Multiscale simulations suggest a mechanism for integrin inside-out activation.
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Swing-out of the β3 hybrid domain is required for αIIbβ3 priming and normal cytoskeletal reorganization, but not adhesion to immobilized fibrinogenKey diffusion mechanisms involved in regulating bidirectional water permeation across E. coli outer membrane lectinHybrid molecular mechanics/coarse-grained simulations for structural prediction of G-protein coupled receptor/ligand complexesFine tuning inflammation at the front door: macrophage complement receptor 3-mediates phagocytosis and immune suppression for Francisella tularensisStructural heterogeneity of the μ-opioid receptor's conformational ensemble in the apo stateTalins and kindlins: partners in integrin-mediated adhesion.Membrane-induced structural rearrangement and identification of a novel membrane anchor in talin F2F3Conformational changes in talin on binding to anionic phospholipid membranes facilitate signaling by integrin transmembrane helicesTalin activates integrins by altering the topology of the β transmembrane domainBilayer asymmetry influences integrin sequestering in raft-mimicking lipid mixtures.Membrane Association of the Diphtheria Toxin Translocation Domain Studied by Coarse-Grained Simulations and ExperimentLeukocyte arrest: Biomechanics and molecular mechanisms of β2 integrin activationAtomic-level description of protein-lipid interactions using an accelerated membrane model.Sequential steps in the assembly of the multimeric outer membrane secretin PulDPerspective on the Martini model.A theoretical view of protein dynamics.Structures of the EphA2 Receptor at the Membrane: Role of Lipid Interactions.A helix heterodimer in a lipid bilayer: prediction of the structure of an integrin transmembrane domain via multiscale simulations.The Rap1-RIAM-talin axis of integrin activation and blood cell functionThe Integrin Receptor in Biologically Relevant Bilayers: Insights from Molecular Dynamics Simulations.Integrin αIIbβ3 inside-out activation: an in situ conformational analysis reveals a new mechanismTalin-driven inside-out activation mechanism of platelet αIIbβ3 integrin probed by multimicrosecond, all-atom molecular dynamics simulations.Interactions of peripheral proteins with model membranes as viewed by molecular dynamics simulations.Epigallocatechin gallate has pleiotropic effects on transmembrane signaling by altering the embedding of transmembrane domains.Mechanisms of integrin and filamin binding and their interplay with talin during early focal adhesion formation.The talin-integrin interface under mechanical stress.Changes in Cholesterol Level Alter Integrin Sequestration in Raft-Mimicking Lipid Mixtures.Role of the Helix in Talin F3 Domain (F3 Helix) in Talin-Mediated Integrin Activation.On the contributing role of the transmembrane domain for subunit-specific sensitivity of integrin activation.Transmission of integrin β7 transmembrane domain topology enables gut lymphoid tissue development.
P2860
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P2860
Multiscale simulations suggest a mechanism for integrin inside-out activation.
description
2011 nî lūn-bûn
@nan
2011 թուականի Յուլիսին հրատարակուած գիտական յօդուած
@hyw
2011 թվականի հուլիսին հրատարակված գիտական հոդված
@hy
2011年の論文
@ja
2011年論文
@yue
2011年論文
@zh-hant
2011年論文
@zh-hk
2011年論文
@zh-mo
2011年論文
@zh-tw
2011年论文
@wuu
name
Multiscale simulations suggest a mechanism for integrin inside-out activation.
@ast
Multiscale simulations suggest a mechanism for integrin inside-out activation.
@en
Multiscale simulations suggest a mechanism for integrin inside-out activation.
@en-gb
type
label
Multiscale simulations suggest a mechanism for integrin inside-out activation.
@ast
Multiscale simulations suggest a mechanism for integrin inside-out activation.
@en
Multiscale simulations suggest a mechanism for integrin inside-out activation.
@en-gb
prefLabel
Multiscale simulations suggest a mechanism for integrin inside-out activation.
@ast
Multiscale simulations suggest a mechanism for integrin inside-out activation.
@en
Multiscale simulations suggest a mechanism for integrin inside-out activation.
@en-gb
P2860
P356
P1476
Multiscale simulations suggest a mechanism for integrin inside-out activation.
@en
P2093
Iain D Campbell
Mark S P Sansom
P2860
P304
11890-11895
P356
10.1073/PNAS.1104505108
P407
P577
2011-07-05T00:00:00Z