Genetic variation in the CHRNA5 gene affects mRNA levels and is associated with risk for alcohol dependence
about
Meta-analysis and imputation refines the association of 15q25 with smoking quantityVariation in nicotinic acetylcholine receptor genes is associated with multiple substance dependence phenotypesNicotinic acetylcholine receptors: upregulation, age-related effects and associations with drug useUpdates on the COPD gene listThe genetics of substance dependenceFrom men to mice: CHRNA5/CHRNA3, smoking behavior and diseaseA Genetic Animal Model of Alcoholism for Screening Medications to Treat Addiction.The role of the habenula in drug addiction.Multiple independent loci at chromosome 15q25.1 affect smoking quantity: a meta-analysis and comparison with lung cancer and COPD.Alternative CHRNB4 3'-UTRs mediate the allelic effects of SNP rs1948 on gene expressionRare, low frequency and common coding variants in CHRNA5 and their contribution to nicotine dependence in European and African AmericansALDH2 is associated to alcohol dependence and is the major genetic determinant of "daily maximum drinks" in a GWAS study of an isolated rural Chinese sampleContribution of Variants in CHRNA5/A3/B4 Gene Cluster on Chromosome 15 to Tobacco Smoking: From Genetic Association to Mechanism.New insights into the genetics of addictionTransgenic over expression of nicotinic receptor alpha 5, alpha 3, and beta 4 subunit genes reduces ethanol intake in mice.Modulation of ethanol consumption by genetic and pharmacological manipulation of nicotinic acetylcholine receptors in mice.Subtypes of nicotinic acetylcholine receptors in nicotine reward, dependence, and withdrawal: evidence from genetically modified mice.The alpha 3 subunit gene of the nicotinic acetylcholine receptor is a candidate gene for ethanol stimulationProfiling of childhood adversity-associated DNA methylation changes in alcoholic patients and healthy controls.Functional characterization improves associations between rare non-synonymous variants in CHRNB4 and smoking behavior.Identification of CHRNA5 rare variants in African-American heavy smokersCHRNA5 and CHRNA3 variants and level of neuroticism in young adult Mexican American men and women.Genetics and genomics of alcohol sensitivityChanges in gene expression in regions of the extended amygdala of alcohol-preferring rats after binge-like alcohol drinking.Variants near CHRNA3/5 and APOE have age- and sex-related effects on human lifespan.Mechanisms and genetic factors underlying co-use of nicotine and alcohol or other drugs of abuse.Candidate genes for alcohol preference identified by expression profiling in alcohol-preferring and -nonpreferring reciprocal congenic rats.The CHRNA5-CHRNA3-CHRNB4 nicotinic receptor subunit gene cluster affects risk for nicotine dependence in African-Americans and in European-Americans.SNPs in CHRNA6 and CHRNB3 are associated with alcohol consumption in a nationally representative sample.The Genetics, Neurogenetics and Pharmacogenetics of AddictionGenome-wide association study of alcohol dependence implicates a region on chromosome 11.Smoking related cancers and loci at chromosomes 15q25, 5p15, 6p22.1 and 6p21.33 in the Polish population.The nicotinic acetylcholine receptor CHRNA5/A3/B4 gene cluster: dual role in nicotine addiction and lung cancerCHRNA5 variants moderate the effect of nicotine deprivation on a neural index of cognitive controlNeuronal nicotinic acetylcholine receptors: common molecular substrates of nicotine and alcohol dependence.Nicotinic α5 receptor subunit mRNA expression is associated with distant 5' upstream polymorphisms.Scientific overview: 2013 BBC plenary symposium on tobacco addiction.Loci identified by genome-wide association studies influence different disease-related phenotypes in chronic obstructive pulmonary disease.A complex interplay between personality domains, marital status and a variant in CHRNA5 on the risks of cocaine, nicotine dependences and cocaine-induced paranoia.Susceptibility loci for lung cancer are associated with mRNA levels of nearby genes in the lung.
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P2860
Genetic variation in the CHRNA5 gene affects mRNA levels and is associated with risk for alcohol dependence
description
2008 nî lūn-bûn
@nan
2008 թուականի Ապրիլին հրատարակուած գիտական յօդուած
@hyw
2008 թվականի ապրիլին հրատարակված գիտական հոդված
@hy
2008年の論文
@ja
2008年論文
@yue
2008年論文
@zh-hant
2008年論文
@zh-hk
2008年論文
@zh-mo
2008年論文
@zh-tw
2008年论文
@wuu
name
Genetic variation in the CHRNA ...... th risk for alcohol dependence
@ast
Genetic variation in the CHRNA ...... th risk for alcohol dependence
@en
type
label
Genetic variation in the CHRNA ...... th risk for alcohol dependence
@ast
Genetic variation in the CHRNA ...... th risk for alcohol dependence
@en
prefLabel
Genetic variation in the CHRNA ...... th risk for alcohol dependence
@ast
Genetic variation in the CHRNA ...... th risk for alcohol dependence
@en
P2093
P2860
P50
P356
P1433
P1476
Genetic variation in the CHRNA ...... th risk for alcohol dependence
@en
P2093
A L Hinrichs
E Goldstein
L J Bierut
M Schuckit
P2860
P2888
P304
P356
10.1038/MP.2008.42
P407
P50
P577
2008-04-15T00:00:00Z