The Z mutation alters the global structural dynamics of α1-antitrypsin.
about
Common coding variant in SERPINA1 increases the risk for large artery stroke.SVIP regulates Z variant alpha-1 antitrypsin retro-translocation by inhibiting ubiquitin ligase gp78.Deficiency Mutations of Alpha-1 Antitrypsin. Effects on Folding, Function, and Polymerization.Molecular Mechanism of Z α1-Antitrypsin DeficiencySmoothing a rugged protein folding landscape by sequence-based redesign.An integrative approach combining ion mobility mass spectrometry, X-ray crystallography, and nuclear magnetic resonance spectroscopy to study the conformational dynamics of α1 -antitrypsin upon ligand binding.Ni(ii) ions cleave and inactivate human alpha-1 antitrypsin hydrolytically, implicating nickel exposure as a contributing factor in pathologies related to antitrypsin deficiency.
P2860
Q33556760-34811243-F2DC-4635-A7D3-2162C260C565Q36310506-F99C79AA-425F-4167-AB80-90AE71977C8BQ36549080-74A17952-AD83-4728-8F10-B34C54C7D754Q37117306-330BDD32-0CB2-4B7D-AA6A-3CA4710D3F71Q37282499-43B24723-704E-402C-BC03-8540B9D36A75Q40900972-9F1A17A8-3991-4C32-A62E-12AA3B460424Q42702912-D57CE440-3890-42FC-9E05-C2D1B763C3D6
P2860
The Z mutation alters the global structural dynamics of α1-antitrypsin.
description
2014 nî lūn-bûn
@nan
2014 թուականի Սեպտեմբերին հրատարակուած գիտական յօդուած
@hyw
2014 թվականի սեպտեմբերին հրատարակված գիտական հոդված
@hy
2014年の論文
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2014年論文
@yue
2014年論文
@zh-hant
2014年論文
@zh-hk
2014年論文
@zh-mo
2014年論文
@zh-tw
2014年论文
@wuu
name
The Z mutation alters the global structural dynamics of α1-antitrypsin.
@ast
The Z mutation alters the global structural dynamics of α1-antitrypsin.
@en
type
label
The Z mutation alters the global structural dynamics of α1-antitrypsin.
@ast
The Z mutation alters the global structural dynamics of α1-antitrypsin.
@en
prefLabel
The Z mutation alters the global structural dynamics of α1-antitrypsin.
@ast
The Z mutation alters the global structural dynamics of α1-antitrypsin.
@en
P2093
P2860
P1433
P1476
The Z mutation alters the global structural dynamics of α1-antitrypsin.
@en
P2093
Patrick L Wintrode
Robert Meklemburg
Stephen P Bottomley
Victoria A Hughes
P2860
P304
P356
10.1371/JOURNAL.PONE.0102617
P407
P577
2014-09-02T00:00:00Z