The intrinsic pKa-values of functional groups in enzymes: improper deductions from the pH-dependence of steady-state parameters.
about
Inactivation of the RTEM-1 cysteine beta-lactamase by iodoacetate. The nature of active-site functional groups and comparisons with the native enzymeOrigin of the different pH activity profile in two homologous ketosteroid isomerasesDivergence of Catalytic Mechanism within a Glycosidase Family Provides Insight into Evolution of Carbohydrate Metabolism by Human Gut FloraMechanistic Characterization of the Tetraacyldisaccharide-1-phosphate 4′-Kinase LpxK Involved in Lipid A BiosynthesisProbing the role of highly conserved residues in triosephosphate isomerase--analysis of site specific mutants at positions 64 and 75 in the Plasmodial enzymeIn crystals of complexes of streptavidin with peptide ligands containing the HPQ sequence the pKa of the peptide histidine is less than 3.0Interaction of the lacZ beta-galactosidase of Escherichia coli with some beta-D-galactopyranoside competitive inhibitorsSubstrate-derived two-protonic-state electrophiles as sensitive kinetic specificity probes for cysteine proteinases. Activation of 2-pyridyl disulphides by hydrogen-bondingThermodynamic linkage between the binding of protons and inhibitors to HIV-1 protease.Rapid assembly of a library of lipophilic iminosugars via the thiol-ene reaction yields promising pharmacological chaperones for the treatment of Gaucher diseaseDevelopment of inhibitors as research tools for carbohydrate-processing enzymes.Quantitative reactivity profiling predicts functional cysteines in proteomes.Evidence for proton transfer in the rate-limiting step of a fast-cleaving Varkud satellite ribozyme.Carboxypeptidase A mechanisms.Tautomerism, acid-base equilibria, and H-bonding of the six histidines in subtilisin BPN' by NMREffects of pH on the structure and function of carboxypeptidase A: crystallographic studies.Glycosidase inhibition: assessing mimicry of the transition state.Target identification with quantitative activity based protein profiling (ABPP).Benzofuroxan as a thiol-specific reactivity probe. Kinetics of its reactions with papain, ficin, bromelain and low-molecular-weight thiols.The pH-dependence of second-order rate constants of enzyme modification may provide free-reactant pKa valuesSpectrophotometric studies on the interaction between triose phosphate isomerase and inhibitors.Mechanism of Human Nucleocytoplasmic Hexosaminidase D.Sulphate-activated phosphorylase b: the pH-dependence of catalytic activitypH-activity curves for enzyme-catalysed reactions in which the hydron is a product or reactant.The pKa of the catalytic histidine residue of chloramphenicol acetyltransferase.Structural investigation of heteroyohimbine alkaloid synthesis reveals active site elements that control stereoselectivity.The EcoRI restriction endonuclease with bacteriophage lambda DNA. Kinetic studies.Kinetic and mechanistic studies of a cell cycle protein phosphatase Cdc14.pH-dependent random coil (1)H, (13)C, and (15)N chemical shifts of the ionizable amino acids: a guide for protein pK a measurements.High effective cytosolic H+ buffering in mouse cortical astrocytes attributable to fast bicarbonate transport.Catalytic mechanism of the tryptophan synthase alpha(2)beta(2) complex. Effects of pH, isotopic substitution, and allosteric ligands.Origin of the ‘inactivation’ of ribonuclease A at low salt concentration
P2860
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P2860
The intrinsic pKa-values of functional groups in enzymes: improper deductions from the pH-dependence of steady-state parameters.
description
1976 nî lūn-bûn
@nan
1976 թուականի Նոյեմբերին հրատարակուած գիտական յօդուած
@hyw
1976 թվականի նոյեմբերին հրատարակված գիտական հոդված
@hy
1976年の論文
@ja
1976年論文
@yue
1976年論文
@zh-hant
1976年論文
@zh-hk
1976年論文
@zh-mo
1976年論文
@zh-tw
1976年论文
@wuu
name
The intrinsic pKa-values of fu ...... ce of steady-state parameters.
@ast
The intrinsic pKa-values of fu ...... ce of steady-state parameters.
@en
type
label
The intrinsic pKa-values of fu ...... ce of steady-state parameters.
@ast
The intrinsic pKa-values of fu ...... ce of steady-state parameters.
@en
prefLabel
The intrinsic pKa-values of fu ...... ce of steady-state parameters.
@ast
The intrinsic pKa-values of fu ...... ce of steady-state parameters.
@en
P2860
P1476
The intrinsic pKa-values of fu ...... ce of steady-state parameters.
@en
P2093
Knowles JR
P2860
P304
P356
10.3109/10409237609105457
P577
1976-11-01T00:00:00Z