Small-molecule probes targeting the viral PPxY-host Nedd4 interface block egress of a broad range of RNA viruses. - Wikidata - awgldk - TriplyDB

Small-molecule probes targeting the viral PPxY-host Nedd4 interface block egress of a broad range of RNA viruses.

Small-molecule probes targeting the viral PPxY-host Nedd4 interface block egress of a broad range of RNA viruses.

http://www.wikidata.org/entity/Q35150964

about

E3 Ubiquitin Ligase NEDD4 Promotes Influenza Virus Infection by Decreasing Levels of the Antiviral Protein IFITM3 Calcium Regulation of Hemorrhagic Fever Virus Budding: Mechanistic Implications for Host-Oriented Therapeutic Intervention Nipah virus matrix protein: expert hacker of cellular machines.The multifunctional Ebola virus VP40 matrix protein is a promising therapeutic target.E3 Ubiquitin Ligases Neurobiological Mechanisms: Development to Degeneration Small molecules with antiviral activity against the Ebola virus Influence of cellular trafficking pathway on bluetongue virus infection in ovine cells Machine learning models identify molecules active against the Ebola virus in vitro ALIX Rescues Budding of a Double PTAP/PPEY L-Domain Deletion Mutant of Ebola VP40: A Role for ALIX in Ebola Virus Egress.Covalent Tethering of Fragments For Covalent Probe Discovery Chaperone-Mediated Autophagy Protein BAG3 Negatively Regulates Ebola and Marburg VP40-Mediated Egress.A Small Molecule That Switches a Ubiquitin Ligase From a Processive to a Distributive Enzymatic Mechanism Replacement of the hepatitis E virus ORF3 protein PxxP motif with heterologous late domain motifs affects virus release via interaction with TSG101 ITCH E3 Ubiquitin Ligase Interacts with Ebola Virus VP40 To Regulate Budding.Development of Small-Molecule Antivirals for Ebola.Ubiquitin Ligase WWP1 Interacts with Ebola Virus VP40 to Regulate Egress.Paving the way to targeting HECT ubiquitin ligases.Therapeutics for postexposure treatment of Ebola virus infection.Ubiquitination and the Regulation of Membrane Proteins.Matrix proteins of Nipah and Hendra viruses interact with beta subunits of AP-3 complexes.A Review of Functional Motifs Utilized by Viruses.Quinoxaline-based inhibitors of Ebola and Marburg VP40 egress.A common feature pharmacophore for FDA-approved drugs inhibiting the Ebola virus.Hemorrhagic Fever Virus Budding Studies.A Systematic Review of Computational Drug Discovery, Development, and Repurposing for Ebola Virus Disease Treatment.

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P2860

Small-molecule probes targeting the viral PPxY-host Nedd4 interface block egress of a broad range of RNA viruses.

http://www.wikidata.org/entity/Q35150964

description

2014 nî lūn-bûn

@nan

2014 թուականի Ապրիլին հրատարակուած գիտական յօդուած

@hyw

2014 թվականի ապրիլին հրատարակված գիտական հոդված

@hy

2014年の論文

@ja

2014年論文

@yue

2014年論文

@zh-hant

2014年論文

@zh-hk

2014年論文

@zh-mo

2014年論文

@zh-tw

2014年论文

@wuu

name

Small-molecule probes targetin ...... a broad range of RNA viruses.

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Small-molecule probes targetin ...... a broad range of RNA viruses.

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type

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Small-molecule probes targetin ...... a broad range of RNA viruses.

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Small-molecule probes targetin ...... a broad range of RNA viruses.

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prefLabel

Small-molecule probes targetin ...... a broad range of RNA viruses.

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Small-molecule probes targetin ...... a broad range of RNA viruses.

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P1433

Journal of Virology

P1476

Small-molecule probes targetin ...... a broad range of RNA viruses.

@en

P2093

Allen B Reitz

http://www.w3.org/2001/XMLSchema#string

Benjamin Davis

http://www.w3.org/2001/XMLSchema#string

Bruce D Freedman

http://www.w3.org/2001/XMLSchema#string

Gordon Ruthel

http://www.w3.org/2001/XMLSchema#string

Jay E Wrobel

http://www.w3.org/2001/XMLSchema#string

Jianhong Lu

http://www.w3.org/2001/XMLSchema#string

Mark A Olson

http://www.w3.org/2001/XMLSchema#string

Matthias J Schnell

http://www.w3.org/2001/XMLSchema#string

Michael S Lee

http://www.w3.org/2001/XMLSchema#string

Ronald N Harty

http://www.w3.org/2001/XMLSchema#string

P2860

Infectious Lassa virus, but not filoviruses, is restricted by BST-2/tetherin

ISG15 inhibits Ebola VP40 VLP budding in an L-domain-dependent manner by blocking Nedd4 ligase activity

Nedd4.1-mediated ubiquitination and subsequent recruitment of Tsg101 ensure HTLV-1 Gag trafficking towards the multivesicular body pathway prior to virus budding

Overexpression of the N-terminal domain of TSG101 inhibits HIV-1 budding by blocking late domain function

Overlapping motifs (PTAP and PPEY) within the Ebola virus VP40 protein function independently as late budding domains: involvement of host proteins TSG101 and VPS-4.

Proteins related to the Nedd4 family of ubiquitin protein ligases interact with the L domain of Rous sarcoma virus and are required for gag budding from cells

The ESCRT-associated protein Alix recruits the ubiquitin ligase Nedd4-1 to facilitate HIV-1 release through the LYPXnL L domain motif

A role for ubiquitin ligase recruitment in retrovirus release

ISG15 inhibits Nedd4 ubiquitin E3 activity and enhances the innate antiviral response

CHARMM: the biomolecular simulation program

P304

7294-7306

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scholarly article

P356

10.1128/JVI.00591-14

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13

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88

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