Functional interactions of Prp8 with both splice sites at the spliceosomal catalytic center. - Wikidata - awgldk - TriplyDB

Functional interactions of Prp8 with both splice sites at the spliceosomal catalytic center.

Functional interactions of Prp8 with both splice sites at the spliceosomal catalytic center.

http://www.wikidata.org/entity/Q35203137

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The human U5 snRNP 52K protein (CD2BP2) interacts with U5-102K (hPrp6), a U4/U6.U5 tri-snRNP bridging protein, but dissociates upon tri-snRNP formation.The 65 and 110 kDa SR-related proteins of the U4/U6.U5 tri-snRNP are essential for the assembly of mature spliceosomes A novel U2 and U11/U12 snRNP protein that associates with the pre-mRNA branch site.Prp8 protein: at the heart of the spliceosome The network of protein-protein interactions within the human U4/U6.U5 tri-snRNP An upstream AG determines whether a downstream AG is selected during catalytic step II of splicing The spliceosome deposits multiple proteins 20-24 nucleotides upstream of mRNA exon-exon junctions Pre-mRNA splicing alters mRNP composition: evidence for stable association of proteins at exon-exon junctions Extended base pair complementarity between U1 snRNA and the 5' splice site does not inhibit splicing in higher eukaryotes, but rather increases 5' splice site recognition The architecture of the spliceosomal U4/U6.U5 tri-snRNP.Crystal structure of the functional domain of the splicing factor Prp18 Crystal structure of the -finger domain of Prp8 reveals analogy to ribosomal proteins Structure and function of an RNase H domain at the heart of the spliceosome Structural basis for dual roles of Aar2p in U5 snRNP assembly A conformational switch in PRP8 mediates metal ion coordination that promotes pre-mRNA exon ligation Evidence for a role of Sky1p-mediated phosphorylation in 3' splice site recognition involving both Prp8 and Prp17/Slu4.The Isy1p component of the NineTeen complex interacts with the ATPase Prp16p to regulate the fidelity of pre-mRNA splicing.Functional interactions between Prp8, Prp18, Slu7, and U5 snRNA during the second step of pre-mRNA splicing.The yeast U5 snRNP coisolated with the U1 snRNP has an unexpected protein composition and includes the splicing factor Aar2p Splicing proofreading at 5' splice sites by ATPase Prp28p.Prp8 retinitis pigmentosa mutants cause defects in the transition between the catalytic steps of splicing.CEF1/CDC5 alleles modulate transitions between catalytic conformations of the spliceosome.Central region of the human splicing factor Hprp3p interacts with Hprp4p ATP-dependent interaction of yeast U5 snRNA loop 1 with the 5' splice site.A ribozyme selected from variants of U6 snRNA promotes 2',5'-branch formation The 100-kda U5 snRNP protein (hPrp28p) contacts the 5' splice site through its ATPase site RNA structure analysis of human spliceosomes reveals a compact 3D arrangement of snRNAs at the catalytic core.Defining a 5' splice site by functional selection in the presence and absence of U1 snRNA 5' end.A general approach for identification of RNA-protein cross-linking sites within native human spliceosomal small nuclear ribonucleoproteins (snRNPs). Analysis of RNA-protein contacts in native U1 and U4/U6.U5 snRNPs.From the ribosome to the spliceosome and back again.SF3b1 mutations associated with myelodysplastic syndromes alter the fidelity of branchsite selection in yeast Interaction of the yeast DExH-box RNA helicase prp22p with the 3' splice site during the second step of nuclear pre-mRNA splicing Spliceosomal introns in the deep-branching eukaryote Trichomonas vaginalis Distinct domains of splicing factor Prp8 mediate different aspects of spliceosome activation Proximity of the invariant loop of U5 snRNA to the second intron residue during pre-mRNA splicing.trans and cis splicing in trypanosomatids: mechanism, factors, and regulation.A tertiary interaction detected in a human U2-U6 snRNA complex assembled in vitro resembles a genetically proven interaction in yeast.Splicing enhancement in the yeast rp51b intron.Identification of a U2/U6 helix la mutant that influences 3' splice site selection during nuclear pre-mRNA splicing.Genetic interactions between the 5' and 3' splice site consensus sequences and U6 snRNA during the second catalytic step of pre-mRNA splicing.

P2860

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P2860

Functional interactions of Prp8 with both splice sites at the spliceosomal catalytic center.

http://www.wikidata.org/entity/Q35203137

description

1999 nî lūn-bûn

@nan

1999 թուականի Օգոստոսին հրատարակուած գիտական յօդուած

@hyw

1999 թվականի օգոստոսին հրատարակված գիտական հոդված

@hy

1999年の論文

@ja

1999年論文

@yue

1999年論文

@zh-hant

1999年論文

@zh-hk

1999年論文

@zh-mo

1999年論文

@zh-tw

1999年论文

@wuu

name

Functional interactions of Prp ...... spliceosomal catalytic center.

@ast

Functional interactions of Prp ...... spliceosomal catalytic center.

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type

label

Functional interactions of Prp ...... spliceosomal catalytic center.

@ast

Functional interactions of Prp ...... spliceosomal catalytic center.

@en

prefLabel

Functional interactions of Prp ...... spliceosomal catalytic center.

@ast

Functional interactions of Prp ...... spliceosomal catalytic center.

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P1433

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P2860

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P1433

Genes & Development

P1476

Functional interactions of Prp ...... spliceosomal catalytic center.

@en

P2093

J L Reyes

http://www.w3.org/2001/XMLSchema#string

M M Konarska

http://www.w3.org/2001/XMLSchema#string

M Siatecka

http://www.w3.org/2001/XMLSchema#string

P2860

The human U5-220kD protein (hPrp8) forms a stable RNA-free complex with several U5-specific proteins, including an RNA unwindase, a homologue of ribosomal elongation factor EF-2, and a novel WD-40 protein

Evidence that U5 snRNP recognizes the 3' splice site for catalytic step II in mammals

The canonical GU dinucleotide at the 5' splice site is recognized by p220 of the U5 snRNP within the spliceosome

The C-terminal region of hPrp8 interacts with the conserved GU dinucleotide at the 5' splice site

The human Prp8 protein is a component of both U2- and U12-dependent spliceosomes

A cold-sensitive mRNA splicing mutant is a member of the RNA helicase gene family.

Cross-intron bridging interactions in the yeast commitment complex are conserved in mammals

Identification of Prp40, a novel essential yeast splicing factor associated with the U1 small nuclear ribonucleoprotein particle

Getting started with yeast

Terminal intron dinucleotide sequences do not distinguish between U2- and U12-dependent introns

P304

1983-1993

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P31

scholarly article

P356

10.1101/GAD.13.15.1983

http://www.w3.org/2001/XMLSchema#string

P433

15

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P478

13

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P577

1999-08-01T00:00:00Z

http://www.w3.org/2001/XMLSchema#dateTime

P5875

12854418

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P698

10444596

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P921

P932

316927

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