Lysyl hydroxylase 2 induces a collagen cross-link switch in tumor stroma
about
Hypoxia and TGF-β1 induced PLOD2 expression improve the migration and invasion of cervical cancer cells by promoting epithelial-to-mesenchymal transition (EMT) and focal adhesion formationThe ErbB2ΔEx16 splice variant is a major oncogenic driver in breast cancer that promotes a pro-metastatic tumor microenvironment.Cyclophilin-B Modulates Collagen Cross-linking by Differentially Affecting Lysine Hydroxylation in the Helical and Telopeptidyl Domains of Tendon Type I Collagen.Disentangling mechanisms involved in collagen pyridinoline cross-linking: The immunophilin FKBP65 is critical for dimerization of lysyl hydroxylase 2P-selectin-mediated LOX expression promotes insulinoma growth in Rip1-Tag2 mice by increasing tissue stiffnessFKBP65-dependent peptidyl-prolyl isomerase activity potentiates the lysyl hydroxylase 2-driven collagen cross-link switch.Lysyl Hydroxylase 2 Is Secreted by Tumor Cells and Can Modify Collagen in the Extracellular Space.Cancer-Associated Fibroblasts Induce a Collagen Cross-link Switch in Tumor Stroma.Osteolytic and mixed cancer metastasis modulates collagen and mineral parameters within rat vertebral bone matrix.PLOD2 regulated by transcription factor FOXA1 promotes metastasis in NSCLC.A Unique TGFB1-Driven Genomic Program Links Astrocytosis, Low-Grade Inflammation and Partial Demyelination in Spinal Cord Periplaques from Progressive Multiple Sclerosis Patients.The fibrotic tumor stroma.Pro-metastatic collagen lysyl hydroxylase dimer assemblies stabilized by Fe2+-binding.Mechanical Loading Stimulates Expression of Collagen Cross-Linking Associated Enzymes in Periodontal Ligament.Overexpression of PLOD3 promotes tumor progression and poor prognosis in gliomas.Roles of PLODs in Collagen Synthesis and Cancer Progression.Development of a Novel 3D Tumor-tissue Invasion Model for High-throughput, High-content Phenotypic Drug ScreeningExtracellular matrix with defective collagen cross-linking affects the differentiation of bone cellsDiagnostic role of circulating extracellular matrix-related proteins in non-small cell lung cancerLysyl hydroxylases are transcription targets for GATA3 driving lung cancer cell metastasisPLOD3 promotes lung metastasis via regulation of STAT3The evolving relationship of wound healing and tumor stroma
P2860
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P2860
Lysyl hydroxylase 2 induces a collagen cross-link switch in tumor stroma
description
2015 nî lūn-bûn
@nan
2015 թուականի Փետրուարին հրատարակուած գիտական յօդուած
@hyw
2015 թվականի փետրվարին հրատարակված գիտական հոդված
@hy
2015年の論文
@ja
2015年論文
@yue
2015年論文
@zh-hant
2015年論文
@zh-hk
2015年論文
@zh-mo
2015年論文
@zh-tw
2015年论文
@wuu
name
Lysyl hydroxylase 2 induces a collagen cross-link switch in tumor stroma
@ast
Lysyl hydroxylase 2 induces a collagen cross-link switch in tumor stroma
@en
type
label
Lysyl hydroxylase 2 induces a collagen cross-link switch in tumor stroma
@ast
Lysyl hydroxylase 2 induces a collagen cross-link switch in tumor stroma
@en
prefLabel
Lysyl hydroxylase 2 induces a collagen cross-link switch in tumor stroma
@ast
Lysyl hydroxylase 2 induces a collagen cross-link switch in tumor stroma
@en
P2093
P2860
P50
P356
P1476
Lysyl hydroxylase 2 induces a collagen cross-link switch in tumor stroma
@en
P2093
Alan R Burns
Carmen Behrens
Chad J Creighton
Daniela Pankova
Debananda Pati
Elisabeth D Martinez
Ignacio I Wistuba
Jaime Rodriguez
Johannah Sanchez-Adams
P2860
P304
P356
10.1172/JCI74725
P407
P577
2015-02-09T00:00:00Z