ZEB2 drives immature T-cell lymphoblastic leukaemia development via enhanced tumour-initiating potential and IL-7 receptor signalling.
about
Novel ZEB2-BCL11B Fusion Gene Identified by RNA-Sequencing in Acute Myeloid Leukemia with t(2;14)(q22;q32)PAX5 is a tumor suppressor in mouse mutagenesis models of acute lymphoblastic leukemia.Transcriptional repressor ZEB2 promotes terminal differentiation of CD8+ effector and memory T cell populations during infection.Deletions of the long arm of chromosome 5 define subgroups of T-cell acute lymphoblastic leukemiaHaploinsufficiency for NR3C1, the gene encoding the glucocorticoid receptor, in blastic plasmacytoid dendritic cell neoplasms.A directly negative interaction of miR-203 and ZEB2 modulates tumor stemness and chemotherapy resistance in nasopharyngeal carcinoma.Oncogenic ZEB2 activation drives sensitivity toward KDM1A inhibition in T-cell acute lymphoblastic leukemia.Direct interaction between miR-203 and ZEB2 suppresses epithelial-mesenchymal transition signaling and reduces lung adenocarcinoma chemoresistance.The EMT regulator ZEB2 is a novel dependency of human and murine acute myeloid leukemia.The genetics and molecular biology of T-ALL.Hypoxia inducible factor-1α regulates a pro-invasive phenotype in acute monocytic leukemiaOptimal interleukin-7 receptor-mediated signaling, cell cycle progression and viability of T-cell acute lymphoblastic leukemia cells rely on casein kinase 2 activity.Aberrant Signaling Pathways in T-Cell Acute Lymphoblastic Leukemia.The molecular landscape of pediatric acute myeloid leukemia reveals recurrent structural alterations and age-specific mutational interactions.The T-cell leukemia-associated ribosomal RPL10 R98S mutation enhances JAK-STAT signaling.New Challenges in Targeting Signaling Pathways in Acute Lymphoblastic Leukemia by NGS Approaches: An Update.Phosphoproteomic analysis reveals hyperactivation of mTOR/STAT3 and LCK/Calcineurin axes in pediatric early T-cell precursor ALL.Expressed repetitive elements are broadly applicable reference targets for normalization of reverse transcription-qPCR data in mice.
P2860
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P2860
ZEB2 drives immature T-cell lymphoblastic leukaemia development via enhanced tumour-initiating potential and IL-7 receptor signalling.
description
2015 nî lūn-bûn
@nan
2015 թուականի Յունուարին հրատարակուած գիտական յօդուած
@hyw
2015 թվականի հունվարին հրատարակված գիտական հոդված
@hy
2015年の論文
@ja
2015年論文
@yue
2015年論文
@zh-hant
2015年論文
@zh-hk
2015年論文
@zh-mo
2015年論文
@zh-tw
2015年论文
@wuu
name
ZEB2 drives immature T-cell ly ...... and IL-7 receptor signalling.
@ast
ZEB2 drives immature T-cell ly ...... and IL-7 receptor signalling.
@en
type
label
ZEB2 drives immature T-cell ly ...... and IL-7 receptor signalling.
@ast
ZEB2 drives immature T-cell ly ...... and IL-7 receptor signalling.
@en
prefLabel
ZEB2 drives immature T-cell ly ...... and IL-7 receptor signalling.
@ast
ZEB2 drives immature T-cell ly ...... and IL-7 receptor signalling.
@en
P2093
P2860
P50
P356
P1476
ZEB2 drives immature T-cell ly ...... l and IL-7 receptor signalling
@en
P2093
Adam Rickard
Ananda W Goldrath
Cedric S Tremblay
Claire Schwab
Emmanuelle Clappier
Enrico Radaelli
Filip Matthijssens
J Adam Best
Jean Soulier
Jelle De Medts
P2860
P2888
P356
10.1038/NCOMMS6794
P407
P50
P577
2015-01-07T00:00:00Z