Dynamic regulation of FGF23 by Fam20C phosphorylation, GalNAc-T3 glycosylation, and furin proteolysis - Wikidata - awgldk - TriplyDB

Dynamic regulation of FGF23 by Fam20C phosphorylation, GalNAc-T3 glycosylation, and furin proteolysis

Dynamic regulation of FGF23 by Fam20C phosphorylation, GalNAc-T3 glycosylation, and furin proteolysis

http://www.wikidata.org/entity/Q35140676

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A secretory kinase complex regulates extracellular protein phosphorylation A Single Kinase Generates the Majority of the Secreted Phosphoproteome A unified model for bone-renal mineral and energy metabolism The secretory pathway kinases Dysregulation of phosphate metabolism and conditions associated with phosphate toxicity PHEX mimetic (SPR4-peptide) corrects and improves HYP and wild type mice energy-metabolism Inhibitor of ppGalNAc-T3-mediated O-glycosylation blocks cancer cell invasiveness and lowers FGF23 levels.Specific ablation of mouse Fam20C in cells expressing type I collagen leads to skeletal defects and hypophosphatemia.Hypophosphatemic rickets: revealing novel control points for phosphate homeostasis.Development of isoform-specific sensors of polypeptide GalNAc-transferase activity.Phosphorylation and Alternative Splicing of 7B2 Reduce Prohormone Convertase 2 Activation High-throughput screening of mouse gene knockouts identifies established and novel skeletal phenotypes.Hereditary hypophosphatemia in Norway: a retrospective population-based study of genotypes, phenotypes, and treatment complications.Parathyroid hormone 1 receptor is essential to induce FGF23 production and maintain systemic mineral ion homeostasis.Family with sequence similarity member 20C is the primary but not the only kinase for the small-integrin-binding ligand N-linked glycoproteins in bone Impact of Phosphorus-Based Food Additives on Bone and Mineral Metabolism.Influenza A Virus-Induced Expression of a GalNAc Transferase, GALNT3, via MicroRNAs Is Required for Enhanced Viral Replication.FGF23 is endogenously phosphorylated in bone cells.Effects of acute kidney injury and chronic hypoxemia on fibroblast growth factor 23 levels in pediatric cardiac surgery patients.Systemic Control of Bone Homeostasis by FGF23 Signaling.O-Glycosylation of a Secretory Granule Membrane Enzyme Is Essential for Its Endocytic Trafficking 1,25-Dihydroxyvitamin D Alone Improves Skeletal Growth, Microarchitecture, and Strength in a Murine Model of XLH, Despite Enhanced FGF23 Expression.Phosphorylation of spore coat proteins by a family of atypical protein kinases.Immortalized Mouse Floxed Fam20c Dental Papillar Mesenchymal and Osteoblast Cell Lines Retain Their Primary Characteristics.Inflammation regulates fibroblast growth factor 23 production.Multiple faces of fibroblast growth factor-23 Counter-regulatory paracrine actions of FGF-23 and 1,25(OH)2 D in macrophages.Raine Syndrome (OMIM #259775), Caused By FAM20C Mutation, Is Congenital Sclerosing Osteomalacia With Cerebral Calcification (OMIM 259660).Systematic network-based discovery of a Fam20C inhibitor (FL-1607) with apoptosis modulation in triple-negative breast cancer.Posttranslational processing of FGF23 in osteocytes during the osteoblast to osteocyte transition.The PTH-Vitamin D-FGF23 axis.Casein kinases as potential therapeutic targets.Fam20C is under the control of sphingolipid signaling in human cell lines.Extracellular Protein Phosphorylation, the Neglected Side of the Modification.Ironing out the cross talk between FGF23 and inflammation.Excess APP O-glycosylation by GalNAc-T6 decreases Aβ production.Heritable and acquired disorders of phosphate metabolism: Etiologies involving FGF23 and current therapeutics.Overexpression of Dmp1 fails to rescue the bone and dentin defects in Fam20C knockout mice.PAI-1 is a critical regulator of FGF23 homeostasis Genetic Ablation of Fgf23 or Klotho Does not Modulate Experimental Heart Hypertrophy Induced by Pressure Overload.

P2860

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P2860

Dynamic regulation of FGF23 by Fam20C phosphorylation, GalNAc-T3 glycosylation, and furin proteolysis

http://www.wikidata.org/entity/Q35140676

description

2014 nî lūn-bûn

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2014 թուականի Մարտին հրատարակուած գիտական յօդուած

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2014 թվականի մարտին հրատարակված գիտական հոդված

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2014年の論文

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2014年論文

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2014年論文

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2014年論文

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2014年論文

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2014年論文

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2014年论文

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Dynamic regulation of FGF23 by ...... ylation, and furin proteolysis

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Dynamic regulation of FGF23 by ...... ylation, and furin proteolysis

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Dynamic regulation of FGF23 by ...... ylation, and furin proteolysis

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Dynamic regulation of FGF23 by ...... ylation, and furin proteolysis

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Dynamic regulation of FGF23 by ...... ylation, and furin proteolysis

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P1433

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PNAS.1402218111

P1433

Proceedings of the National Academy of Sciences of the United States of America

P1476

Dynamic regulation of FGF23 by ...... ylation, and furin proteolysis

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P2093

Antonius Koller

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David J Gonzalez

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Hitesh Nidumanda Appaiah

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Jack E Dixon

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James L Engel

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Junyu Xiao

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Kenneth E White

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Vincent S Tagliabracci

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P2860

Inactivation of a novel FGF23 regulator, FAM20C, leads to hypophosphatemic rickets in mice

Autosomal dominant hypophosphataemic rickets is associated with mutations in FGF23

Crystal structure of the Golgi casein kinase

A gene (PEX) with homologies to endopeptidases is mutated in patients with X-linked hypophosphatemic rickets. The HYP Consortium

Polypeptide GalNAc-transferase T3 and familial tumoral calcinosis. Secretion of fibroblast growth factor 23 requires O-glycosylation

Secreted kinase phosphorylates extracellular proteins that regulate biomineralization

Unknown syndrome: microcephaly, hypoplastic nose, exophthalmos, gum hyperplasia, cleft palate, low set ears, and osteosclerosis

Multiplex genome engineering using CRISPR/Cas systems

Secreted protein kinases

Mutations in FAM20C are associated with lethal osteosclerotic bone dysplasia (Raine syndrome), highlighting a crucial molecule in bone development

P304

5520-5525

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P356

10.1073/PNAS.1402218111

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15

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111

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2014-03-26T00:00:00Z

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261409940

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24706917

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phosphorylation

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3992636

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