Translocation channel gating kinetics balances protein translocation efficiency with signal sequence recognition fidelity
about
BiP-mediated closing of the Sec61 channel limits Ca2+ leakage from the ERERAD and protein import defects in a sec61 mutant lacking ER-lumenal loop 7.BiP clustering facilitates protein folding in the endoplasmic reticulumStructural and functional profiling of the lateral gate of the Sec61 transloconProteasome 19S RP binding to the Sec61 channel plays a key role in ERAD.Aberrant substrate engagement of the ER translocon triggers degradation by the Hrd1 ubiquitin ligase.Direct simulation of early-stage Sec-facilitated protein translocationA gating motif in the translocation channel sets the hydrophobicity threshold for signal sequence function.Protein translocation across the rough endoplasmic reticulum.Understanding integration of α-helical membrane proteins: the next stepsAn allosteric Sec61 inhibitor traps nascent transmembrane helices at the lateral gate.A signal sequence suppressor mutant that stabilizes an assembled state of the twin arginine translocase.
P2860
Q24293288-4D644339-F9BD-48A0-AB96-5A524361DE48Q27931054-D6AAA884-52F4-4A44-9D1C-21B50BE1CE67Q31171777-6C0F5C10-2A02-4E18-BFE8-F6C7070B0B6AQ34076055-538A2430-A1ED-4721-993E-4BAFD462A7BDQ35556723-4B250229-5655-49AD-A174-3433069A3D88Q36027390-71DA61CF-17F4-4500-9C69-73F86E1EFC2BQ36200511-6037A6A1-1C34-4BB2-9E31-725FF0E112A1Q36455908-5D775929-BAFD-4BFD-B021-3638B4162163Q36555178-721326A5-4041-4A8B-9225-1D9D1DF33E48Q36570393-A61BC61F-D2FB-4CE6-AAF8-449B537B16ABQ37552363-39271CAF-96A6-4526-8D15-50C79C069AE2Q37696002-518BCA63-B031-486A-870F-7656F32F3367
P2860
Translocation channel gating kinetics balances protein translocation efficiency with signal sequence recognition fidelity
description
2011 nî lūn-bûn
@nan
2011 թուականի Յուլիսին հրատարակուած գիտական յօդուած
@hyw
2011 թվականի հուլիսին հրատարակված գիտական հոդված
@hy
2011年の論文
@ja
2011年論文
@yue
2011年論文
@zh-hant
2011年論文
@zh-hk
2011年論文
@zh-mo
2011年論文
@zh-tw
2011年论文
@wuu
name
Translocation channel gating k ...... sequence recognition fidelity
@ast
Translocation channel gating k ...... sequence recognition fidelity
@en
type
label
Translocation channel gating k ...... sequence recognition fidelity
@ast
Translocation channel gating k ...... sequence recognition fidelity
@en
prefLabel
Translocation channel gating k ...... sequence recognition fidelity
@ast
Translocation channel gating k ...... sequence recognition fidelity
@en
P2093
P2860
P356
P1476
Translocation channel gating k ...... sequence recognition fidelity
@en
P2093
Elisabet C Mandon
Reid Gilmore
Steven F Trueman
P2860
P304
P356
10.1091/MBC.E11-01-0070
P577
2011-07-07T00:00:00Z