Synthesis and biological evaluations of putative metabolically stable analogs of VN/124-1 (TOK-001): head to head anti-tumor efficacy evaluation of VN/124-1 (TOK-001) and abiraterone in LAPC-4 human prostate cancer xenograft model.
about
CYP17 inhibitors in prostate cancer: latest evidence and clinical potentialAndrogen synthesis inhibitors in the treatment of castration-resistant prostate cancer.Targeting androgen receptor action for prostate cancer treatment: does the post-receptor level provide novel opportunities?CYP17 inhibitors--abiraterone, C17,20-lyase inhibitors and multi-targeting agents.In silico discovery of androgen receptor antagonists with activity in castration resistant prostate cancerThe hunt for a selective 17,20 lyase inhibitor; learning lessons from nature.Comparisons of Prostate Cancer Inhibitors Abiraterone and TOK-001 Binding with CYP17A1 through Molecular DynamicsGaleterone and VNPT55 induce proteasomal degradation of AR/AR-V7, induce significant apoptosis via cytochrome c release and suppress growth of castration resistant prostate cancer xenografts in vivo.Novel therapies for the treatment of advanced prostate cancer.Molecular pathways: Inhibiting steroid biosynthesis in prostate cancer.A new simple and high-yield synthesis of 5α-dihydrotestosterone (DHT), a potent androgen receptor agonist.Ligand-independent and tissue-selective androgen receptor inhibition by pyrvinium.Castration-resistant prostate cancer: many treatments, many options, many challenges ahead.Anticancer steroids: linking natural and semi-synthetic compounds.The evolution of prostate cancer therapy: targeting the androgen receptorSystematic structure modifications of multitarget prostate cancer drug candidate galeterone to produce novel androgen receptor down-regulating agents as an approach to treatment of advanced prostate cancer.Androgen receptor variation affects prostate cancer progression and drug resistance.Galeterone prevents androgen receptor binding to chromatin and enhances degradation of mutant androgen receptor.Identification of Novel Steroidal Androgen Receptor Degrading Agents Inspired by Galeterone 3β-Imidazole CarbamateNovel galeterone analogs act independently of AR and AR-V7 for the activation of the unfolded protein response and induction of apoptosis in the CWR22Rv1 prostate cancer cell model.Steroidogenic Metabolism of Galeterone Reveals a Diversity of Biochemical Activities.The novel anti-androgen candidate galeterone targets deubiquitinating enzymes, USP12 and USP46, to control prostate cancer growth and survival.Structural and Functional Evaluation of Clinically Relevant Inhibitors of Steroidogenic Cytochrome P450 17A1.
P2860
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P2860
Synthesis and biological evaluations of putative metabolically stable analogs of VN/124-1 (TOK-001): head to head anti-tumor efficacy evaluation of VN/124-1 (TOK-001) and abiraterone in LAPC-4 human prostate cancer xenograft model.
description
2011 nî lūn-bûn
@nan
2011 թուականի Յունիսին հրատարակուած գիտական յօդուած
@hyw
2011 թվականի հունիսին հրատարակված գիտական հոդված
@hy
2011年の論文
@ja
2011年論文
@yue
2011年論文
@zh-hant
2011年論文
@zh-hk
2011年論文
@zh-mo
2011年論文
@zh-tw
2011年论文
@wuu
name
Synthesis and biological evalu ...... ostate cancer xenograft model.
@ast
Synthesis and biological evalu ...... ostate cancer xenograft model.
@en
type
label
Synthesis and biological evalu ...... ostate cancer xenograft model.
@ast
Synthesis and biological evalu ...... ostate cancer xenograft model.
@en
prefLabel
Synthesis and biological evalu ...... ostate cancer xenograft model.
@ast
Synthesis and biological evalu ...... ostate cancer xenograft model.
@en
P2093
P2860
P1433
P1476
Synthesis and biological evalu ...... ostate cancer xenograft model.
@en
P2093
Abhijit M Godbole
Angela M H Brodie
Lalji K Gediya
Puranik Purushottamachar
Robert D Bruno
Tadas S Vasaitis
Vincent C O Njar
Zeynep Ates-Alagoz
P2860
P304
P356
10.1016/J.STEROIDS.2011.06.002
P577
2011-06-24T00:00:00Z