Rationally designed small compounds inhibit pilus biogenesis in uropathogenic bacteria.
about
Crystal structure of the FimD usher bound to its cognate FimC-FimH substrateChaperone-usher pathways: diversity and pilus assembly mechanismThe effects of antibiotics on the microbiome throughout development and alternative approaches for therapeutic modulationAdhesive Pili in UTI Pathogenesis and Drug DevelopmentVirulence and Fitness Determinants of Uropathogenic Escherichia coliExceptionally widespread nanomachines composed of type IV pilins: the prokaryotic Swiss Army knivesChemical inhibitors of the type three secretion system: disarming bacterial pathogensUrinary tract infections: epidemiology, mechanisms of infection and treatment optionsAntibiotic alternatives: the substitution of antibiotics in animal husbandry?Adhesive fiber stratification in uropathogenic Escherichia coli biofilms unveils oxygen-mediated control of type 1 piliCrystal structure of the ternary FimC-FimF(t)-FimD(N) complex indicates conserved pilus chaperone-subunit complex recognition by the usher FimDDesign and Synthesis of C-2 Substituted Thiazolo and Dihydrothiazolo Ring-Fused 2-Pyridones: Pilicides with Increased Antivirulence ActivityStructural and Functional Characterization of Pseudomonas aeruginosa CupB ChaperonesComparative Sequence, Structure and Redox Analyses of Klebsiella pneumoniae DsbA Show That Anti-Virulence Target DsbA Enzymes Fall into Distinct ClassesNitazoxanide Inhibits Pilus Biogenesis by Interfering with Folding of the Usher Protein in the Outer MembraneA 2-pyridone-amide inhibitor targets the glucose metabolism pathway of Chlamydia trachomatis.Nitazoxanide inhibits biofilm production and hemagglutination by enteroaggregative Escherichia coli strains by blocking assembly of AafA fimbriae.Escherichia coli resistance to nonbiocidal antibiofilm polysaccharides is rare and mediated by multiple mutations leading to surface physicochemical modificationsSmall-molecule inhibitors target Escherichia coli amyloid biogenesis and biofilm formation.Novel strategies to combat bacterial virulence.Syntheses and biological evaluation of 2-amino-3-acyl-tetrahydrobenzothiophene derivatives; antibacterial agents with antivirulence activityQseC-mediated dephosphorylation of QseB is required for expression of genes associated with virulence in uropathogenic Escherichia coli.The influence of pH on the specific adhesion of P piliated Escherichia coliRecent advances in understanding enteric pathogenic Escherichia coli.Transposon mutagenesis identifies uropathogenic Escherichia coli biofilm factors.Pilicide ec240 disrupts virulence circuits in uropathogenic Escherichia coli.Chemical biology applied to the study of bacterial pathogens.N-substituted 2-aminoimidazole inhibitors of MRSA biofilm formation accessed through direct 1,3-bis(tert-butoxycarbonyl)guanidine cyclization.Pilicides inhibit the FGL chaperone/usher assisted biogenesis of the Dr fimbrial polyadhesin from uropathogenic Escherichia coliStructural biology of the chaperone-usher pathway of pilus biogenesisTargeting virulence not viability in the search for future antibacterials.Structure/function analysis of Neisseria meningitidis PilW, a conserved protein that plays multiple roles in type IV pilus biologyMechanisms of protein oligomerization: inhibitor of functional amyloids templates α-synuclein fibrillation.Structural Insight into Archaic and Alternative Chaperone-Usher Pathways Reveals a Novel Mechanism of Pilus Biogenesis.The Biology of the Escherichia coli Extracellular MatrixPeptidomimetic Small Molecules Disrupt Type IV Secretion System Activity in Diverse Bacterial Pathogens.Lead optimization studies on FimH antagonists: discovery of potent and orally bioavailable ortho-substituted biphenyl mannosidesCombinatorial small-molecule therapy prevents uropathogenic Escherichia coli catheter-associated urinary tract infections in mice.Distinguishing the contribution of type 1 pili from that of other QseB-misregulated factors when QseC is absent during urinary tract infection.Structure, Function, and Assembly of Adhesive Organelles by Uropathogenic Bacteria
P2860
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P2860
Rationally designed small compounds inhibit pilus biogenesis in uropathogenic bacteria.
description
2006 nî lūn-bûn
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2006 թուականի Նոյեմբերին հրատարակուած գիտական յօդուած
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2006 թվականի նոյեմբերին հրատարակված գիտական հոդված
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2006年の論文
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2006年論文
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2006年論文
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2006年論文
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2006年論文
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2006年論文
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2006年论文
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name
Rationally designed small compounds inhibit pilus biogenesis in uropathogenic bacteria.
@ast
Rationally designed small compounds inhibit pilus biogenesis in uropathogenic bacteria.
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type
label
Rationally designed small compounds inhibit pilus biogenesis in uropathogenic bacteria.
@ast
Rationally designed small compounds inhibit pilus biogenesis in uropathogenic bacteria.
@en
prefLabel
Rationally designed small compounds inhibit pilus biogenesis in uropathogenic bacteria.
@ast
Rationally designed small compounds inhibit pilus biogenesis in uropathogenic bacteria.
@en
P2093
P2860
P50
P356
P1476
Rationally designed small compounds inhibit pilus biogenesis in uropathogenic bacteria
@en
P2093
Andreas Larsson
Eric Miller
Floris Buelens
Gabriel Waksman
Han Remaut
Jerome S Pinkner
Mattias Hedenström
Patrick Seed
Veronica Aberg
P2860
P304
17897-17902
P356
10.1073/PNAS.0606795103
P407
P577
2006-11-10T00:00:00Z