An intravaginal ring that releases the NNRTI MIV-150 reduces SHIV transmission in macaques - Wikidata - awgldk - TriplyDB

An intravaginal ring that releases the NNRTI MIV-150 reduces SHIV transmission in macaques

An intravaginal ring that releases the NNRTI MIV-150 reduces SHIV transmission in macaques

http://www.wikidata.org/entity/Q35345363

about

Parsimonious Determination of the Optimal Infectious Dose of a Pathogen for Nonhuman Primate Models Rectal HSV-2 Infection May Increase Rectal SIV Acquisition Even in the Context of SIVΔnef Vaccination A Novel Microbicide/Contraceptive Intravaginal Ring Protects Macaque Genital Mucosa against SHIV-RT Infection Ex Vivo Exposure to MIV-150 from a high-dose intravaginal ring results in limited emergence of drug resistance mutations in SHIV-RT infected rhesus macaques Engineering a segmented dual-reservoir polyurethane intravaginal ring for simultaneous prevention of HIV transmission and unwanted pregnancy Current and emerging formulation strategies for the effective transdermal delivery of HIV inhibitors "Set it and forget it": women's perceptions and opinions of long-acting topical vaginal gels Historical development of vaginal microbicides to prevent sexual transmission of HIV in women: from past failures to future hopes.Preformulation studies of EFdA, a novel nucleoside reverse transcriptase inhibitor for HIV prevention.The emerging profile of cross-resistance among the nonnucleoside HIV-1 reverse transcriptase inhibitors.A MIV-150/zinc acetate gel inhibits SHIV-RT infection in macaque vaginal explants An intravaginal ring for the sustained delivery of antibodies.Short communication: a repeated simian human immunodeficiency virus reverse transcriptase/herpes simplex virus type 2 cochallenge macaque model for the evaluation of microbicides Pharmacokinetic evaluation of tenofovir disoproxil fumarate released from an intravaginal ring in pigtailed macaques after 6 months of continuous use.Repressive effect of primary virus replication on superinfection correlated with gut-derived central memory CD4(+) T cells in SHIV-infected Chinese rhesus macaques Alternative divalent cations (Zn²⁺, Co²⁺, and Mn²⁺) are not mutagenic at conditions optimal for HIV-1 reverse transcriptase activity.MIV-150/zinc acetate gel inhibits cell-associated simian-human immunodeficiency virus reverse transcriptase infection in a macaque vaginal explant model.Low Frequency of Drug-Resistant Variants Selected by Long-Acting Rilpivirine in Macaques Infected with Simian Immunodeficiency Virus Containing HIV-1 Reverse Transcriptase.A novel intravaginal ring to prevent HIV-1, HSV-2, HPV, and unintended pregnancy In search of the optimal delivery method for anti-HIV microbicides: are intravaginal rings the way forward?Animal models for microbicide safety and efficacy testing.A modified zinc acetate gel, a potential nonantiretroviral microbicide, is safe and effective against simian-human immunodeficiency virus and herpes simplex virus 2 infection in vivo.Pharmacodynamic correlations using fresh and cryopreserved tissue following use of vaginal rings containing dapivirine and/or maraviroc in a randomized, placebo controlled trial.Intravaginal ring eluting tenofovir disoproxil fumarate completely protects macaques from multiple vaginal simian-HIV challenges.Pharmacokinetics and pharmacodynamics in HIV prevention; current status and future directions: a summary of the DAIDS and BMGF sponsored think tank on pharmacokinetics (PK)/pharmacodynamics (PD) in HIV prevention.A combination microbicide gel protects macaques against vaginal simian human immunodeficiency virus-reverse transcriptase infection, but only partially reduces herpes simplex virus-2 infection after a single high-dose cochallenge.Modified silicone elastomer vaginal gels for sustained release of antiretroviral HIV microbicides.MIV-150-containing intravaginal rings protect macaque vaginal explants against SHIV-RT infection.Methodological lessons from clinical trials and the future of microbicide research.Vaginal microbicides and their delivery platforms.MZC Gel Inhibits SHIV-RT and HSV-2 in Macaque Vaginal Mucosa and SHIV-RT in Rectal Mucosa.MIV-150 and zinc acetate combination provides potent and broad activity against HIV-1.An intravaginal ring that releases three antiviral agents and a contraceptive blocks SHIV-RT infection, reduces HSV-2 shedding, and suppresses hormonal cycling in rhesus macaques.Griffithsin carrageenan fast dissolving inserts prevent SHIV HSV-2 and HPV infections in vivo

P2860

Q27318212-96124AB0-8D36-4551-9688-CDBFAAC50031 Q27321160-874DD639-D7CF-419D-81B1-5D33B02A7135 Q27334384-928977C9-123E-4C49-B534-8406FB234560 Q28540200-2FEC443B-C8EF-4A73-BB94-D935B73ECC26 Q28540419-AE871E46-27B8-4C34-A41C-D432941B4B53 Q28545757-91CFA483-BE2B-4B0D-BB60-9B1D47673E29 Q33601303-BBCD89BF-3659-4832-AE10-DABBD3808DAF Q33821090-F65A9BF7-FD2A-4C71-8F3E-1A2FE5D8D774 Q34059879-3405FAB8-57FA-48F4-9303-95C3179A9437 Q34102246-020A373A-366D-48BC-8682-EBD5339BAB27 Q34258224-BD3F2C9F-BA01-4554-B16B-9E73073A57B1 Q34389166-58976B0C-71B3-4ED8-A954-8D3FC83620FF Q34399737-7A10F177-B84C-40C9-93D5-06F9C7281CBA Q34481177-C9846341-014E-4FAE-9843-4E166B59A661 Q34983902-086615B6-7744-4C3B-A3FF-5813FF7A03D7 Q35620768-5F20617F-BA4C-4B62-8831-2B7BC6E19913 Q35746218-55FB5582-8047-4520-AF3A-6EF25E8D5535 Q36290753-75ED49F9-7D00-42A7-B53A-36217001BAEF Q36381485-0A5F61A9-424F-46BC-A5B4-DFA941805A02 Q36630547-947FF0A1-FD0B-429D-8D2B-F6C860D09938 Q36989915-EA3AC3D6-2BCF-4C69-9D0B-95DDC61AB917 Q37036620-3206FDA5-AC30-4197-80A7-9510BBD80385 Q37116845-3830194B-B9E5-4A7E-AE51-53972487B780 Q37218578-E5B00952-1BFB-40D9-A274-F3D3E36BCCE7 Q37258271-102587F2-B16F-4150-BC1A-659856EBCDE2 Q37544128-DFEAB135-0F5B-46F9-A292-00A1D2B99993 Q37707803-0C94A496-7B44-4581-839D-F54118CAD75B Q37713059-A0EDE267-B3D9-4B8B-81BE-670EC782C8D8 Q38062882-739B64B8-2F21-44C8-AE86-A1B524A67051 Q38186138-B5675469-1705-410D-9A0B-EDE49E99A550 Q39463175-D85DBB9C-5417-46DB-9F18-5D6417BEC46B Q40081674-E78F6C14-EF94-46F9-8E36-DC821D25CF8C Q40165275-0E803EE9-ED68-472C-8A8B-A55F11CA662D Q58700581-70D9926E-4A1C-4583-9942-1E429EB11AF8

P2860

An intravaginal ring that releases the NNRTI MIV-150 reduces SHIV transmission in macaques

http://www.wikidata.org/entity/Q35345363

description

2012 nî lūn-bûn

@nan

2012 թուականի Սեպտեմբերին հրատարակուած գիտական յօդուած

@hyw

2012 թվականի սեպտեմբերին հրատարակված գիտական հոդված

@hy

2012年の論文

@ja

2012年論文

@yue

2012年論文

@zh-hant

2012年論文

@zh-hk

2012年論文

@zh-mo

2012年論文

@zh-tw

2012年论文

@wuu

name

An intravaginal ring that rele ...... SHIV transmission in macaques

@ast

An intravaginal ring that rele ...... SHIV transmission in macaques

@en

type

label

An intravaginal ring that rele ...... SHIV transmission in macaques

@ast

An intravaginal ring that rele ...... SHIV transmission in macaques

@en

prefLabel

An intravaginal ring that rele ...... SHIV transmission in macaques

@ast

An intravaginal ring that rele ...... SHIV transmission in macaques

@en

P1433

Q35345363-F45C8EF7-2D17-4445-9505-6598B39AD9BD

P1476

Q35345363-4E3FC4DB-B660-4C5C-AF48-6C6C03859BBF

P2093

Q35345363-065A36F8-F43B-4A0E-8B12-1BF9D9605016

Q35345363-5302C0FA-DE8A-411A-85BF-008808E9FA81

Q35345363-57B8BFA7-B457-4528-A695-66A9BE372F67

Q35345363-6402CD36-26D1-47E7-B4C6-969BC8A60F7B

Q35345363-763EC615-2528-4C85-8F81-9944FE0C2886

Q35345363-768672D9-5C72-418E-BF1B-E181B10BEAAE

Q35345363-795A5A52-3C6A-480B-A2C1-DC1B965E702C

Q35345363-850DD514-5561-4B68-AD7C-CDF56E686B31

Q35345363-8D455C78-567A-4B2B-AA3F-7DF1E90DEED0

Q35345363-98A085B8-194F-4351-9163-0CA54BCDE3B4

P2860

Q35345363-01EB6389-44BE-416B-A4AC-BE4A50C3AF19

Q35345363-102ACF1C-426E-43C1-8561-58F5EC7B8948

Q35345363-20CEF8BB-49EA-494F-9904-2B2B343CC17C

Q35345363-2AEFC7B7-2D96-437A-98B8-52ADBC62D77F

Q35345363-34FA1D61-A784-43C7-AE24-66401EF59FD2

Q35345363-3A207CF7-9F5A-4C99-BE7E-D6A6DA5B33FC

Q35345363-3DB4FBD4-D637-4CEF-9D8F-17B320E7FC47

Q35345363-42A759E2-F642-48AF-BAB0-2FF99ED526AE

Q35345363-44A9220F-D1C6-4398-8FA8-D83FD4A42DDE

Q35345363-48392FE8-D754-4595-AA4D-011941608947

P304

Q35345363-73DDDDCC-2C5C-4A81-9A93-340C54248BEF

P31

Q35345363-D1674191-491A-49B0-B168-B7DD720F4AF7

P356

Q35345363-8EAA89E3-C04B-417C-80A5-56BF9DEA830E

P407

Q35345363-0CAC658A-7EA1-47EA-A591-D79946D09123

P433

Q35345363-54FAD11D-02F9-40C6-BD11-DAFF256A7010

P478

Q35345363-BDE6C4DC-BDDF-4591-A857-FF131FB1DF23

P577

Q35345363-60A06954-0495-4EC4-8874-201CEB46967B

P5875

Q35345363-9F1D4CAF-8B78-4A2B-95BD-E4460A33C976

P698

Q35345363-EB5276A8-1C99-4269-A118-9D4F34FC0C64

P932

Q35345363-A70731C5-8DE4-4603-8BBC-C90D6775E3D0

P356

SCITRANSLMED.3003936

P1433

Science Translational Medicine

P1476

An intravaginal ring that rele ...... SHIV transmission in macaques

@en

P2093

Agegnehu Gettie

http://www.w3.org/2001/XMLSchema#string

Aixa Rodriguez

http://www.w3.org/2001/XMLSchema#string

Daniel Goldman

http://www.w3.org/2001/XMLSchema#string

James Blanchard

http://www.w3.org/2001/XMLSchema#string

Jeffrey D Lifson

http://www.w3.org/2001/XMLSchema#string

Jessica Kenney

http://www.w3.org/2001/XMLSchema#string

José A Fernández-Romero

http://www.w3.org/2001/XMLSchema#string

Larisa Kizima

http://www.w3.org/2001/XMLSchema#string

Melissa Robbiani

http://www.w3.org/2001/XMLSchema#string

Meropi Aravantinou

http://www.w3.org/2001/XMLSchema#string

P2860

Efficacy of Carraguard-based microbicides in vivo despite variable in vitro activity

Effectiveness and safety of tenofovir gel, an antiretroviral microbicide, for the prevention of HIV infection in women

A macaque model to study vaginal HSV-2/immunodeficiency virus co-infection and the impact of HSV-2 on microbicide efficacy

An antiretroviral/zinc combination gel provides 24 hours of complete protection against vaginal SHIV infection in macaques

Delay of simian human immunodeficiency virus infection and control of viral replication in vaccinated macaques challenged in the presence of a topical microbicide.

A vaginal fluid simulant.

Identification of personal lubricants that can cause rectal epithelial cell damage and enhance HIV type 1 replication in vitro

Infectious and whole inactivated simian immunodeficiency viruses interact similarly with primate dendritic cells (DCs): differential intracellular fate of virions in mature and immature DCs

Compartmental transport model of microbicide delivery by an intravaginal ring.

The nonnucleoside reverse transcriptase inhibitor MIV-150 in carrageenan gel prevents rectal transmission of simian/human immunodeficiency virus infection in macaques.

P304

150ra123

http://www.w3.org/2001/XMLSchema#string

P31

scholarly article

P356

10.1126/SCITRANSLMED.3003936

http://www.w3.org/2001/XMLSchema#string

P407

P433

150

http://www.w3.org/2001/XMLSchema#string

P478

4

http://www.w3.org/2001/XMLSchema#string

P577

2012-09-01T00:00:00Z

http://www.w3.org/2001/XMLSchema#dateTime

P5875

230811506

http://www.w3.org/2001/XMLSchema#string

P698

22956201

http://www.w3.org/2001/XMLSchema#string

P932

4391747

http://www.w3.org/2001/XMLSchema#string