Efficacy of synaptic inhibition depends on multiple, dynamically interacting mechanisms implicated in chloride homeostasis.
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Role of the neuronal K-Cl co-transporter KCC2 in inhibitory and excitatory neurotransmissionIon dynamics during seizuresSerotonergic modulation of post-synaptic inhibition and locomotor alternating pattern in the spinal cordInhibitory synaptic plasticity: spike timing-dependence and putative network function.Spines slow down dendritic chloride diffusion and affect short-term ionic plasticity of GABAergic inhibition.Extended two-photon microscopy in live samples with Bessel beams: steadier focus, faster volume scans, and simpler stereoscopic imagingDiminished KCC2 confounds synapse specificity of LTP during senescenceChloride extrusion enhancers as novel therapeutics for neurological diseasesCation-chloride cotransporters in neuronal development, plasticity and diseaseInterplay of intrinsic and synaptic conductances in the generation of high-frequency oscillations in interneuronal networks with irregular spiking.Engagement of the GABA to KCC2 signaling pathway contributes to the analgesic effects of A3AR agonists in neuropathic painMicroglia disrupt mesolimbic reward circuitry in chronic pain.Spatial Intensity Distribution Analysis Reveals Abnormal Oligomerization of Proteins in Single CellsModulation of spinal GABAergic analgesia by inhibition of chloride extrusion capacity in mice.Improved Simulation of Electrodiffusion in the Node of Ranvier by Mesh Adaptation.Combined Changes in Chloride Regulation and Neuronal Excitability Enable Primary Afferent Depolarization to Elicit Spiking without Compromising its Inhibitory EffectsActivation of 5-HT2A receptors upregulates the function of the neuronal K-Cl cotransporter KCC2.Neuroimmune Regulation of GABAergic Neurons Within the Ventral Tegmental Area During Withdrawal from Chronic Morphine.TRPM7 is regulated by halides through its kinase domainDisrupted Cl(-) homeostasis contributes to reductions in the inhibitory efficacy of diazepam during hyperexcited statesMorphine hyperalgesia gated through microglia-mediated disruption of neuronal Cl⁻ homeostasis.Impairment of GABA transporter GAT-1 terminates cortical recurrent network activity via enhanced phasic inhibition.Inhibition of carbonic anhydrase augments GABAA receptor-mediated analgesia via a spinal mechanism of action.Microglia control neuronal network excitability via BDNF signalling.Inhibitory regulation of the pain gate and how its failure causes pathological pain.Enhancing KCC2 function counteracts morphine-induced hyperalgesia.Chloride Dysregulation, Seizures, and Cerebral Edema: A Relationship with Therapeutic Potential.Inter-Synaptic Lateral Diffusion of GABAA Receptors Shapes Inhibitory Synaptic Currents.Short-term ionic plasticity at GABAergic synapses.Mild KCC2 Hypofunction Causes Inconspicuous Chloride Dysregulation that Degrades Neural Coding.Genetically encoded proton sensors reveal activity-dependent pH changes in neurons.Pyramidal cells accumulate chloride at seizure onset.Contribution of Resting Conductance, GABAA-Receptor Mediated Miniature Synaptic Currents and Neurosteroid to Chloride Homeostasis in Central Neurons.Diazepam effect during early neonatal development correlates with neuronal Cl(.).Transient increase in neuronal chloride concentration by neuroactive aminoacids released from glioma cells.Computational model of interictal discharges triggered by interneurons.Neuroligin 2 regulates spinal GABAergic plasticity in hyperalgesic priming, a model of the transition from acute to chronic painLocal impermeant anions establish the neuronal chloride concentrationModeling the effects of neuronal morphology on dendritic chloride diffusion and GABAergic inhibition.GABAA receptor dependent synaptic inhibition rapidly tunes KCC2 activity via the Cl--sensitive WNK1 kinase.
P2860
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P2860
Efficacy of synaptic inhibition depends on multiple, dynamically interacting mechanisms implicated in chloride homeostasis.
description
2011 nî lūn-bûn
@nan
2011 թուականի Սեպտեմբերին հրատարակուած գիտական յօդուած
@hyw
2011 թվականի սեպտեմբերին հրատարակված գիտական հոդված
@hy
2011年の論文
@ja
2011年論文
@yue
2011年論文
@zh-hant
2011年論文
@zh-hk
2011年論文
@zh-mo
2011年論文
@zh-tw
2011年论文
@wuu
name
Efficacy of synaptic inhibitio ...... cated in chloride homeostasis.
@ast
Efficacy of synaptic inhibitio ...... cated in chloride homeostasis.
@en
type
label
Efficacy of synaptic inhibitio ...... cated in chloride homeostasis.
@ast
Efficacy of synaptic inhibitio ...... cated in chloride homeostasis.
@en
prefLabel
Efficacy of synaptic inhibitio ...... cated in chloride homeostasis.
@ast
Efficacy of synaptic inhibitio ...... cated in chloride homeostasis.
@en
P2093
P2860
P1476
Efficacy of synaptic inhibitio ...... cated in chloride homeostasis.
@en
P2093
Antoine G Godin
Helmut Kröger
Nicolas Doyon
Steven A Prescott
P2860
P304
P356
10.1371/JOURNAL.PCBI.1002149
P577
2011-09-08T00:00:00Z