Why has it been so difficult to prove the efficacy of alpha-1-antitrypsin replacement therapy? Insights from the study of disease pathogenesis

Why has it been so difficult to prove the efficacy of alpha-1-antitrypsin replacement therapy? Insights from the study of disease pathogenesis

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http://www.wikidata.org/entity/Q35233352
Challenges and Prospects for Alpha-1 Antitrypsin Deficiency Gene TherapyA novel SERPINA1 mutation causing serum alpha(1)-antitrypsin deficiency.Therapy with plasma purified alpha1-antitrypsin (Prolastin®) induces time-dependent changes in plasma levels of MMP-9 and MPO.The effects of weekly augmentation therapy in patients with PiZZ α1-antitrypsin deficiency.Enhancing Autophagy with Drugs or Lung-directed Gene Therapy Reverses the Pathological Effects of Respiratory Epithelial Cell Proteinopathy.The endoplasmic reticulum remains functionally connected by vesicular transport after its fragmentation in cells expressing Z-α1-antitrypsin.Antisense oligonucleotide treatment ameliorates alpha-1 antitrypsin-related liver disease in mice.An antibody that prevents serpin polymerisation acts by inducing a novel allosteric behaviour.Mysteries of α1-antitrypsin deficiency: emerging therapeutic strategies for a challenging disease.An antibody raised against a pathogenic serpin variant induces mutant-like behaviour in the wild-type protein.Using antisense technology to develop a novel therapy for α-1 antitrypsin deficient (AATD) liver disease and to model AATD lung disease.Alpha 1 antitrypsin distribution in an allergic asthmatic population sensitized to house dust mites
P2860

Why has it been so difficult to prove the efficacy of alpha-1-antitrypsin replacement therapy? Insights from the study of disease pathogenesis

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http://www.wikidata.org/entity/Q35233352
description
2011 nî lūn-bûn
@nan
2011 թուականի Օգոստոսին հրատարակուած գիտական յօդուած
@hyw
2011 թվականի օգոստոսին հրատարակված գիտական հոդված
@hy
2011年の論文
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2011年論文
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2011年論文
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2011年論文
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2011年論文
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2011年論文
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2011年论文
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name
Why has it been so difficult t ...... study of disease pathogenesis
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Why has it been so difficult t ...... study of disease pathogenesis
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Why has it been so difficult t ...... study of disease pathogenesis
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Why has it been so difficult t ...... study of disease pathogenesis
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Why has it been so difficult t ...... study of disease pathogenesis
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Why has it been so difficult t ...... study of disease pathogenesis
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P2093
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Why has it been so difficult t ...... study of disease pathogenesis
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P2093
P2860
P304
P31
P356
P407
P478
P577
P5875
P698
P921
P932