Evolutionary Action Score of TP53 Identifies High-Risk Mutations Associated with Decreased Survival and Increased Distant Metastases in Head and Neck Cancer.
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The Tip of the Iceberg: Clinical Implications of Genomic Sequencing Projects in Head and Neck CancerUET: a database of evolutionarily-predicted functional determinants of protein sequences that cluster as functional sites in protein structures.Research Strategies for Biomedical and Health Informatics. Some Thought-provoking and Critical Proposals to Encourage Scientific Debate on the Nature of Good Research in Medical Informatics.Metabolic interrogation as a tool to optimize chemotherapeutic regimens.Elucidation of G-protein and β-arrestin functional selectivity at the dopamine D2 receptorGenomic alterations in head and neck squamous cell carcinoma determined by cancer gene-targeted sequencing.RNA-Binding Protein FXR1 Regulates p21 and TERC RNA to Bypass p53-Mediated Cellular Senescence in OSCC.Human Papillomavirus 16 Infection and TP53 Mutation: Two Distinct Pathogeneses for Oropharyngeal Squamous Cell Carcinoma in an Eastern Chinese PopulationSpecific TP53 Mutants Overrepresented in Ovarian Cancer Impact CNV, TP53 Activity, Responses to Nutlin-3a, and Cell Survival.Mutant GDF15 presents a poor prognostic outcome for patients with oral squamous cell carcinomaMissense mutations in the TP53 DNA-binding domain predict outcomes in patients with advanced oral cavity squamous cell carcinoma.Clues toward precision medicine in oral squamous cell carcinoma: utility of next-generation sequencing for the prognostic stratification of high-risk patients harboring neck lymph node extracapsular extension.Objective assessment of the evolutionary action equation for the fitness effect of missense mutations across CAGI-blinded contests.TP53 Mutations in Head and Neck Squamous Cell Carcinoma and Their Impact on Disease Progression and Treatment Response.Clinicopathological features and clinical outcomes associated with TP53 and BRAFNon-V600 mutations in cutaneous melanoma patients.Classification of TP53 mutations and HPV predict survival in advanced larynx cancer.The tumor suppressor capability of p53 is dependent on non-muscle myosin IIA function in head and neck cancer.HUMAN KINASES DISPLAY MUTATIONAL HOTSPOTS AT COGNATE POSITIONS WITHIN CANCER.The tumor genome in human immunodeficiency virus-related head and neck cancer: Exploitable targets?Distinct pattern of TP53 mutations in human immunodeficiency virus-related head and neck squamous cell carcinoma.Evolutionary action and structural basis of the allosteric switch controlling β2AR functional selectivity.Gain-of-function mutant p53 promotes the oncogenic potential of head and neck squamous cell carcinoma cells by targeting the transcription factors FOXO3a and FOXM1.Genomic analysis of head and neck cancer cases from two high incidence regions.CDKN2A/p16 deletion in head and neck cancer cells is associated with Cdk2 activation, replication stress, and vulnerability to Chk1 inhibition.Replication Stress Leading to Apoptosis within the S-phase Contributes to Synergism between Vorinostat and AZD1775 in HNSCC Harboring High-Risk TP53 Mutation.High-risk TP53 mutations are associated with extra nodal extension (ENE) in oral cavity squamous cell carcinoma (OSCC).Genomic insights into head and neck cancer.Cdkn2a suppresses metastasis in squamous cell carcinomas induced by the gain-of-function mutant p53(R172H).Targeting the DNA Damage Response in OSCC with TP53 Mutations.Outcome analysis of Phase I trial patients with metastatic and/or mutant non-small cell lung cancerHallmarks of Cancer-Related Newly Prognostic Factors of Oral Squamous Cell Carcinoma
P2860
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P2860
Evolutionary Action Score of TP53 Identifies High-Risk Mutations Associated with Decreased Survival and Increased Distant Metastases in Head and Neck Cancer.
description
2015 nî lūn-bûn
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2015 թուականի Յունուարին հրատարակուած գիտական յօդուած
@hyw
2015 թվականի հունվարին հրատարակված գիտական հոդված
@hy
2015年の論文
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2015年学术文章
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2015年学术文章
@zh-cn
2015年学术文章
@zh-hans
2015年学术文章
@zh-my
2015年学术文章
@zh-sg
2015年學術文章
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name
Evolutionary Action Score of T ...... tases in Head and Neck Cancer.
@ast
Evolutionary Action Score of T ...... tases in Head and Neck Cancer.
@en
type
label
Evolutionary Action Score of T ...... tases in Head and Neck Cancer.
@ast
Evolutionary Action Score of T ...... tases in Head and Neck Cancer.
@en
prefLabel
Evolutionary Action Score of T ...... tases in Head and Neck Cancer.
@ast
Evolutionary Action Score of T ...... tases in Head and Neck Cancer.
@en
P2093
P2860
P1433
P1476
Evolutionary Action Score of T ...... stases in Head and Neck Cancer
@en
P2093
Abdullah A Osman
Adel K El-Naggar
Alexandra Ward
Ameeta Patel
Beth M Beadle
Carlos Caulin
Daisuke Sano
David M Neskey
Heath D Skinner
Jeffrey N Myers
P2860
P304
P356
10.1158/0008-5472.CAN-14-2735
P407
P577
2015-01-29T00:00:00Z