4-aminoquinoline analogs of chloroquine with shortened side chains retain activity against chloroquine-resistant Plasmodium falciparum
about
Randomized dose-ranging controlled trial of AQ-13, a candidate antimalarial, and chloroquine in healthy volunteersMutations in the P. falciparum digestive vacuole transmembrane protein PfCRT and evidence for their role in chloroquine resistanceHematin polymerization assay as a high-throughput screen for identification of new antimalarial pharmacophores.Parallel synthesis and antimalarial screening of a 4-aminoquinoline library.Antiparasitic Sesquiterpenes from the Cameroonian Spice Scleria striatinux and Preliminary In Vitro and In Silico DMPK Assessment.Synthesis, structure-activity relationship, and mode-of-action studies of antimalarial reversed chloroquine compounds.Comparative gene expression profiling of P. falciparum malaria parasites exposed to three different histone deacetylase inhibitorsChloroquine resistance in Plasmodium falciparum malaria parasites conferred by pfcrt mutations.Antimalarial activity of the bisquinoline trans-N1,N2-bis (7-chloroquinolin-4-yl)cyclohexane-1,2-diamine: comparison of two stereoisomers and detailed evaluation of the S,S enantiomer, Ro 47-7737Dictyostelium discoideum expresses a malaria chloroquine resistance mechanism upon transfection with mutant, but not wild-type, Plasmodium falciparum transporter PfCRT.Identification of β-hematin inhibitors in the MMV Malaria BoxSontochin as a guide to the development of drugs against chloroquine-resistant malaria.Novel 4-aminoquinoline analogs highly active against the blood and sexual stages of Plasmodium in vivo and in vitroSynthesis and antimalarial activity of new chloroquine analogues carrying a multifunctional linear side chain.The development and validation of an LC-MS/MS method for the determination of a new anti-malarial compound (TK900D) in human whole blood and its application to pharmacokinetic studies in mice.In vitro antimalarial activity of a new organometallic analog, ferrocene-chloroquine4-N-, 4-S-, and 4-O-chloroquine analogues: influence of side chain length and quinolyl nitrogen pKa on activity vs chloroquine resistant malaria.Synthesis and Evaluation of Chirally Defined Side Chain Variants of 7-Chloro-4-Aminoquinoline To Overcome Drug Resistance in Malaria Chemotherapy.Metallocene antimalarials: the continuing questOvercoming drug resistance to heme-targeted antimalarials by systematic side chain variation of 7-chloro-4-aminoquinolines.Incorporation of an intramolecular hydrogen-bonding motif in the side chain of 4-aminoquinolines enhances activity against drug-resistant P. falciparum.Isolation and identification of an antiparasitic triterpenoid estersaponin from the stem bark of Pittosporum mannii (Pittosporaceae).
P2860
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P2860
4-aminoquinoline analogs of chloroquine with shortened side chains retain activity against chloroquine-resistant Plasmodium falciparum
description
1996 nî lūn-bûn
@nan
1996 թուականի Օգոստոսին հրատարակուած գիտական յօդուած
@hyw
1996 թվականի օգոստոսին հրատարակված գիտական հոդված
@hy
1996年の論文
@ja
1996年論文
@yue
1996年論文
@zh-hant
1996年論文
@zh-hk
1996年論文
@zh-mo
1996年論文
@zh-tw
1996年论文
@wuu
name
4-aminoquinoline analogs of ch ...... esistant Plasmodium falciparum
@ast
4-aminoquinoline analogs of ch ...... esistant Plasmodium falciparum
@en
type
label
4-aminoquinoline analogs of ch ...... esistant Plasmodium falciparum
@ast
4-aminoquinoline analogs of ch ...... esistant Plasmodium falciparum
@en
prefLabel
4-aminoquinoline analogs of ch ...... esistant Plasmodium falciparum
@ast
4-aminoquinoline analogs of ch ...... esistant Plasmodium falciparum
@en
P2093
P2860
P1476
4-aminoquinoline analogs of ch ...... esistant Plasmodium falciparum
@en
P2093
Girometta MA
Hofheinz W
Masciadri R
P2860
P304
P407
P577
1996-08-01T00:00:00Z