Glucagon receptor antibody completely suppresses type 1 diabetes phenotype without insulin by disrupting a novel diabetogenic pathway
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Skeletal muscle as a therapeutic target for delaying type 1 diabetic complicationsGlucagon receptor gene deletion in insulin knockout mice modestly reduces blood glucose and ketones but does not promote survivalAn AlphaScreen Assay for the Discovery of Synthetic Chemical Inhibitors of Glucagon ProductionInhibition of Cellular Adhesion by Immunological Targeting of Osteopontin Neoepitopes Generated through Matrix Metalloproteinase and Thrombin CleavageAdiponectin, Leptin, and Fatty Acids in the Maintenance of Metabolic Homeostasis through Adipose Tissue Crosstalk.Blockade of glucagon signaling prevents or reverses diabetes onset only if residual β-cells persist.Oligofructose as an adjunct in treatment of diabetes in NOD mice.Islet α cells and glucagon--critical regulators of energy homeostasis.Inhibiting or antagonizing glucagon: making progress in diabetes care.Evolving function and potential of pancreatic alpha cells.Glucagon therapeutics, dawn of a new era for diabetes care.Hypoglycemic Effect of Combined Ghrelin and Glucagon Receptor Blockade.Glucose control of glucagon secretion-'There's a brand-new gimmick every year'.Glucagon is the key factor in the development of diabetes.Angptl4 does not control hyperglucagonemia or α-cell hyperplasia following glucagon receptor inhibition.Glucagon receptor inhibition normalizes blood glucose in severe insulin-resistant mice.Opportunities for therapeutic antibodies directed at G-protein-coupled receptors.A cullin 4B-RING E3 ligase complex fine-tunes pancreatic δ cell paracrine interactions.The glucoregulatory actions of leptin.Glucagon antagonism in islet cell proliferation.Lipid nanoparticle delivery of glucagon receptor siRNA improves glucose homeostasis in mouse models of diabetesInternational Diabetes Federation World Diabetes Congress 2015.Investigational glucagon receptor antagonists in Phase I and II clinical trials for diabetes.Glucagon Receptor Antagonism Improves Glucose Metabolism and Cardiac Function by Promoting AMP-Mediated Protein Kinase in Diabetic Mice.Reduced islet function contributes to impaired glucose homeostasis in fructose-fed mice.Dapagliflozin suppresses glucagon signaling in rodent models of diabetes.The biology of glucagon and the consequences of hyperglucagonemia.Clinical Trials, Triumphs, and Tribulations of Glucagon Receptor Antagonists.Acute disruption of glucagon secretion or action does not improve glucose tolerance in an insulin-deficient mouse model of diabetes.Chronic fractalkine administration improves glucose tolerance and pancreatic endocrine function.Neutrophils Release Metalloproteinases during Adhesion in the Presence of Insulin, but Cathepsin G in the Presence of Glucagon.Deletion of the glucagon receptor gene before and after experimental diabetes reveals differential protection from hyperglycemia
P2860
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P2860
Glucagon receptor antibody completely suppresses type 1 diabetes phenotype without insulin by disrupting a novel diabetogenic pathway
description
2015 nî lūn-bûn
@nan
2015 թուականի Փետրուարին հրատարակուած գիտական յօդուած
@hyw
2015 թվականի փետրվարին հրատարակված գիտական հոդված
@hy
2015年の論文
@ja
2015年論文
@yue
2015年論文
@zh-hant
2015年論文
@zh-hk
2015年論文
@zh-mo
2015年論文
@zh-tw
2015年论文
@wuu
name
Glucagon receptor antibody com ...... g a novel diabetogenic pathway
@ast
Glucagon receptor antibody com ...... g a novel diabetogenic pathway
@en
type
label
Glucagon receptor antibody com ...... g a novel diabetogenic pathway
@ast
Glucagon receptor antibody com ...... g a novel diabetogenic pathway
@en
prefLabel
Glucagon receptor antibody com ...... g a novel diabetogenic pathway
@ast
Glucagon receptor antibody com ...... g a novel diabetogenic pathway
@en
P2093
P2860
P921
P356
P1476
Glucagon receptor antibody com ...... g a novel diabetogenic pathway
@en
P2093
Annie Williams
Jacques Philippe
Matthew R Evans
May-Yun Wang
Roger H Unger
Shiuhwei Chen
Zhiqing Shi
P2860
P304
P356
10.1073/PNAS.1424934112
P407
P50
P577
2015-02-09T00:00:00Z