about
Pyruvate dehydrogenase kinase as a novel therapeutic target in oncologyRole of dichloroacetate in the treatment of genetic mitochondrial diseasesDichloroacetate (DCA) as a potential metabolic-targeting therapy for cancerTargeting Cancer Metabolism - Revisiting the Warburg EffectsSepsis-associated hyperlactatemiaNovel therapeutic targets of tumor metabolismSelective Surface PEGylation of UiO-66 Nanoparticles for Enhanced Stability, Cell Uptake, and pH-Responsive Drug Delivery.Mitaplatin, a potent fusion of cisplatin and the orphan drug dichloroacetate.Pyruvate dehydrogenase kinase as a potential therapeutic target for malignant gliomas.Diisopropylamine dichloroacetate, a novel pyruvate dehydrogenase kinase 4 inhibitor, as a potential therapeutic agent for metabolic disorders and multiorgan failure in severe influenzaMitochondrial targeting by dichloroacetate improves outcome following hemorrhagic shock.Metabolic targeting of EGFRvIII/PDK1 axis in temozolomide resistant glioblastoma.On-target inhibition of tumor fermentative glycolysis as visualized by hyperpolarized pyruvate.Dichloroacetate induces apoptosis and cell-cycle arrest in colorectal cancer cellsSilencing gastrin-releasing peptide receptor suppresses key regulators of aerobic glycolysis in neuroblastoma cellsRole of SLC5A8, a plasma membrane transporter and a tumor suppressor, in the antitumor activity of dichloroacetate.Dichloroacetate blocks aerobic glycolytic adaptation to attenuated measles virus and promotes viral replication leading to enhanced oncolysis in glioblastoma.Dichloroacetate restores drug sensitivity in paclitaxel-resistant cells by inducing citric acid accumulation.DCA promotes progression of neuroblastoma tumors in nude mice.Phase 1 trial of dichloroacetate (DCA) in adults with recurrent malignant brain tumors.IL-1β irreversibly inhibits tenogenic differentiation and alters metabolism in injured tendon-derived progenitor cells in vitro.Metabolic targeting of hypoxia and HIF1 in solid tumors can enhance cytotoxic chemotherapy.Pyruvate in the correction of intracellular acidosis: a metabolic basis as a novel superior buffer.Lactate dehydrogenase-A inhibition induces human glioblastoma multiforme stem cell differentiation and deathVolumetric spiral chemical shift imaging of hyperpolarized [2-(13) c]pyruvate in a rat c6 glioma model.Pulmonary arterial hypertension: new insights and new hope.Activating oxidative phosphorylation by a pyruvate dehydrogenase kinase inhibitor overcomes sorafenib resistance of hepatocellular carcinoma.Metabolic response of glioma to dichloroacetate measured in vivo by hyperpolarized (13)C magnetic resonance spectroscopic imagingMetabolic disorder, inflammation, and deregulated molecular pathways converging in pancreatic cancer development: implications for new therapeutic strategies.Multi-modality imaging to assess metabolic response to dichloroacetate treatment in tumor models.ASCT2 (SLC1A5) is an EGFR-associated protein that can be co-targeted by cetuximab to sensitize cancer cells to ROS-induced apoptosis.Transforming Growth Factor β Mediates Drug Resistance by Regulating the Expression of Pyruvate Dehydrogenase Kinase 4 in Colorectal Cancer.Pharmacogenetic considerations with dichloroacetate dosing.Epigenetics, inflammation and metabolism in right heart failure associated with pulmonary hypertension.Cytometric assessment of DNA damage by exogenous and endogenous oxidants reports aging-related processes.Acidic pH Is a Metabolic Switch for 2-Hydroxyglutarate Generation and Signaling.Reversal of the glycolytic phenotype of primary effusion lymphoma cells by combined targeting of cellular metabolism and PI3K/Akt/ mTOR signaling.Comparison of spheroids formed by rat glioma stem cells and neural stem cells reveals differences in glucose metabolism and promising therapeutic applications.Current Developments in Pt(IV) Prodrugs Conjugated with Bioactive LigandsDichloroacetate, an inhibitor of pyruvate dehydrogenase kinases, inhibits platelet aggregation and arterial thrombosis
P2860
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P2860
description
2003 nî lūn-bûn
@nan
2003 թուականի Յուլիսին հրատարակուած գիտական յօդուած
@hyw
2003 թվականի հուլիսին հրատարակված գիտական հոդված
@hy
2003年の論文
@ja
2003年論文
@yue
2003年論文
@zh-hant
2003年論文
@zh-hk
2003年論文
@zh-mo
2003年論文
@zh-tw
2003年论文
@wuu
name
Efficacy of dichloroacetate as a lactate-lowering drug.
@ast
Efficacy of dichloroacetate as a lactate-lowering drug.
@en
type
label
Efficacy of dichloroacetate as a lactate-lowering drug.
@ast
Efficacy of dichloroacetate as a lactate-lowering drug.
@en
prefLabel
Efficacy of dichloroacetate as a lactate-lowering drug.
@ast
Efficacy of dichloroacetate as a lactate-lowering drug.
@en
P2093
P1476
Efficacy of dichloroacetate as a lactate-lowering drug.
@en
P2093
Alan D Hutson
Nelamangala V Nagaraja
Peter W Stacpoole
P304
P356
10.1177/0091270003043007001
P577
2003-07-01T00:00:00Z