about
Repacking of the transmembrane domains of P-glycoprotein during the transport ATPase cycleABC transporters: bacterial exportersMultidrug efflux pumps of gram-negative bacteriaPermissive linker insertion sites in the outer membrane protein of 987P fimbriae of Escherichia coliThe biological significance of brain barrier mechanisms: help or hindrance in drug delivery to the central nervous system?Providing a molecular mechanism for P-glycoprotein; why would I bother?Bypassing P-Glycoprotein Drug Efflux Mechanisms: Possible Applications in Pharmacoresistant Schizophrenia TherapyP-glycoprotein inhibitors of natural origin as potential tumor chemo-sensitizers: A reviewTransmembrane passage of hydrophobic compounds through a protein channel wallCrystal structure of the multidrug transporter P-glycoprotein from Caenorhabditis elegansStructural basis for gating mechanisms of a eukaryotic P-glycoprotein homolog.An ABC transporter in the mitochondrial inner membrane is required for normal growth of yeastMolecular properties of bacterial multidrug transportersRegulation of cholesterol homeostasis in macrophages and consequences for atherosclerotic lesion developmentMultidrug-resistance P-glycoprotein (MDR1) secretes platelet-activating factorLipid somersaults: Uncovering the mechanisms of protein-mediated lipid flippingRegulation of biliary lipid secretion by mdr2 P-glycoprotein in the mouseInhibition or knockdown of ABC transporters enhances susceptibility of adult and juvenile schistosomes to PraziquantelATP-dependent substrate transport by the ABC transporter MsbA is proton-coupledA synonymous polymorphism in a common MDR1 (ABCB1) haplotype shapes protein function.A novel non-natural nucleoside that influences P-glycoprotein activity and mediates drug resistanceSubnanometre-resolution electron cryomicroscopy structure of a heterodimeric ABC exporterP-glycoprotein (ABCB1) interacts directly with lipid-based anti-cancer drugs and platelet-activating factors.The ABC transporter MsbA interacts with lipid A and amphipathic drugs at different sitesBarrier mechanisms in the brain, I. Adult brain.The DrrAB efflux system of Streptomyces peucetius is a multidrug transporter of broad substrate specificityP-glycoprotein-mediated resistance to chemotherapy in cancer cells: using recombinant cytosolic domains to establish structure-function relationships.Studies of human MDR1-MDR2 chimeras demonstrate the functional exchangeability of a major transmembrane segment of the multidrug transporter and phosphatidylcholine flippaseMDR1 Ala893 polymorphism is associated with inflammatory bowel disease.Functional complementation of the ste6 gene of Saccharomyces cerevisiae with the pfmdr1 gene of Plasmodium falciparum.Functional expression and localization of P-glycoprotein at the blood brain barrier.Drug resistance in brain diseases and the role of drug efflux transporters.Overexpression of the cystic fibrosis transmembrane conductance regulator in NIH 3T3 cells lowers membrane potential and intracellular pH and confers a multidrug resistance phenotype.The multidrug transporter, P-glycoprotein, actively mediates cholesterol redistribution in the cell membrane.Mdr1 gene expression and mutations in Ras proto-oncogenes in acute myeloid leukemia.Lipid traffic: the ABC of transbilayer movement.The chlamydial inclusion preferentially intercepts basolaterally directed sphingomyelin-containing exocytic vacuoles.ATP-binding cassette transporter G2 activity in the bovine spermatozoa is modulated along the epididymal duct and at ejaculation.Pharmacogenomics of MDR1/ABCB1 gene: the influence on risk and clinical outcome of haematological malignancies.An ABC-transporter from Streptomyces longisporoflavus confers resistance to the polyether-ionophore antibiotic tetronasin.
P2860
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P2860
description
1992 nî lūn-bûn
@nan
1992 թուականի Յունուարին հրատարակուած գիտական յօդուած
@hyw
1992 թվականի հունվարին հրատարակված գիտական հոդված
@hy
1992年の論文
@ja
1992年論文
@yue
1992年論文
@zh-hant
1992年論文
@zh-hk
1992年論文
@zh-mo
1992年論文
@zh-tw
1992年论文
@wuu
name
Is the multidrug transporter a flippase?
@ast
Is the multidrug transporter a flippase?
@en
type
label
Is the multidrug transporter a flippase?
@ast
Is the multidrug transporter a flippase?
@en
prefLabel
Is the multidrug transporter a flippase?
@ast
Is the multidrug transporter a flippase?
@en
P1476
Is the multidrug transporter a flippase?
@en
P2093
Gottesman MM
Higgins CF
P356
10.1016/0968-0004(92)90419-A
P577
1992-01-01T00:00:00Z