Synthesis and biological activities of (R)- and (S)-N-(4-Methoxyphenyl)-N,2,6-trimethyl-6,7-dihydro-5H-cyclopenta[d]pyrimidin-4-aminium chloride as potent cytotoxic antitubulin agents.
about
The design and discovery of water soluble 4-substituted-2,6-dimethylfuro[2,3-d]pyrimidines as multitargeted receptor tyrosine kinase inhibitors and microtubule targeting antitumor agentsPolygamain, a new microtubule depolymerizing agent that occupies a unique pharmacophore in the colchicine site.Janus Compounds, 5-Chloro-N⁴-methyl-N⁴-aryl-9H-pyrimido[4,5-b]indole-2,4-diamines, Cause Both Microtubule Depolymerizing and Stabilizing Effects.An overview of tubulin inhibitors that interact with the colchicine binding siteStructure-activity relationship and in vitro and in vivo evaluation of the potent cytotoxic anti-microtubule agent N-(4-methoxyphenyl)-N,2,6-trimethyl-6,7-dihydro-5H-cyclopenta[d]pyrimidin-4-aminium chloride and its analogues as antitumor agents.Design, Synthesis, and Preclinical Evaluation of 4-Substituted-5-methyl-furo[2,3-d]pyrimidines as Microtubule Targeting Agents That Are Effective against Multidrug Resistant Cancer Cells.How to deal with low-resolution target structures: using SAR, ensemble docking, hydropathic analysis, and 3D-QSAR to definitively map the αβ-tubulin colchicine site.Combined Molecular Docking, 3D-QSAR, and Pharmacophore Model: Design of Novel Tubulin Polymerization Inhibitors by Binding to Colchicine-binding Site.
P2860
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P2860
Synthesis and biological activities of (R)- and (S)-N-(4-Methoxyphenyl)-N,2,6-trimethyl-6,7-dihydro-5H-cyclopenta[d]pyrimidin-4-aminium chloride as potent cytotoxic antitubulin agents.
description
2011 nî lūn-bûn
@nan
2011 թուականի Օգոստոսին հրատարակուած գիտական յօդուած
@hyw
2011 թվականի օգոստոսին հրատարակված գիտական հոդված
@hy
2011年の論文
@ja
2011年論文
@yue
2011年論文
@zh-hant
2011年論文
@zh-hk
2011年論文
@zh-mo
2011年論文
@zh-tw
2011年论文
@wuu
name
Synthesis and biological activ ...... cytotoxic antitubulin agents.
@ast
Synthesis and biological activ ...... cytotoxic antitubulin agents.
@en
type
label
Synthesis and biological activ ...... cytotoxic antitubulin agents.
@ast
Synthesis and biological activ ...... cytotoxic antitubulin agents.
@en
prefLabel
Synthesis and biological activ ...... cytotoxic antitubulin agents.
@ast
Synthesis and biological activ ...... cytotoxic antitubulin agents.
@en
P2093
P2860
P356
P1476
Synthesis and biological activ ...... cytotoxic antitubulin agents.
@en
P2093
Aleem Gangjee
Cara Westbrook
Ernest Hamel
Susan L Mooberry
P2860
P304
P356
10.1021/JM2007722
P407
P577
2011-08-05T00:00:00Z