NAMPT (visfatin), a direct target of hypoxia-inducible factor-2α, is an essential catabolic regulator of osteoarthritis - Wikidata - awgldk - TriplyDB

NAMPT (visfatin), a direct target of hypoxia-inducible factor-2α, is an essential catabolic regulator of osteoarthritis

NAMPT (visfatin), a direct target of hypoxia-inducible factor-2α, is an essential catabolic regulator of osteoarthritis

http://www.wikidata.org/entity/Q35135460

about

The Regulatory Role of Signaling Crosstalk in Hypertrophy of MSCs and Human Articular Chondrocytes Epigenetic Regulation of Chondrocyte Catabolism and Anabolism in Osteoarthritis Insights on Molecular Mechanisms of Chondrocytes Death in Osteoarthritis Adipokine Contribution to the Pathogenesis of Osteoarthritis.FK866 attenuates acute hepatic failure through c-jun-N-terminal kinase (JNK)-dependent autophagy Hypoxia-inducible factor-2α is an essential catabolic regulator of inflammatory rheumatoid arthritis.IL-6 secretion in osteoarthritis patients is mediated by chondrocyte-synovial fibroblast cross-talk and is enhanced by obesity Low-grade inflammation as a key mediator of the pathogenesis of osteoarthritis.Biologic basis of osteoarthritis: state of the evidence Pleiotropic Functions of High Fat Diet in the Etiology of Osteoarthritis.Genome-wide association study of dental caries in the Hispanic Communities Health Study/Study of Latinos (HCHS/SOL)Pleiotropic roles of metallothioneins as regulators of chondrocyte apoptosis and catabolic and anabolic pathways during osteoarthritis pathogenesis.Nicotinamide phosphoribosyltransferase inhibits receptor activator of nuclear factor-κB ligand-induced osteoclast differentiation in vitro.The current progress in understanding the molecular functions and mechanisms of visfatin in osteoarthritis.AMPK and HIF signaling pathways regulate both longevity and cancer growth: the good news and the bad news about survival mechanisms.The Role of Sirtuins in Cartilage Homeostasis and Osteoarthritis.Analysis of the nicotinamide phosphoribosyltransferase family provides insight into vertebrate adaptation to different oxygen levels during the water-to-land transition.Melatonin inhibits Sirt1-dependent NAMPT and NFAT5 signaling in chondrocytes to attenuate osteoarthritis.NAMPT enzyme activity regulates catabolic gene expression in gingival fibroblasts during periodontitis.Estrogen-related receptor γ causes osteoarthritis by upregulating extracellular matrix-degrading enzymes.NAMPT Is an Essential Regulator of RA-Mediated Periodontal Inflammation.3'-Sialyllactose protects against osteoarthritic development by facilitating cartilage homeostasis.MicroRNA-365 regulates IL-1β-induced catabolic factor expression by targeting HIF-2α in primary chondrocytes.

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P2860

NAMPT (visfatin), a direct target of hypoxia-inducible factor-2α, is an essential catabolic regulator of osteoarthritis

http://www.wikidata.org/entity/Q35135460

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2013 nî lūn-bûn

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2013 թուականի Դեկտեմբերին հրատարակուած գիտական յօդուած

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2013 թվականի դեկտեմբերին հրատարակված գիտական հոդված

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2013年の論文

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2013年論文

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2013年論文

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2013年論文

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2013年論文

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2013年論文

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2013年论文

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ANNRHEUMDIS-2013-204355

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Annals of the Rheumatic Diseases

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NAMPT (visfatin), a direct tar ...... ic regulator of osteoarthritis

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Churl-Hong Chun

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Hwanhee Oh

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Hyun Ah Kim

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Jang-Soo Chun

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Je-Hwang Ryu

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Ji-Sun Kwak

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Jimin Jeon

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Jin-Hong Kim

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Siyoung Yang

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P2860

Pharmacological inhibition of nicotinamide phosphoribosyltransferase/visfatin enzymatic activity identifies a new inflammatory pathway linked to NAD

Matrix metalloproteinase 13-deficient mice are resistant to osteoarthritic cartilage erosion but not chondrocyte hypertrophy or osteophyte development.

Adipocytokines are associated with radiographic joint damage in rheumatoid arthritis.

The STR/ort mouse and its use as a model of osteoarthritis.

Molecular basis for the inhibition of human NMPRTase, a novel target for anticancer agents.

Hypoxia increases sirtuin 1 expression in a hypoxia-inducible factor-dependent manner.

Dissecting systemic control of metabolism and aging in the NAD World: the importance of SIRT1 and NAMPT-mediated NAD biosynthesis.

Nicotinamide phosphoribosyltransferase is essential for interleukin-1beta-mediated dedifferentiation of articular chondrocytes via SIRT1 and extracellular signal-regulated kinase (ERK) complex signaling

Nicotinamide Phosphoribosyltransferase in Human Diseases.

Changes in plasma levels of fat-derived hormones adiponectin, leptin, resistin and visfatin in patients with rheumatoid arthritis.

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