Irgm1 protects hematopoietic stem cells by negative regulation of IFN signaling - Wikidata - awgldk - TriplyDB

Irgm1 protects hematopoietic stem cells by negative regulation of IFN signaling

Irgm1 protects hematopoietic stem cells by negative regulation of IFN signaling

http://www.wikidata.org/entity/Q35164256

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Hematopoietic Stem Cell Regulation by Type I and II Interferons in the Pathogenesis of Acquired Aplastic Anemia Stress and Non-Stress Roles of Inflammatory Signals during HSC Emergence and Maintenance Ruxolitinib in the treatment of polycythemia vera: patient selection and special considerations Impact of Viral Infections on Hematopoiesis: From Beneficial to Detrimental Effects on Bone Marrow Output Genetic engineering of hematopoiesis for targeted IFN-α delivery inhibits breast cancer progression Ataxin1L is a regulator of HSC function highlighting the utility of cross-tissue comparisons for gene discovery Imprinted genes that regulate early mammalian growth are coexpressed in somatic stem cells.Type II interferon promotes differentiation of myeloid-biased hematopoietic stem cells.Type I interferons link viral infection to enhanced epithelial turnover and repair.Lack of the ubiquitin-editing enzyme A20 results in loss of hematopoietic stem cell quiescence Palmitoylation of the immunity related GTPase, Irgm1: impact on membrane localization and ability to promote mitochondrial fission Viruses, autophagy genes, and Crohn's disease.IRGM1 enhances B16 melanoma cell metastasis through PI3K-Rac1 mediated epithelial mesenchymal transition.Loss of the interferon-γ-inducible regulatory immunity-related GTPase (IRG), Irgm1, causes activation of effector IRG proteins on lysosomes, damaging lysosomal function and predicting the dramatic susceptibility of Irgm1-deficient mice to infection.IFN-γ elicits macrophage autophagy via the p38 MAPK signaling pathway.Comparative long-term effects of interferon α and hydroxyurea on human hematopoietic progenitor cells.Immune-related GTPase M (IRGM1) regulates neuronal autophagy in a mouse model of stroke Depletion of Jak2V617F myeloproliferative neoplasm-propagating stem cells by interferon-α in a murine model of polycythemia vera IRGM1 regulates oxidized LDL uptake by macrophage via actin-dependent receptor internalization during atherosclerosis.Investigation of the role of interleukin-6 and hepcidin antimicrobial peptide in the development of anemia with age.Re-entry into quiescence protects hematopoietic stem cells from the killing effect of chronic exposure to type I interferons.Less is more: unveiling the functional core of hematopoietic stem cells through knockout mice.Pro-inflammatory cytokines: emerging players regulating HSC function in normal and diseased hematopoiesis.Irgm1 (LRG-47), a regulator of cell-autonomous immunity, does not localize to mycobacterial or listerial phagosomes in IFN-γ-induced mouse cells.Inflammation: a key regulator of hematopoietic stem cell fate in health and disease.Metabolic Alterations Contribute to Enhanced Inflammatory Cytokine Production in Irgm1-deficient Macrophages.Chronic Infection Depletes Hematopoietic Stem Cells through Stress-Induced Terminal Differentiation.Interferon gamma signaling positively regulates hematopoietic stem cell emergence.Mutation of STAT1/3 binding sites in gp130(FXXQ) knock-in mice does not alter hematopoietic stem cell repopulation or self-renewal potential Murine Oncostatin M Acts via Leukemia Inhibitory Factor Receptor to Phosphorylate Signal Transducer and Activator of Transcription 3 (STAT3) but Not STAT1, an Effect That Protects Bone Mass G-CSF regulates hematopoietic stem cell activity, in part, through activation of Toll-like receptor signaling.Integrin αvβ3 enhances the suppressive effect of interferon-γ on hematopoietic stem cells.Regulation of myelopoiesis by proinflammatory cytokines in infectious diseases.NR4A1 and NR4A3 restrict HSC proliferation via reciprocal regulation of C/EBPα and inflammatory signaling.Hematopoietic stem cells, infection, and the niche.

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P2860

Irgm1 protects hematopoietic stem cells by negative regulation of IFN signaling

http://www.wikidata.org/entity/Q35164256

description

2011 nî lūn-bûn

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2011 թուականի Յունիսին հրատարակուած գիտական յօդուած

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2011 թվականի հունիսին հրատարակված գիտական հոդված

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2011年の論文

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2011年論文

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2011年論文

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2011年論文

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2011年論文

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2011年論文

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2011年论文

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name

Irgm1 protects hematopoietic stem cells by negative regulation of IFN signaling

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Irgm1 protects hematopoietic stem cells by negative regulation of IFN signaling

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type

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Irgm1 protects hematopoietic stem cells by negative regulation of IFN signaling

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Irgm1 protects hematopoietic stem cells by negative regulation of IFN signaling

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Irgm1 protects hematopoietic stem cells by negative regulation of IFN signaling

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Irgm1 protects hematopoietic stem cells by negative regulation of IFN signaling

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Irgm1 protects hematopoietic stem cells by negative regulation of IFN signaling

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P2093

Dan Liu

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David C Weksberg

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Georgi L Lukov

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Gregory A Taylor

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Jun Qin

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Katherine Y King

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N Tony Eissa

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Nathan C Boles

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Shihua Wu

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Stuart M Chambers

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P2860

Death and resurrection of the human IRGM gene

Autophagy gene variant IRGM -261T contributes to protection from tuberculosis caused by Mycobacterium tuberculosis but not by M. africanum strains

Localisation and mislocalisation of the interferon-inducible immunity-related GTPase, Irgm1 (LRG-47) in mouse cells

Guidelines for the use and interpretation of assays for monitoring autophagy in higher eukaryotes

Histone-like TAFs within the PCAF histone acetylase complex

In vivo analysis of autophagy in response to nutrient starvation using transgenic mice expressing a fluorescent autophagosome marker

Targeting of the GTPase Irgm1 to the phagosomal membrane via PtdIns(3,4)P(2) and PtdIns(3,4,5)P(3) promotes immunity to mycobacteria.

Pathogen-specific loss of host resistance in mice lacking the IFN-gamma-inducible gene IGTP

Molecular signatures of proliferation and quiescence in hematopoietic stem cells

BABELOMICS: a suite of web tools for functional annotation and analysis of groups of genes in high-throughput experiments.

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1525-1533

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10.1182/BLOOD-2011-01-328682

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6

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Margaret A Goodell

Megan T Baldridge

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51184381

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21633090

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3156044

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