Human cancer-associated mutations in the Aα subunit of protein phosphatase 2A increase lung cancer incidence in Aα knock-in and knockout mice.
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The broken "Off" switch in cancer signaling: PP2A as a regulator of tumorigenesis, drug resistance, and immune surveillanceThe biogenesis of active protein phosphatase 2A holoenzymes: a tightly regulated process creating phosphatase specificityCircumventing embryonic lethality with Lcmt1 deficiency: generation of hypomorphic Lcmt1 mice with reduced protein phosphatase 2A methyltransferase expression and defects in insulin signalingThe Basic Biology of PP2A in Hematologic Cells and MalignanciesPP2A: The Wolf in Sheep's Clothing?Protein Ser/Thr phosphatases--the ugly ducklings of cell signalling.A protein array screen for Kaposi's sarcoma-associated herpesvirus LANA interactors links LANA to TIP60, PP2A activity, and telomere shortening.Phosphatase: PP2A structural importance, regulation and its aberrant expression in cancer.Inhibition of protein phosphatase 2A with a small molecule LB100 radiosensitizes nasopharyngeal carcinoma xenografts by inducing mitotic catastrophe and blocking DNA damage repair.Ligand-directed targeting of lymphatic vessels uncovers mechanistic insights in melanoma metastasisProtein Phosphatase 2A Inhibition with LB100 Enhances Radiation-Induced Mitotic Catastrophe and Tumor Growth Delay in Glioblastoma.Mouse model for probing tumor suppressor activity of protein phosphatase 2A in diverse signaling pathways.Overexpression of PP2A inhibitor SET oncoprotein is associated with tumor progression and poor prognosis in human non-small cell lung cancer.Protein Phosphatase 6 Protects Prophase I-Arrested Oocytes by Safeguarding Genomic IntegrityPP2A Counterbalances Phosphorylation of pRB and Mitotic Proteins by Multiple CDKs: Potential Implications for PP2A Disruption in CancerPhosphatase PP2A is requisite for the function of regulatory T cells.PR55α Subunit of Protein Phosphatase 2A Supports the Tumorigenic and Metastatic Potential of Pancreatic Cancer Cells by Sustaining Hyperactive Oncogenic Signaling.Impaired expression of protein phosphatase 2A subunits enhances metastatic potential of human prostate cancer cells through activation of AKT pathway.Microtubule attachment and spindle assembly checkpoint signalling at the kinetochore.Protein phosphatase 2A: a target for anticancer therapy.Protein phosphatases PP2A, PP4 and PP6: mediators and regulators in development and responses to environmental cues.All roads lead to PP2A: exploiting the therapeutic potential of this phosphatase.Deregulation of the protein phosphatase 2A, PP2A in cancer: complexity and therapeutic options.Activation of protein phosphatase 2A in FLT3+ acute myeloid leukemia cells enhances the cytotoxicity of FLT3 tyrosine kinase inhibitors.The Neurospora crassa PP2A Regulatory Subunits RGB1 and B56 Are Required for Proper Growth and Development and Interact with the NDR Kinase COT1.Deregulation of the phosphatase, PP2A is a common event in breast cancer, predicting sensitivity to FTY720.Dephosphorylation by protein phosphatase 2A regulates visual pigment regeneration and the dark adaptation of mammalian photoreceptors.Therapeutic Targeting of PP2A.Functional importance of PP2A regulatory subunit loss in breast cancer.CIP2A expression predicts recurrences of tamoxifen-treated breast cancer.Loss of protein phosphatase 2A regulatory subunit B56δ promotes spontaneous tumorigenesis in vivo.Developmental and light regulation of tumor suppressor protein PP2A in the retina.Targeted Therapies in Type II Endometrial Cancers: Too Little, but Not Too Late
P2860
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P2860
Human cancer-associated mutations in the Aα subunit of protein phosphatase 2A increase lung cancer incidence in Aα knock-in and knockout mice.
description
2011 nî lūn-bûn
@nan
2011 թուականի Յուլիսին հրատարակուած գիտական յօդուած
@hyw
2011 թվականի հուլիսին հրատարակված գիտական հոդված
@hy
2011年の論文
@ja
2011年論文
@yue
2011年論文
@zh-hant
2011年論文
@zh-hk
2011年論文
@zh-mo
2011年論文
@zh-tw
2011年论文
@wuu
name
Human cancer-associated mutati ...... Aα knock-in and knockout mice.
@ast
Human cancer-associated mutati ...... Aα knock-in and knockout mice.
@en
type
label
Human cancer-associated mutati ...... Aα knock-in and knockout mice.
@ast
Human cancer-associated mutati ...... Aα knock-in and knockout mice.
@en
prefLabel
Human cancer-associated mutati ...... Aα knock-in and knockout mice.
@ast
Human cancer-associated mutati ...... Aα knock-in and knockout mice.
@en
P2093
P2860
P356
P1476
Human cancer-associated mutati ...... Aα knock-in and knockout mice.
@en
P2093
Gernot Walter
Jennifer Ruiz
Ralf Ruediger
P2860
P304
P356
10.1128/MCB.05744-11
P407
P577
2011-07-26T00:00:00Z