CDK inhibitors p18(INK4c) and p27(Kip1) mediate two separate pathways to collaboratively suppress pituitary tumorigenesis. - Wikidata - awgldk - TriplyDB

CDK inhibitors p18(INK4c) and p27(Kip1) mediate two separate pathways to collaboratively suppress pituitary tumorigenesis.

CDK inhibitors p18(INK4c) and p27(Kip1) mediate two separate pathways to collaboratively suppress pituitary tumorigenesis.

http://www.wikidata.org/entity/Q35209756

about

Menin and MLL cooperatively regulate expression of cyclin-dependent kinase inhibitors Germ line transmission of the Cdk4(R24C) mutation facilitates tumorigenesis and escape from cellular senescence.Postnatal neuronal proliferation in mice lacking Ink4d and Kip1 inhibitors of cyclin-dependent kinases Differential gene expression of p27Kip1 and Rb knockout pituitary tumors associated with altered growth and angiogenesis Murine models and cell lines for the investigation of pheochromocytoma: applications for future therapies?EZH2 is highly expressed in pituitary adenomas and associated with proliferation A GRFa2/Prop1/stem (GPS) cell niche in the pituitary Distinct versus redundant properties among members of the INK4 family of cyclin-dependent kinase inhibitors Lack of p19INK4d in human testicular germ-cell tumours contrasts with high expression during normal spermatogenesis The INK4 family of cell cycle inhibitors in cancer Regulation of the human cyclin-dependent kinase inhibitor p18INK4c by the transcription factors E2F1 and Sp1 An important role of CDK inhibitor p18(INK4c) in modulating antigen receptor-mediated T cell proliferation Menin regulates pancreatic islet growth by promoting histone methylation and expression of genes encoding p27Kip1 and p18INK4c The ink4a/arf tumor suppressors cooperate with p21cip1/waf in the processes of mouse epidermal differentiation, senescence, and carcinogenesis Molecular cloning and characterization of the human p19INK4dgene promoter An essential role for Ink4 and Cip/Kip cell-cycle inhibitors in preventing replicative stress Altered trophoblast proliferation is insufficient to account for placental dysfunction in Egfr null embryos p27kip1: a multifunctional cyclin-dependent kinase inhibitor with prognostic significance in human cancers.E2F1 and E2F2 determine thresholds for antigen-induced T-cell proliferation and suppress tumorigenesis.Mechanisms for pituitary tumorigenesis: the plastic pituitary.Cooperation between cyclin E and p27(Kip1) in pituitary tumorigenesis.Pituitary gland development and disease: from stem cell to hormone production p19Ink4d is a tumor suppressor and controls pituitary anterior lobe cell proliferation A new functional classification of tumor-suppressing genes and its therapeutic implications.Multiple functions of p27(Kip1) and its alterations in tumor cells: a review.Enhanced LH action in transgenic female mice expressing hCGbeta-subunit induces pituitary prolactinomas; the role of high progesterone levels Genetic analysis of mammalian cyclin-dependent kinases and their inhibitors.Targeted disruption of CDK4 delays cell cycle entry with enhanced p27(Kip1) activity.INK4d-deficient mice are fertile despite testicular atrophy Cooperation of p27(Kip1) and p18(INK4c) in progestin-mediated cell cycle arrest in T-47D breast cancer cells.Functional collaboration between different cyclin-dependent kinase inhibitors suppresses tumor growth with distinct tissue specificity.Control of spermatogenesis in mice by the cyclin D-dependent kinase inhibitors p18(Ink4c) and p19(Ink4d)Genetically engineered mouse models of pituitary tumors Loss of function of the tumor suppressor DKC1 perturbs p27 translation control and contributes to pituitary tumorigenesis.The molecular balancing act of p16(INK4a) in cancer and aging.MEN1 tumorigenesis in the pituitary and pancreatic islet requires Cdk4 but not Cdk2.Wide spectrum of tumors in knock-in mice carrying a Cdk4 protein insensitive to INK4 inhibitors.Mouse models of endocrine tumours.The tumor suppressors Ink4c and p53 collaborate independently with Patched to suppress medulloblastoma formation.Patterns of p57Kip2 expression in embryonic rat brain suggest roles in progenitor cell cycle exit and neuronal differentiation

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CDK inhibitors p18(INK4c) and p27(Kip1) mediate two separate pathways to collaboratively suppress pituitary tumorigenesis.

http://www.wikidata.org/entity/Q35209756

description

1998 nî lūn-bûn

@nan

1998 թուականի Սեպտեմբերին հրատարակուած գիտական յօդուած

@hyw

1998 թվականի սեպտեմբերին հրատարակված գիտական հոդված

@hy

1998年の論文

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1998年論文

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1998年論文

@zh-hant

1998年論文

@zh-hk

1998年論文

@zh-mo

1998年論文

@zh-tw

1998年论文

@wuu

name

CDK inhibitors p18(INK4c) and ...... press pituitary tumorigenesis.

@ast

CDK inhibitors p18(INK4c) and ...... press pituitary tumorigenesis.

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type

label

CDK inhibitors p18(INK4c) and ...... press pituitary tumorigenesis.

@ast

CDK inhibitors p18(INK4c) and ...... press pituitary tumorigenesis.

@en

prefLabel

CDK inhibitors p18(INK4c) and ...... press pituitary tumorigenesis.

@ast

CDK inhibitors p18(INK4c) and ...... press pituitary tumorigenesis.

@en

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Genes & Development

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CDK inhibitors p18(INK4c) and ...... press pituitary tumorigenesis.

@en

P2093

D S Franklin

http://www.w3.org/2001/XMLSchema#string

G I Kovalev

http://www.w3.org/2001/XMLSchema#string

H Lee

http://www.w3.org/2001/XMLSchema#string

L Su

http://www.w3.org/2001/XMLSchema#string

R Schoonhoven

http://www.w3.org/2001/XMLSchema#string

S Chen-Kiang

http://www.w3.org/2001/XMLSchema#string

V L Godfrey

http://www.w3.org/2001/XMLSchema#string

Y Xiong

http://www.w3.org/2001/XMLSchema#string

P2860

Growth suppression by p18, a p16INK4/MTS1- and p14INK4B/MTS2-related CDK6 inhibitor, correlates with wild-type pRb function

Identification of G1 kinase activity for cdk6, a novel cyclin D partner

Subunit rearrangement of the cyclin-dependent kinases is associated with cellular transformation

The subcellular locations of p15(Ink4b) and p27(Kip1) coordinate their inhibitory interactions with cdk4 and cdk2

Neonatal lethality and lymphopenia in mice with a homozygous disruption of the c-abl proto-oncogene

Cancer cell cycles

Principles of CDK regulation

Inhibitors of mammalian G1 cyclin-dependent kinases

G1 phase progression: cycling on cue

Mice lacking p27(Kip1) display increased body size, multiple organ hyperplasia, retinal dysplasia, and pituitary tumors

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2899-2911

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scholarly article

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10.1101/GAD.12.18.2899

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P433

18

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P478

12

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1998-09-01T00:00:00Z

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13540762

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P698

9744866

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P932

317173

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