Cellular content of UDP-N-acetylhexosamines controls hyaluronan synthase 2 expression and correlates with O-linked N-acetylglucosamine modification of transcription factors YY1 and SP1.
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Hyaluronan synthase 2 (HAS2) promotes breast cancer cell invasion by suppression of tissue metalloproteinase inhibitor 1 (TIMP-1)Hyaluronan Synthase: The Mechanism of Initiation at the Reducing End and a Pendulum Model for Polysaccharide Translocation to the Cell ExteriorThe oncogenic role of Yin Yang 1Rho-kinase inhibitor Y-27632 and hypoxia synergistically enhance chondrocytic phenotype and modify S100 protein profiles in human chondrosarcoma cells.Natural antisense transcript for hyaluronan synthase 2 (HAS2-AS1) induces transcription of HAS2 via protein O-GlcNAcylation.Global mass spectrometry and transcriptomics array based drug profiling provides novel insight into glucosamine induced endoplasmic reticulum stressSuppressive regulation of KSHV RTA with O-GlcNAcylation.4-Methylumbelliferone Diminishes Catabolically Activated Articular Chondrocytes and Cartilage Explants via a Mechanism Independent of Hyaluronan Inhibition.TRIB3 mediates glucose-induced insulin resistance via a mechanism that requires the hexosamine biosynthetic pathway.Heparin prevents intracellular hyaluronan synthesis and autophagy responses in hyperglycemic dividing mesangial cells and activates synthesis of an extensive extracellular monocyte-adhesive hyaluronan matrix after completing cell division.Therapeutic targeting of hyaluronan in the tumor stroma.The dynamic metabolism of hyaluronan regulates the cytosolic concentration of UDP-GlcNAc.UDP-sugar substrates of HAS3 regulate its O-GlcNAcylation, intracellular traffic, extracellular shedding and correlate with melanoma progression.Impaired Synthesis of Stromal Components in Response to Minnelide Improves Vascular Function, Drug Delivery, and Survival in Pancreatic Cancer.Role of UDP-N-acetylglucosamine (GlcNAc) and O-GlcNAcylation of hyaluronan synthase 2 in the control of chondroitin sulfate and hyaluronan synthesis.YY1 directly suppresses MYCT1 leading to laryngeal tumorigenesis and progressExtracellular UDP-glucose activates P2Y14 Receptor and Induces Signal Transducer and Activator of Transcription 3 (STAT3) Tyr705 phosphorylation and binding to hyaluronan synthase 2 (HAS2) promoter, stimulating hyaluronan synthesis of keratinocytes.Hyaluronan synthase 1 (HAS1) requires higher cellular UDP-GlcNAc concentration than HAS2 and HAS3.Mannose reduces hyaluronan and leukocytes in wound granulation tissue and inhibits migration and hyaluronan-dependent monocyte binding.Increased hyaluronan content and stromal cell CD44 associate with HER2 positivity and poor prognosis in human breast cancer.A Trickster in Disguise: Hyaluronan's Ambivalent Roles in the Matrix.Hyaluronan synthase control of synthesis rate and hyaluronan product size are independent functions differentially affected by mutations in a conserved tandem B-X7-B motif.Altered expression of hyaluronan synthase and hyaluronidase mRNA may affect hyaluronic acid distribution in keloid disease compared with normal skin.Rho-kinase inhibitor Y-27632 increases cellular proliferation and migration in human foreskin fibroblast cells.Peroxisome proliferator-activated receptor γ agonists attenuate hyperglycaemia-induced hyaluronan secretion in vascular smooth muscle cells by inhibiting PKCβ2.
P2860
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P2860
Cellular content of UDP-N-acetylhexosamines controls hyaluronan synthase 2 expression and correlates with O-linked N-acetylglucosamine modification of transcription factors YY1 and SP1.
description
2011 nî lūn-bûn
@nan
2011 թուականի Յուլիսին հրատարակուած գիտական յօդուած
@hyw
2011 թվականի հուլիսին հրատարակված գիտական հոդված
@hy
2011年の論文
@ja
2011年論文
@yue
2011年論文
@zh-hant
2011年論文
@zh-hk
2011年論文
@zh-mo
2011年論文
@zh-tw
2011年论文
@wuu
name
Cellular content of UDP-N-acet ...... scription factors YY1 and SP1.
@ast
Cellular content of UDP-N-acet ...... scription factors YY1 and SP1.
@en
type
label
Cellular content of UDP-N-acet ...... scription factors YY1 and SP1.
@ast
Cellular content of UDP-N-acet ...... scription factors YY1 and SP1.
@en
prefLabel
Cellular content of UDP-N-acet ...... scription factors YY1 and SP1.
@ast
Cellular content of UDP-N-acet ...... scription factors YY1 and SP1.
@en
P2093
P2860
P356
P1476
Cellular content of UDP-N-acet ...... nscription factors YY1 and SP1
@en
P2093
Elina Koli
Gerald W Hart
Katri M Makkonen
Markku I Tammi
Raija H Tammi
Riikka Kärnä
Sanna Oikari
Tiina A Jokela
P2860
P304
33632-33640
P356
10.1074/JBC.M111.265637
P407
P577
2011-07-27T00:00:00Z