Targeting vascular pericytes in hypoxic tumors increases lung metastasis via angiopoietin-2. - Wikidata - awgldk - TriplyDB

Targeting vascular pericytes in hypoxic tumors increases lung metastasis via angiopoietin-2.

Targeting vascular pericytes in hypoxic tumors increases lung metastasis via angiopoietin-2.

http://www.wikidata.org/entity/Q35126158

about

The ever-expanding role of HIF in tumour and stromal biology Plastic roles of pericytes in the blood-retinal barrier.Dual role of pericyte α6β1-integrin in tumour blood vessels.Epithelial-to-mesenchymal transition is dispensable for metastasis but induces chemoresistance in pancreatic cancer.Interleukin-6 Stimulates Defective Angiogenesis.Association of Angiopoietin-2 and Ki-67 Expression with Vascular Density and Sunitinib Response in Metastatic Renal Cell Carcinoma.The challenge of targeting metastasis.Dual inhibition of Ang-2 and VEGF receptors normalizes tumor vasculature and prolongs survival in glioblastoma by altering macrophages.Ang-2/VEGF bispecific antibody reprograms macrophages and resident microglia to anti-tumor phenotype and prolongs glioblastoma survival.Anti-tumoral, anti-angiogenic and anti-metastatic efficacy of a tetravalent bispecific antibody (TAvi6) targeting VEGF-A and angiopoietin-2.Heterogeneous perivascular cell coverage affects breast cancer metastasis and response to chemotherapy The Role of the Tumor Vasculature in the Host Immune Response: Implications for Therapeutic Strategies Targeting the Tumor Microenvironment.Sunitinib Treatment Enhances Metastasis of Innately Drug-Resistant Breast Tumors.Tumor microenvironment: driving forces and potential therapeutic targets for breast cancer metastasis Imaging the Tumor Microenvironment.Targeted complement inhibition and microvasculature in transplants: a therapeutic perspective.Pericyte-expressed Tie2 controls angiogenesis and vessel maturation.Nanoparticle design strategies for enhanced anticancer therapy by exploiting the tumour microenvironment.Accelerated tumour metastasis due to interferon-γ receptor-mediated dissociation of perivascular cells from blood vessels.Pericyte-targeting prodrug overcomes tumor resistance to vascular disrupting agents.Angiopoietin pathway gene expression associated with poor breast cancer survival.Perivascular PDGFR-β is an independent marker for prognosis in renal cell carcinoma.Therapeutic targeting of the angiopoietin-TIE pathway.Microenvironmental regulation of tumour angiogenesis.Platelet "first responders" in wound response, cancer, and metastasis.Survival-associated heterogeneity of marker-defined perivascular cells in colorectal cancer Vascular Mimicry: The Next Big Glioblastoma Target.Therapeutic uses of epicatechin in diabetes and cancer.Increased PD-L1 expression and IL-6 secretion characterize human lung tumor-derived perivascular-like cells that promote vascular leakage in a perfusable microvasculature model.Demethylation of the MIR145 promoter suppresses migration and invasion in breast cancer.Efficacy of Cotargeting Angiopoietin-2 and the VEGF Pathway in the Adjuvant Postsurgical Setting for Early Breast, Colorectal, and Renal Cancers.Inhibition of Lysyl Oxidases Impairs Migration and Angiogenic Properties of Tumor-Associated Pericytes.KLF4-dependent perivascular cell plasticity mediates pre-metastatic niche formation and metastasis.Vascular abnormalities and development of hypoxia in microscopic melanoma xenografts.Hypoxia inducible factor (HIF) in the tumor microenvironment: friend or foe?PDGFRβ-P2A-CreERT2 mice: a genetic tool to target pericytes in angiogenesis.Gradual Suppression of Transcytosis Governs Functional Blood-Retinal Barrier Formation.Tissue-Dependent Tumor Microenvironments and Their Impact on Immunotherapy Responses.The Selective Tie2 Inhibitor Rebastinib Blocks Recruitment and Function of Tie2Hi Macrophages in Breast Cancer and Pancreatic Neuroendocrine Tumors.The role of tumor microenvironment in resistance to anti-angiogenic therapy.

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Targeting vascular pericytes in hypoxic tumors increases lung metastasis via angiopoietin-2.

http://www.wikidata.org/entity/Q35126158

description

2015 nî lūn-bûn

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2015 թուականի Փետրուարին հրատարակուած գիտական յօդուած

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2015 թվականի փետրվարին հրատարակված գիտական հոդված

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2015年の論文

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J.CELREP.2015.01.035

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Targeting vascular pericytes i ...... metastasis via angiopoietin-2

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Chenghua Gu

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Doruk Keskin

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Hikaru Sugimoto

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Jiha Kim

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Michele De Palma

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Raghu Kalluri

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Valerie S LeBleu

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Vesselina G Cooke

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P2860

Involvement of chemokine receptors in breast cancer metastasis

Endostatin: an endogenous inhibitor of angiogenesis and tumor growth

Antiangiogenic therapy elicits malignant progression of tumors to increased local invasion and distant metastasis

Benefits of targeting both pericytes and endothelial cells in the tumor vasculature with kinase inhibitors

The role of pericytes in blood-vessel formation and maintenance

Pericytes: developmental, physiological, and pathological perspectives, problems, and promises

Leakage-resistant blood vessels in mice transgenically overexpressing angiopoietin-1

Molecular mechanisms and clinical applications of angiogenesis

Normalization of tumor vasculature: an emerging concept in antiangiogenic therapy

Role of angiogenesis in tumor growth and metastasis

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