Defective mitophagy in XPA via PARP-1 hyperactivation and NAD(+)/SIRT1 reduction. - Wikidata - awgldk - TriplyDB

Defective mitophagy in XPA via PARP-1 hyperactivation and NAD(+)/SIRT1 reduction.

Defective mitophagy in XPA via PARP-1 hyperactivation and NAD(+)/SIRT1 reduction.

http://www.wikidata.org/entity/Q35165995

about

Emerging therapeutic roles for NAD(+) metabolism in mitochondrial and age-related disorders Mitophagy plays a central role in mitochondrial ageing Connecting the Dots: From DNA Damage and Repair to Aging Sirt1 and the Mitochondria Genome Instability in Development and Aging: Insights from Nucleotide Excision Repair in Humans, Mice, and Worms DNA Damage and Pulmonary Hypertension A high-fat diet and NAD(+) activate Sirt1 to rescue premature aging in cockayne syndrome DNA Damage Response and Autophagy: A Meaningful Partnership New Insights for Oxidative Stress and Diabetes Mellitus Nuclear DNA damage signalling to mitochondria in ageing Mitochondria in the spotlight of aging and idiopathic pulmonary fibrosis Tomatidine enhances lifespan and healthspan in C. elegans through mitophagy induction via the SKN-1/Nrf2 pathway Increased oxidative phosphorylation in response to acute and chronic DNA damage.New facets in the regulation of gene expression by ADP-ribosylation and poly(ADP-ribose) polymerases.Di-(2-ethylhexyl) phthalate inhibits DNA replication leading to hyperPARylation, SIRT1 attenuation, and mitochondrial dysfunction in the testis A new structural insight into XPA-DNA interactions.Methoxyacetic acid suppresses prostate cancer cell growth by inducing growth arrest and apoptosis.DNA polymerase β deficiency leads to neurodegeneration and exacerbates Alzheimer disease phenotypes.Reversal of mitochondrial defects with CSB-dependent serine protease inhibitors in patient cells of the progeroid Cockayne syndrome Aminomethylphosphonic acid and methoxyacetic acid induce apoptosis in prostate cancer cells.Enhanced nucleotide excision repair capacity in lung cancer cells by preconditioning with DNA-damaging agents.XPD localizes in mitochondria and protects the mitochondrial genome from oxidative DNA damage.Impaired mitophagy leads to cigarette smoke stress-induced cellular senescence: implications for chronic obstructive pulmonary disease NAD(+) Metabolism and the Control of Energy Homeostasis: A Balancing Act between Mitochondria and the Nucleus Lack of aprataxin impairs mitochondrial functions via downregulation of the APE1/NRF1/NRF2 pathway.Slow mitochondrial repair of 5'-AMP renders mtDNA susceptible to damage in APTX deficient cells.Ablation of XP-V gene causes adipose tissue senescence and metabolic abnormalities.The Mitochondrial Basis of Aging.Autophagy in Ischemic Livers: A Critical Role of Sirtuin 1/Mitofusin 2 Axis in Autophagy Induction.Suppression of oxidative phosphorylation in mouse embryonic fibroblast cells deficient in apurinic/apyrimidinic endonuclease.Deletion or Inhibition of the Oxygen Sensor PHD1 Protects against Ischemic Stroke via Reprogramming of Neuronal Metabolism.Metabolism and epigenetics.Cockayne syndrome group A and B proteins converge on transcription-linked resolution of non-B DNA.Autophagy requires poly(adp-ribosyl)ation-dependent AMPK nuclear export.DNA polymerase β decrement triggers death of olfactory bulb cells and impairs olfaction in a mouse model of Alzheimer's disease.Protecting the mitochondrial powerhouse.Programming apoptosis and autophagy with novel approaches for diabetes mellitus.The role of DNA base excision repair in brain homeostasis and disease.DNA Damage, DNA Repair, Aging, and Neurodegeneration Genomic and functional integrity of the hematopoietic system requires tolerance of oxidative DNA lesions.

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P2860

Defective mitophagy in XPA via PARP-1 hyperactivation and NAD(+)/SIRT1 reduction.

http://www.wikidata.org/entity/Q35165995

description

2014 nî lūn-bûn

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2014 թուականի Մայիսին հրատարակուած գիտական յօդուած

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2014 թվականի մայիսին հրատարակված գիտական հոդված

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2014年の論文

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2014年論文

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2014年論文

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2014年論文

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2014年論文

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2014年論文

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2014年论文

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name

Defective mitophagy in XPA via PARP-1 hyperactivation and NAD(+)/SIRT1 reduction.

@ast

Defective mitophagy in XPA via PARP-1 hyperactivation and NAD(+)/SIRT1 reduction.

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type

label

Defective mitophagy in XPA via PARP-1 hyperactivation and NAD(+)/SIRT1 reduction.

@ast

Defective mitophagy in XPA via PARP-1 hyperactivation and NAD(+)/SIRT1 reduction.

@en

prefLabel

Defective mitophagy in XPA via PARP-1 hyperactivation and NAD(+)/SIRT1 reduction.

@ast

Defective mitophagy in XPA via PARP-1 hyperactivation and NAD(+)/SIRT1 reduction.

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J.CELL.2014.03.026

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Defective mitophagy in XPA via PARP-1 hyperactivation and NAD(+)/SIRT1 reduction

@en

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Deborah L Croteau

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Henok Kassahun

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Hilde Nilsen

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James R Mitchell

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Tanima SenGupta

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Vilhelm A Bohr

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P2860

Guidelines for the use and interpretation of assays for monitoring autophagy

DNA Damage, Aging, and Cancer

PINK1 and Parkin target Miro for phosphorylation and degradation to arrest mitochondrial motility

Mitochondrial dysfunction in ataxia-telangiectasia

Mitochondria and the autophagy-inflammation-cell death axis in organismal aging

Defective DNA repair and neurodegenerative disease

Resveratrol improves mitochondrial function and protects against metabolic disease by activating SIRT1 and PGC-1alpha

Declining NAD(+) induces a pseudohypoxic state disrupting nuclear-mitochondrial communication during aging

Dissection of the autophagosome maturation process by a novel reporter protein, tandem fluorescent-tagged LC3

Mitochondrial fission, fusion, and stress

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882-896

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157

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Morten Scheibye-Knudsen

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24813611

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