Confirmation of a double-hit model for the NF1 gene in benign neurofibromas.
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Growth of peripheral and central nervous system tumors is supported by cytoplasmic c-Fos in humans and miceToward a survey of somatic mutation of the NF1 gene in benign neurofibromas of patients with neurofibromatosis type 1.Diminished levels of the putative tumor suppressor proteins EXT1 and EXT2 in exostosis chondrocytesEpidermal growth factor receptor expression in neurofibromatosis type 1-related tumors and NF1 animal modelsSomatic deletion of the NF1 gene in a neurofibromatosis type 1-associated malignant melanoma demonstrated by digital PCR.Glomus tumors in neurofibromatosis type 1: genetic, functional, and clinical evidence of a novel associationPlexiform and dermal neurofibromas and pigmentation are caused by Nf1 loss in desert hedgehog-expressing cells.Role for the epidermal growth factor receptor in neurofibromatosis-related peripheral nerve tumorigenesis.The NF1 tumor suppressor critically regulates TSC2 and mTOR.Structural analysis of the GAP-related domain from neurofibromin and its implicationsS100B and neurofibromin immunostaining and X-inactivation patterns of laser-microdissected cells indicate a multicellular origin of some NF1-associated neurofibromas.A clinical variant of neurofibromatosis type 1: familial spinal neurofibromatosis with a frameshift mutation in the NF1 gene.Disorders of dysregulated signal traffic through the RAS-MAPK pathway: phenotypic spectrum and molecular mechanismsEpidemiology and therapies for metastatic sarcomaComparative methylome analysis of benign and malignant peripheral nerve sheath tumors.Single cell Ras-GTP analysis reveals altered Ras activity in a subpopulation of neurofibroma Schwann cells but not fibroblasts.Molecular biology of pancreatic cancer.Perinatal epidermal growth factor receptor blockade prevents peripheral nerve disruption in a mouse model reminiscent of benign world health organization grade I neurofibromaDissecting loss of heterozygosity (LOH) in neurofibromatosis type 1-associated neurofibromas: Importance of copy neutral LOH.Malignant peripheral nerve sheath tumour arising within neurofibroma. An immunohistochemical analysis in the comparison between benign and malignant components.A search for evidence of somatic mutations in the NF1 gene.Genetics of neurofibromatosis 1-associated peripheral nerve sheath tumors.NF1 deletions in S-100 protein-positive and negative cells of sporadic and neurofibromatosis 1 (NF1)-associated plexiform neurofibromas and malignant peripheral nerve sheath tumors.Skin-derived precursor cells as an in vitro modelling tool for the study of type 1 neurofibromatosisMalignant peripheral nerve sheath tumors: clinicopathological aspects, expression of p53 and survival.PTEN and NF1 inactivation in Schwann cells produces a severe phenotype in the peripheral nervous system that promotes the development and malignant progression of peripheral nerve sheath tumors.Perinatal or adult Nf1 inactivation using tamoxifen-inducible PlpCre each cause neurofibroma formationA high-throughput molecular data resource for cutaneous neurofibromas.Conditional Inactivation of Pten with EGFR Overexpression in Schwann Cells Models Sporadic MPNST.Insertional Mutagenesis Identifies a STAT3/Arid1b/β-catenin Pathway Driving Neurofibroma Initiation.Ras signaling influences permissiveness of malignant peripheral nerve sheath tumor cells to oncolytic herpesTransition state structures and the roles of catalytic residues in GAP-facilitated GTPase of Ras as elucidated by (18)O kinetic isotope effects.An inflammatory gene signature distinguishes neurofibroma Schwann cells and macrophages from cells in the normal peripheral nervous systemNeurofibromatosis type 1-associated tumours: their somatic mutational spectrum and pathogenesis.Syndrome-associated soft tissue tumours.The role of the immune system in neurofibromatosis type 1-associated nervous system tumors.Minor lesion mutational spectrum of the entire NF1 gene does not explain its high mutability but points to a functional domain upstream of the GAP-related domain.Ral overactivation in malignant peripheral nerve sheath tumors.Loss of Y chromosome in the malignant peripheral nerve sheet tumor of a patient with Neurofibromatosis type 1.KIR2DL5 mutation and loss underlies sporadic dermal neurofibroma pathogenesis and growth.
P2860
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P2860
Confirmation of a double-hit model for the NF1 gene in benign neurofibromas.
description
1997 nî lūn-bûn
@nan
1997 թուականի Սեպտեմբերին հրատարակուած գիտական յօդուած
@hyw
1997 թվականի սեպտեմբերին հրատարակված գիտական հոդված
@hy
1997年の論文
@ja
1997年論文
@yue
1997年論文
@zh-hant
1997年論文
@zh-hk
1997年論文
@zh-mo
1997年論文
@zh-tw
1997年论文
@wuu
name
Confirmation of a double-hit model for the NF1 gene in benign neurofibromas.
@ast
Confirmation of a double-hit model for the NF1 gene in benign neurofibromas.
@en
type
label
Confirmation of a double-hit model for the NF1 gene in benign neurofibromas.
@ast
Confirmation of a double-hit model for the NF1 gene in benign neurofibromas.
@en
prefLabel
Confirmation of a double-hit model for the NF1 gene in benign neurofibromas.
@ast
Confirmation of a double-hit model for the NF1 gene in benign neurofibromas.
@en
P2093
P2860
P356
P1476
Confirmation of a double-hit model for the NF1 gene in benign neurofibromas.
@en
P2093
P2860
P304
P356
10.1086/515504
P407
P577
1997-09-01T00:00:00Z