Specific deletion of AMP-activated protein kinase (α1AMPK) in murine oocytes alters junctional protein expression and mitochondrial physiology
about
AMPK: a master energy regulator for gonadal function.AMP-activated protein kinase has diet-dependent and -independent roles in Drosophila oogenesis.Two-cell embryos are more sensitive than blastocysts to AMPK-dependent suppression of anabolism and stemness by commonly used fertility drugs, a diet supplement, and stress.Treatment with AICAR inhibits blastocyst development, trophectoderm differentiation and tight junction formation and function in mice.CoQ10 increases mitochondrial mass and polarization, ATP and Oct4 potency levels, and bovine oocyte MII during IVM while decreasing AMPK activity and oocyte death.Why AMPK agonists not known to be stressors may surprisingly contribute to miscarriage or hinder IVF/ART.
P2860
Specific deletion of AMP-activated protein kinase (α1AMPK) in murine oocytes alters junctional protein expression and mitochondrial physiology
description
2015 nî lūn-bûn
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2015 թուականի Մարտին հրատարակուած գիտական յօդուած
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2015 թվականի մարտին հրատարակված գիտական հոդված
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2015年の論文
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2015年論文
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2015年論文
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2015年論文
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2015年論文
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2015年論文
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2015年论文
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name
Specific deletion of AMP-activ ...... n and mitochondrial physiology
@ast
Specific deletion of AMP-activ ...... n and mitochondrial physiology
@en
type
label
Specific deletion of AMP-activ ...... n and mitochondrial physiology
@ast
Specific deletion of AMP-activ ...... n and mitochondrial physiology
@en
prefLabel
Specific deletion of AMP-activ ...... n and mitochondrial physiology
@ast
Specific deletion of AMP-activ ...... n and mitochondrial physiology
@en
P2093
P2860
P1433
P1476
Specific deletion of AMP-activ ...... n and mitochondrial physiology
@en
P2093
Christelle Ramé
Edith Guibert
Joëlle Dupont
Melanie Faure
Michael J Bertoldo
Pascal Froment
P2860
P304
P356
10.1371/JOURNAL.PONE.0119680
P407
P577
2015-03-13T00:00:00Z