For whom the bell tolls: protein quality control of the endoplasmic reticulum and the ubiquitin-proteasome connection.
about
Identification of PDCL3 as a novel chaperone protein involved in the generation of functional VEGF receptor 2A membrane protein required for dislocation of misfolded proteins from the ERMpl traffics to the cell surface through conventional and unconventional routesMembrane topology of the yeast endoplasmic reticulum-localized ubiquitin ligase Doa10 and comparison with its human ortholog TEB4 (MARCH-VI)Characterization of mammalian Ecm29, a 26 S proteasome-associated protein that localizes to the nucleus and membrane vesiclesCYP3A4 ubiquitination by gp78 (the tumor autocrine motility factor receptor, AMFR) and CHIP E3 ligasesHuman EDEM2, a novel homolog of family 47 glycosidases, is involved in ER-associated degradation of glycoproteinsUbiquilin and p97/VCP bind erasin, forming a complex involved in ERADBAG-2 acts as an inhibitor of the chaperone-associated ubiquitin ligase CHIP.The activity of a human endoplasmic reticulum-associated degradation E3, gp78, requires its Cue domain, RING finger, and an E2-binding siteCharacterization of an ERAD gene as VPS30/ATG6 reveals two alternative and functionally distinct protein quality control pathways: one for soluble Z variant of human alpha-1 proteinase inhibitor (A1PiZ) and another for aggregates of A1PiZ.The cochaperone HspBP1 inhibits the CHIP ubiquitin ligase and stimulates the maturation of the cystic fibrosis transmembrane conductance regulatorThe COG and COPI complexes interact to control the abundance of GEARs, a subset of Golgi integral membrane proteinsDiversity of degradation signals in the ubiquitin-proteasome systemThe cytoplasmic Hsp70 chaperone machinery subjects misfolded and endoplasmic reticulum import-incompetent proteins to degradation via the ubiquitin-proteasome systemMisfolded proteins are sorted by a sequential checkpoint mechanism of ER quality controlPreclinical evaluation of the proteasome inhibitor bortezomib in cancer therapyMisframed ubiquitin and impaired protein quality control: an early event in Alzheimer's diseaseDissecting the ER-associated degradation of a misfolded polytopic membrane protein.Previously unknown role for the ubiquitin ligase Ubr1 in endoplasmic reticulum-associated protein degradation.Sec61p is part of the endoplasmic reticulum-associated degradation machineryADD66, a gene involved in the endoplasmic reticulum-associated degradation of alpha-1-antitrypsin-Z in yeast, facilitates proteasome activity and assembly.Distinct roles for the Hsp40 and Hsp90 molecular chaperones during cystic fibrosis transmembrane conductance regulator degradation in yeast.A genomic screen identifies Dsk2p and Rad23p as essential components of ER-associated degradationMembrane-bound Ubx2 recruits Cdc48 to ubiquitin ligases and their substrates to ensure efficient ER-associated protein degradation.A receptor domain controls the intracellular sorting of the ferrichrome transporter, ARN1.The Ca2+ homeostasis defects in a pgm2Delta strain of Saccharomyces cerevisiae are caused by excessive vacuolar Ca2+ uptake mediated by the Ca2+-ATPase Pmc1p.Distinct machinery is required in Saccharomyces cerevisiae for the endoplasmic reticulum-associated degradation of a multispanning membrane protein and a soluble luminal protein.Cue1p is an activator of Ubc7p E2 activity in vitro and in vivo.Ubx4 modulates cdc48 activity and influences degradation of misfolded proteins of the endoplasmic reticulumDegradation of misfolded protein in the cytoplasm is mediated by the ubiquitin ligase Ubr1.EDEM accelerates ERAD by preventing aberrant dimer formation of misfolded alpha1-antitrypsinDegradation of the apical sodium-dependent bile acid transporter by the ubiquitin-proteasome pathway in cholangiocytesApolipoprotein B: a clinically important apolipoprotein which assembles atherogenic lipoproteins and promotes the development of atherosclerosisOverexpression of endoplasmic reticulum-resident chaperone attenuates cardiomyocyte death induced by proteasome inhibitionMolecular carcinogenesis of canine mammary tumors: news from an old diseaseERAD inhibitors integrate ER stress with an epigenetic mechanism to activate BH3-only protein NOXA in cancer cellsZebrafish whole-adult-organism chemogenomics for large-scale predictive and discovery chemical biologySynergistic apoptosis induction in leukemic cells by the phosphatase inhibitor salubrinal and proteasome inhibitorsHeat stress activates ER stress signals which suppress the heat shock response, an effect occurring preferentially in the cortex in rats
P2860
Q24296686-C86BF904-DC69-43FC-BC71-526058E3B786Q24297703-2F192CFC-AF9D-4B1C-8114-E506EA6078EAQ24299221-37B4EB9E-6B50-4A05-AC2D-2988D503EFF1Q24299616-E3D3E38E-4A99-4858-8F75-7148D34FD334Q24307896-052F13BC-0827-4C78-9060-D5EAD7344E66Q24310116-982650EE-4DF8-4A51-8EAD-38E49240F176Q24313639-A1C11BD2-0E7C-42D1-AB18-D4EAB2547210Q24324707-53041B16-452B-492C-8141-D489ACE94D96Q24534836-370BF330-5D7B-4195-A2EC-3062CC6FE445Q24535990-9A7DBBC8-1EFC-47F8-9CE0-CA5ED24FFF2FQ24537406-98D5925D-07F8-419E-AF9B-2FB81590AE1BQ24562651-454F514E-389E-48CE-B593-61CDAFBA6261Q24564894-F9C12316-001A-4E46-86C7-FE89BC753CADQ24642979-058FAA75-ACD2-4169-9D5F-B1509D865450Q24676115-6B32324E-C4FD-4792-85E2-BE0AC4750373Q24677354-F05BB267-B2DE-428D-898F-9E0156DEA311Q24814325-CDA70A67-CD03-4E56-A36B-C5C8C2F87C59Q26782999-522EE06C-F61C-4BFD-8810-05EF26844B08Q27930024-AB82013C-22BA-41AF-9235-D8994F6F25FFQ27930173-21B3F0DB-038F-490C-BFCE-40351E7F9229Q27930621-0DF8A481-9706-463A-9261-A443D6938496Q27932696-45A2A620-6A36-48FE-B25A-A89CB1610D85Q27934755-706C3123-7501-41DF-B654-7602C2F0183DQ27934931-2BB67D17-470B-4653-A85D-4910A6DEB559Q27935765-B9AF12AB-346B-453F-A7E3-5C1F3F4E6A6AQ27936416-965939E6-FC99-42FC-8CA9-93F5A39DE31DQ27937621-B23DC74F-BA73-466A-93E0-984299F06098Q27938024-CDE8FE4B-8118-42B5-8224-80A58121D92CQ27938752-3AA669D8-9C70-4F8E-8F17-7B949A0C576AQ27939043-3182F224-63B0-43A4-9586-C77273BBC5ABQ27939178-D9810693-406B-4FCD-9C62-3464FF185FF2Q28235801-01900A00-0A64-497D-88CA-104C1D1DA633Q28276520-31012756-A6A5-470A-8A0F-C4CB07D1E6EFQ28278173-AF45603C-588D-4FF6-BEE8-7DD770E7B17AQ28281770-DA730592-F350-484C-85A0-ECE4596F8A92Q28300581-A4E67C9B-80C4-47E6-9B02-BAB64A8216EBQ28307506-34C3D3D7-706A-499B-99A9-BEF2C66C84CFQ28473105-ED3DF533-A508-44E9-8D4D-D8C3570993DFQ28474489-8907F2C8-B60E-4721-AE55-EF04989A4695Q28572903-0FAA1C2A-BE42-4B13-95D7-252605FA0E2B
P2860
For whom the bell tolls: protein quality control of the endoplasmic reticulum and the ubiquitin-proteasome connection.
description
2003 nî lūn-bûn
@nan
2003 թուականի Մայիսին հրատարակուած գիտական յօդուած
@hyw
2003 թվականի մայիսին հրատարակված գիտական հոդված
@hy
2003年の論文
@ja
2003年論文
@yue
2003年論文
@zh-hant
2003年論文
@zh-hk
2003年論文
@zh-mo
2003年論文
@zh-tw
2003年论文
@wuu
name
For whom the bell tolls: prote ...... iquitin-proteasome connection.
@ast
For whom the bell tolls: prote ...... iquitin-proteasome connection.
@en
type
label
For whom the bell tolls: prote ...... iquitin-proteasome connection.
@ast
For whom the bell tolls: prote ...... iquitin-proteasome connection.
@en
prefLabel
For whom the bell tolls: prote ...... iquitin-proteasome connection.
@ast
For whom the bell tolls: prote ...... iquitin-proteasome connection.
@en
P2860
P921
P356
P1433
P1476
For whom the bell tolls: prote ...... iquitin-proteasome connection.
@en
P2093
Dieter H Wolf
Zlatka Kostova
P2860
P304
P356
10.1093/EMBOJ/CDG227
P407
P577
2003-05-01T00:00:00Z