A GCase chaperone improves motor function in a mouse model of synucleinopathy. - Wikidata - awgldk - TriplyDB

A GCase chaperone improves motor function in a mouse model of synucleinopathy.

A GCase chaperone improves motor function in a mouse model of synucleinopathy.

http://www.wikidata.org/entity/Q35340158

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The relationship between glucocerebrosidase mutations and Parkinson disease Development of targeted therapies for Parkinson's disease and related synucleinopathies Lysosomal Enzyme Glucocerebrosidase Protects against Aβ1-42 Oligomer-Induced Neurotoxicity.A New Glucocerebrosidase Chaperone Reduces α-Synuclein and Glycolipid Levels in iPSC-Derived Dopaminergic Neurons from Patients with Gaucher Disease and Parkinsonism.Progress and potential of non-inhibitory small molecule chaperones for the treatment of Gaucher disease and its implications for Parkinson disease.The ongoing pursuit of neuroprotective therapies in Parkinson disease.Pharmaceutical Chaperones and Proteostasis Regulators in the Therapy of Lysosomal Storage Disorders: Current Perspective and Future Promises.Parkinson's disease: acid-glucocerebrosidase activity and alpha-synuclein clearance.A Molecular Tweezer Ameliorates Motor Deficits in Mice Overexpressing α-Synuclein.Therapeutic potential of autophagy-enhancing agents in Parkinson's disease.New Directions in Gaucher Disease.Defects in trafficking bridge Parkinson's disease pathology and genetics.Chaperone-Based Therapies for Disease Modification in Parkinson's Disease.The lysosomal enzyme alpha-Galactosidase A is deficient in Parkinson's disease brain in association with the pathologic accumulation of alpha-synuclein.Polyethylenimine Nanoparticle-Mediated siRNA Delivery to Reduce α-Synuclein Expression in a Model of Parkinson's Disease.Effects of decreased dopamine transporter levels on nigrostriatal neurons and paraquat/maneb toxicity in mice.A de novo compound targeting α-synuclein improves deficits in models of Parkinson's disease.Pharmacoperones as Novel Therapeutics for Diverse Protein Conformational Diseases.The Transcellular Propagation and Intracellular Trafficking of α-Synuclein.Dysregulation of the autophagic-lysosomal pathway in Gaucher and Parkinson's disease.Lipid-dependent deposition of alpha-synuclein and Tau on neuronal Secretogranin II-positive vesicular membranes with age

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P2860

A GCase chaperone improves motor function in a mouse model of synucleinopathy.

http://www.wikidata.org/entity/Q35340158

description

2014 nî lūn-bûn

@nan

2014 թուականի Հոկտեմբերին հրատարակուած գիտական յօդուած

@hyw

2014 թվականի հոտեմբերին հրատարակված գիտական հոդված

@hy

2014年の論文

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2014年論文

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2014年論文

@zh-hant

2014年論文

@zh-hk

2014年論文

@zh-mo

2014年論文

@zh-tw

2014年论文

@wuu

name

A GCase chaperone improves motor function in a mouse model of synucleinopathy.

@ast

A GCase chaperone improves motor function in a mouse model of synucleinopathy.

@en

type

label

A GCase chaperone improves motor function in a mouse model of synucleinopathy.

@ast

A GCase chaperone improves motor function in a mouse model of synucleinopathy.

@en

prefLabel

A GCase chaperone improves motor function in a mouse model of synucleinopathy.

@ast

A GCase chaperone improves motor function in a mouse model of synucleinopathy.

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S13311-014-0294-X

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Neurotherapeutics

P1476

A GCase chaperone improves motor function in a mouse model of synucleinopathy.

@en

P2093

Brandon A Wustman

http://www.w3.org/2001/XMLSchema#string

Brian Ranes

http://www.w3.org/2001/XMLSchema#string

Caitlin K Mulligan

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Chunni Zhu

http://www.w3.org/2001/XMLSchema#string

David J Lockhart

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Farzad Mortazavi

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Franziska Richter

http://www.w3.org/2001/XMLSchema#string

John Flanagan

http://www.w3.org/2001/XMLSchema#string

Krystal De La Rosa

http://www.w3.org/2001/XMLSchema#string

Lee Pellegrino

http://www.w3.org/2001/XMLSchema#string

P2860

The synaptic pathology of alpha-synuclein aggregation in dementia with Lewy bodies, Parkinson's disease and Parkinson's disease dementia

Gaucher disease glucocerebrosidase and α-synuclein form a bidirectional pathogenic loop in synucleinopathies

Multicenter analysis of glucocerebrosidase mutations in Parkinson's disease.

The iminosugar isofagomine increases the activity of N370S mutant acid beta-glucosidase in Gaucher fibroblasts by several mechanisms

Dopamine-modified alpha-synuclein blocks chaperone-mediated autophagy

A progressive mouse model of Parkinson's disease: the Thy1-aSyn ("Line 61") mice

Statistical data analysis in the computer age.

Bacterial artificial chromosome transgenic mice expressing a truncated mutant parkin exhibit age-dependent hypokinetic motor deficits, dopaminergic neuron degeneration, and accumulation of proteinase K-resistant alpha-synuclein.

The pharmacological chaperone isofagomine increases the activity of the Gaucher disease L444P mutant form of beta-glucosidase.

Isofagomine in vivo effects in a neuronopathic Gaucher disease mouse.

P2888

s13311-014-0294-x

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840-856

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scholarly article

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10.1007/S13311-014-0294-X

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4

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11

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Marie-Françoise Chesselet

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2014-10-01T00:00:00Z

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264053520

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25037721

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molecular chaperones

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4391384

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