Systemic augmentation of alphaB-crystallin provides therapeutic benefit twelve hours post-stroke onset via immune modulation. - Wikidata - awgldk - TriplyDB

Systemic augmentation of alphaB-crystallin provides therapeutic benefit twelve hours post-stroke onset via immune modulation.

Systemic augmentation of alphaB-crystallin provides therapeutic benefit twelve hours post-stroke onset via immune modulation.

http://www.wikidata.org/entity/Q35164861

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Novel Stroke Therapeutics: Unraveling Stroke Pathophysiology and Its Impact on Clinical Treatments Enhanced phasic GABA inhibition during the repair phase of stroke: a novel therapeutic target No quiet surrender: molecular guardians in multiple sclerosis brain Stepwise recruitment of transcellular and paracellular pathways underlies blood-brain barrier breakdown in stroke A New-Age for Biologic Therapies: Long-Term Drug-Free Therapy with BiP?Intraarterial transplantation of human umbilical cord blood mononuclear cells is more efficacious and safer compared with umbilical cord mesenchymal stromal cells in a rodent stroke model.Defective sphingosine 1-phosphate receptor 1 (S1P1) phosphorylation exacerbates TH17-mediated autoimmune neuroinflammation Astrocytic transforming growth factor-beta signaling reduces subacute neuroinflammation after stroke in mice Amyloid fibrils composed of hexameric peptides attenuate neuroinflammation.Protein polymer nanoparticles engineered as chaperones protect against apoptosis in human retinal pigment epithelial cells B-lymphocyte-mediated delayed cognitive impairment following stroke.Therapeutic Intervention in Multiple Sclerosis with Alpha B-Crystallin: A Randomized Controlled Phase IIa Trial.Therapeutic effects of systemic administration of chaperone αB-crystallin associated with binding proinflammatory plasma proteins.Effects of maternal immune activation on gene expression patterns in the fetal brain Proteomic and epigenomic markers of sepsis-induced delirium (SID).Small Heat Shock Protein αB-Crystallin Controls Shape and Adhesion of Glioma and Myoblast Cells in the Absence of Stress Novel roles for α-crystallins in retinal function and disease.Chaperone activity of small heat shock proteins underlies therapeutic efficacy in experimental autoimmune encephalomyelitis.Crystallins and neuroinflammation: The glial side of the story.Induction and phosphorylation of the small heat shock proteins HspB1/Hsp25 and HspB5/αB-crystallin in the rat retina upon optic nerve injury αB-Crystallin regulates expansion of CD11b⁺Gr-1⁺ immature myeloid cells during tumor progression.Antiapoptotic properties of α-crystallin-derived peptide chaperones and characterization of their uptake transporters in human RPE cells.Isolation and Flow Cytometric Analysis of Immune Cells from the Ischemic Mouse Brain Chaperone peptides of α-crystallin inhibit epithelial cell apoptosis, protein insolubilization, and opacification in experimental cataracts A Journey in Science: The Privilege of Exploring the Brain and the Immune System.Effects of sphingosine-1-phosphate receptor 1 phosphorylation in response to FTY720 during neuroinflammation Sinomenine activates astrocytic dopamine D2 receptors and alleviates neuroinflammatory injury via the CRYAB/STAT3 pathway after ischemic stroke in mice.Effects of hyperbaric oxygen preconditioning on cardiac stress markers after simulated diving.Alpha beta-crystallin expression and presentation following infection with murine gammaherpesvirus 68.The protective and therapeutic function of small heat shock proteins in neurological diseases.Impact of diabetes on alpha-crystallins and other heat shock proteins in the eye.Janus faces of amyloid proteins in neuroinflammation.Peroxiredoxin sets the brain on fire after stroke.Therapeutic potential of α-crystallin.Regulation of αA- and αB-crystallins via phosphorylation in cellular homeostasis.Upregulation and phosphorylation of HspB1/Hsp25 and HspB5/αB-crystallin after transient middle cerebral artery occlusion in rats.Identification of highly connected hub genes in the protective response program of human macrophages and microglia activated by alpha B-crystallin.HspB5/αB-crystallin increases dendritic complexity and protects the dendritic arbor during heat shock in cultured rat hippocampal neurons.Replica exchange molecular dynamics simulations provide insight into substrate recognition by small heat shock proteins Activation of Dopamine D2 Receptor Suppresses Neuroinflammation Through αB-Crystalline by Inhibition of NF-κB Nuclear Translocation in Experimental ICH Mice Model.

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Systemic augmentation of alphaB-crystallin provides therapeutic benefit twelve hours post-stroke onset via immune modulation.

http://www.wikidata.org/entity/Q35164861

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2011年の論文

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Systemic augmentation of alpha ...... e onset via immune modulation.

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Systemic augmentation of alpha ...... e onset via immune modulation.

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Proceedings of the National Academy of Sciences of the United States of America

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Ahmet Arac

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Charlene Chen

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Gary K Steinberg

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Gregory W Albers

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Jonathan B Rothbard

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Lawrence Steinman

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Rose M Ko

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Sara E Brownell

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P2860

The influence of the proinflammatory cytokine, osteopontin, on autoimmune demyelinating disease

Differential expression of small heat shock proteins in reactive astrocytes after focal ischemia: possible role of beta-adrenergic receptor

IL-23 is required for neutrophil homeostasis in normal and neutrophilic mice.

Reducing excessive GABA-mediated tonic inhibition promotes functional recovery after stroke.

Inhibitory role for GABA in autoimmune inflammation.

αB crystallin is apically secreted within exosomes by polarized human retinal pigment epithelium and provides neuroprotection to adjacent cells

Calcium-activated RAF/MEK/ERK signaling pathway mediates p53-dependent apoptosis and is abrogated by alpha B-crystallin through inhibition of RAS activation.

The science of stroke: mechanisms in search of treatments.

A new penumbra: transitioning from injury into repair after stroke.

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Marta P Pereira

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