Biology-oriented synthesis: harnessing the power of evolution.
about
Accessing Nature's diversity through metabolic engineering and synthetic biologyCapturing Biological Activity in Natural Product Fragments by Chemical SynthesisNeuritogenic militarinone-inspired 4-hydroxypyridones target the stress pathway kinase MAP4K4CFam: a chemical families database based on iterative selection of functional seeds and seed-directed compound clustering.Extending accessible chemical space for the identification of novel leads.Charting Biologically Relevant Spirocyclic Compound Space.A Tryptoline Ring-Distortion Strategy Leads to Complex and Diverse Biologically Active Molecules from the Indole Alkaloid Yohimbine.Tetrahydroisoquinolines: New Inhibitors of Neutrophil Extracellular Trap (NET) Formation.Highly Stereoselective Synthesis of a Compound Collection Based on the Bicyclic Scaffolds of Natural Products.Design and synthesis of analogues of natural products.Discovery of novel drug targets and their functions using phenotypic screening of natural products.Enantioselective Organocatalytic Synthesis of a Secoyohimbane-Inspired Compound Collection with Neuritogenic Activity.(-)-Englerin A is a potent and selective activator of TRPC4 and TRPC5 calcium channels.Access to a Structurally Complex Compound Collection via Ring Distortion of the Alkaloid Sinomenine.Unveiling (-)-Englerin A as a Modulator of L-Type Calcium Channels.The natural productome.Cheminformatic characterization of natural products from Panama.Synthesis and Demonstration of the Biological Relevance of sp3 -rich Scaffolds Distantly Related to Natural Product Frameworks.Harnessing the potential of natural products in drug discovery from a cheminformatics vantage point.Traceless Solid-Phase Synthesis of Fused Chiral Macrocycles via Conformational Constraint-Assisted Cyclic Iminium Formation.Highly Enantioselective Catalytic Vinylogous Propargylation of Coumarins Yields a Class of Autophagy Inhibitors.Domino Staudinger/aza-Wittig/Mannich Reaction: An Approach to Diversity of Di- and Tetrahydropyrrole Scaffolds.Exploration of a Au(i)-mediated three-component reaction for the synthesis of DNA-tagged highly substituted spiroheterocycles.Enantiodivergent Combination of Natural Product Scaffolds Enabled by Catalytic Enantioselective Cycloaddition.Diastereoselective synthesis of novel heterocyclic scaffolds through tandem Petasis 3-component/intramolecular Diels-Alder and ROM-RCM reactions.Enantioselective synthesis of cyclopenta[b]benzofurans via an organocatalytic intramolecular double cyclization.Phosphine-catalyzed dearomatizing [3+2] annulations of isoquinolinium methylides with allenes.Divergent solid-phase synthesis of natural product-inspired bipartite cyclodepsipeptides: total synthesis of seragamide A.A biosynthesis-inspired approach to over twenty diverse natural product-like scaffolds.Discovery of Novel Cinchona-Alkaloid-Inspired Oxazatwistane Autophagy Inhibitors.Highly Enantioselective Catalytic Vinylogous Propargylation of Coumarins Yields a Class of Autophagy InhibitorsBiology-Oriented Synthesis of a Withanolide-Inspired Compound Collection Reveals Novel Modulators of Hedgehog SignalingCatalytic Aerobic Oxidation and Tandem Enantioselective Cycloaddition in Cascade Multicomponent SynthesisHighly Enantioselective Intramolecular 1,3-Dipolar Cycloaddition: A Route to Piperidino-PyrrolizidinesRhodium(II)-Catalyzed Enantioselective Synthesis of Troponoids
P2860
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P2860
Biology-oriented synthesis: harnessing the power of evolution.
description
2014 nî lūn-bûn
@nan
2014 թուականի Օգոստոսին հրատարակուած գիտական յօդուած
@hyw
2014 թվականի օգոստոսին հրատարակված գիտական հոդված
@hy
2014年の論文
@ja
2014年論文
@yue
2014年論文
@zh-hant
2014年論文
@zh-hk
2014年論文
@zh-mo
2014年論文
@zh-tw
2014年论文
@wuu
name
Biology-oriented synthesis: harnessing the power of evolution.
@ast
Biology-oriented synthesis: harnessing the power of evolution.
@en
type
label
Biology-oriented synthesis: harnessing the power of evolution.
@ast
Biology-oriented synthesis: harnessing the power of evolution.
@en
prefLabel
Biology-oriented synthesis: harnessing the power of evolution.
@ast
Biology-oriented synthesis: harnessing the power of evolution.
@en
P356
P1476
Biology-oriented synthesis: harnessing the power of evolution.
@en
P2093
Hilde van Hattum
P304
11853-11859
P356
10.1021/JA505861D
P407
P577
2014-08-05T00:00:00Z