisphosphate receptor type-1 and -2 isoform domain-swap chimeras.Identification of functionally critical residues in the channel domain of inositol trisphosphate receptorsAgonist-induced Ca2+ entry determined by inositol 1,4,5-trisphosphate recognition.Unique Regulatory Properties of Heterotetrameric Inositol 1,4,5-Trisphosphate Receptors Revealed by Studying Concatenated Receptor Constructs.Gating machinery of InsP3R channels revealed by electron cryomicroscopyFragmented inositol 1,4,5-trisphosphate receptors retain tetrameric architecture and form functional Ca2+ release channels.Defining the stoichiometry of inositol 1,4,5-trisphosphate binding required to initiate Ca2+ release.Characterization of a flatworm inositol (1,4,5) trisphosphate receptor (IP₃R) reveals a role in reproductive physiologyGranulosa cells express three inositol 1,4,5-trisphosphate receptor isoforms: cytoplasmic and nuclear Ca2+ mobilization.Functional inositol 1,4,5-trisphosphate receptors assembled from concatenated homo- and heteromeric subunits.Regulation of inositol 1,4,5-trisphosphate receptor type 1 function during oocyte maturation by MPM-2 phosphorylation.Targeting and clustering of IP3 receptors: key determinants of spatially organized Ca2+ signals.Linking structure to function: Recent lessons from inositol 1,4,5-trisphosphate receptor mutagenesis.IP(3) receptors: toward understanding their activation.Ryanodine receptor calcium release channels: lessons from structure-function studies.Structural organization of signalling to and from IP3 receptors.Rat inositol 1,4,5-trisphosphate receptor isoform 2 interacts with itself in its C-terminal portion and upstream of the first transmembrane domain.Regulatory Mechanisms of Endoplasmic Reticulum Resident IP3 Receptors.Structure of IP3R channel: high-resolution insights from cryo-EM.Calcium at the Center of Cell Signaling: Interplay between Endoplasmic Reticulum, Mitochondria, and Lysosomes.Endogenously bound calmodulin is essential for the function of the inositol 1,4,5-trisphosphate receptor.
P2860
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P2860
Direct association of ligand-binding and pore domains in homo- and heterotetrameric inositol 1,4,5-trisphosphate receptors.
description
2000 nî lūn-bûn
@nan
2000 թուականի Հոկտեմբերին հրատարակուած գիտական յօդուած
@hyw
2000 թվականի հոտեմբերին հրատարակված գիտական հոդված
@hy
2000年の論文
@ja
2000年論文
@yue
2000年論文
@zh-hant
2000年論文
@zh-hk
2000年論文
@zh-mo
2000年論文
@zh-tw
2000年论文
@wuu
name
Direct association of ligand-b ...... 1,4,5-trisphosphate receptors.
@ast
Direct association of ligand-b ...... 1,4,5-trisphosphate receptors.
@en
type
label
Direct association of ligand-b ...... 1,4,5-trisphosphate receptors.
@ast
Direct association of ligand-b ...... 1,4,5-trisphosphate receptors.
@en
prefLabel
Direct association of ligand-b ...... 1,4,5-trisphosphate receptors.
@ast
Direct association of ligand-b ...... 1,4,5-trisphosphate receptors.
@en
P2860
P356
P1433
P1476
Direct association of ligand-b ...... 1,4,5-trisphosphate receptors.
@en
P2093
D Boehning
S K Joseph
P2860
P304
P356
10.1093/EMBOJ/19.20.5450
P407
P577
2000-10-01T00:00:00Z