Functions of yeast Hsp40 chaperone Sis1p dispensable for prion propagation but important for prion curing and protection from prion toxicity.
about
Disaggregases, molecular chaperones that resolubilize protein aggregatesModulation and elimination of yeast prions by protein chaperones and co-chaperonesYeast prions: structure, biology, and prion-handling systemsThe [RNQ+] prion: a model of both functional and pathological amyloidYeast prions are useful for studying protein chaperones and protein quality controlInfluence of prion variant and yeast strain variation on prion-molecular chaperone requirementsHsp104 overexpression cures Saccharomyces cerevisiae [PSI+] by causing dissolution of the prion seedsOverexpression of the essential Sis1 chaperone reduces TDP-43 effects on toxicity and proteolysis.Hsp40s specify functions of Hsp104 and Hsp90 protein chaperone machines.Functional diversification of hsp40: distinct j-protein functional requirements for two prions allow for chaperone-dependent prion selectionLocalization of HET-S to the cell periphery, not to [Het-s] aggregates, is associated with [Het-s]-HET-S toxicity.[PSI+] Prion transmission barriers protect Saccharomyces cerevisiae from infection: intraspecies 'species barriers'.Discovering protein-based inheritance through yeast genetics.Sequestration of Sup35 by aggregates of huntingtin fragments causes toxicity of [PSI+] yeast.Hsp40 function in yeast prion propagation: Amyloid diversity necessitates chaperone functional complexity.Prions in yeast.Prokaryotic chaperones support yeast prions and thermotolerance and define disaggregation machinery interactionsStructural variants of yeast prions show conformer-specific requirements for chaperone activity.Human J-protein DnaJB6b Cures a Subset of Saccharomyces cerevisiae Prions and Selectively Blocks Assembly of Structurally Related Amyloids.Schizosaccharomyces pombe disaggregation machinery chaperones support Saccharomyces cerevisiae growth and prion propagation.Prions, Chaperones, and Proteostasis in Yeast.The small heat shock protein Hsp31 cooperates with Hsp104 to modulate Sup35 prion aggregation.Hsp104 disaggregase at normal levels cures many [PSI+] prion variants in a process promoted by Sti1p, Hsp90, and Sis1p.Broadening the functionality of a J-protein/Hsp70 molecular chaperone system.Curing of [PSI+] by Hsp104 overexpression: clues to solving the puzzle.Differential effects of chaperones on yeast prions: CURrent view.Molecular dynamics simulations of Hsp40 J-domain mutants identifies disruption of the critical HPD-motif as the key factor for impaired curing in vivo of the yeast prion [URE3].To CURe or not to CURe? Differential effects of the chaperone sorting factor Cur1 on yeast prions are mediated by the chaperone Sis1.Chaperone functional specificity promotes yeast prion diversity.Nonsense-mediated mRNA decay factors cure most [PSI+] prion variants.Variant-specific and reciprocal Hsp40 functions in Hsp104-mediated prion elimination.
P2860
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P2860
Functions of yeast Hsp40 chaperone Sis1p dispensable for prion propagation but important for prion curing and protection from prion toxicity.
description
2011 nî lūn-bûn
@nan
2011 թուականի Մայիսին հրատարակուած գիտական յօդուած
@hyw
2011 թվականի մայիսին հրատարակված գիտական հոդված
@hy
2011年の論文
@ja
2011年論文
@yue
2011年論文
@zh-hant
2011年論文
@zh-hk
2011年論文
@zh-mo
2011年論文
@zh-tw
2011年论文
@wuu
name
Functions of yeast Hsp40 chape ...... rotection from prion toxicity.
@ast
Functions of yeast Hsp40 chape ...... rotection from prion toxicity.
@en
type
label
Functions of yeast Hsp40 chape ...... rotection from prion toxicity.
@ast
Functions of yeast Hsp40 chape ...... rotection from prion toxicity.
@en
prefLabel
Functions of yeast Hsp40 chape ...... rotection from prion toxicity.
@ast
Functions of yeast Hsp40 chape ...... rotection from prion toxicity.
@en
P2860
P1433
P1476
Functions of yeast Hsp40 chape ...... protection from prion toxicity
@en
P2093
Daniel C Masison
P Aaron Kirkland
P2860
P304
P356
10.1534/GENETICS.111.129460
P407
P577
2011-05-09T00:00:00Z