Activated mTORC1 promotes long-term cone survival in retinitis pigmentosa mice. - Wikidata - awgldk - TriplyDB

Activated mTORC1 promotes long-term cone survival in retinitis pigmentosa mice.

Activated mTORC1 promotes long-term cone survival in retinitis pigmentosa mice.

http://www.wikidata.org/entity/Q35409026

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Exploiting metabolic and antioxidant pathways to maintain vision in blinding disease Glycolytic reliance promotes anabolism in photoreceptors.Improved cell metabolism prolongs photoreceptor survival upon retinal-pigmented epithelium loss in the sodium iodate induced model of geographic atrophy Advances in Gene Therapy for Diseases of the Eye.TSC but not PTEN loss in starving cones of retinitis pigmentosa mice leads to an autophagy defect and mTORC1 dissociation from the lysosome.The Warburg Effect Mediator Pyruvate Kinase M2 Expression and Regulation in the Retina.Reprogramming metabolism by targeting sirtuin 6 attenuates retinal degeneration.Gene therapy approaches for the treatment of retinal disorders Nrl knockdown by AAV-delivered CRISPR/Cas9 prevents retinal degeneration in mice.HDAC inhibition in the cpfl1 mouse protects degenerating cone photoreceptors in vivo.A review of the mechanisms of cone degeneration in retinitis pigmentosa.Metabolic and redox signaling in the retina.Glucose metabolism in mammalian photoreceptor inner and outer segments.Quantifying the metabolic contribution to photoreceptor death in retinitis pigmentosa via a mathematical model.Loss of mTOR signaling affects cone function, cone structure and expression of cone specific proteins without affecting cone survival.Reprogramming towards anabolism impedes degeneration in a preclinical model of retinitis pigmentosa.Biochemical adaptations of the retina and retinal pigment epithelium support a metabolic ecosystem in the vertebrate eye.mTORC1 sustains vision in retinitis pigmentosa.Loss of the cone-enriched caspase-7 does not affect secondary cone death in retinitis pigmentosa.CRISPR in the Retina: Evaluation of Future Potential.Reprogramming the metabolome rescues retinal degeneration.Developmental and light regulation of tumor suppressor protein PP2A in the retina.Cell metabolism: Sugar for sight.Aerobic Glycolysis Is Essential for Normal Rod Function and Controls Secondary Cone Death in Retinitis Pigmentosa.Ribosomal protein S6 kinase 1 promotes the survival of photoreceptors in retinitis pigmentosa

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P2860

Activated mTORC1 promotes long-term cone survival in retinitis pigmentosa mice.

http://www.wikidata.org/entity/Q35409026

description

2015 nî lūn-bûn

@nan

2015 թուականի Մարտին հրատարակուած գիտական յօդուած

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2015 թվականի մարտին հրատարակված գիտական հոդված

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2015年の論文

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2015年論文

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2015年論文

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2015年論文

@zh-hk

2015年論文

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2015年論文

@zh-tw

2015年论文

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name

Activated mTORC1 promotes long-term cone survival in retinitis pigmentosa mice.

@ast

Activated mTORC1 promotes long-term cone survival in retinitis pigmentosa mice.

@en

type

label

Activated mTORC1 promotes long-term cone survival in retinitis pigmentosa mice.

@ast

Activated mTORC1 promotes long-term cone survival in retinitis pigmentosa mice.

@en

prefLabel

Activated mTORC1 promotes long-term cone survival in retinitis pigmentosa mice.

@ast

Activated mTORC1 promotes long-term cone survival in retinitis pigmentosa mice.

@en

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P1433

Journal of Clinical Investigation

P1476

Activated mTORC1 promotes long-term cone survival in retinitis pigmentosa mice.

@en

P2093

Aditya Venkatesh

http://www.w3.org/2001/XMLSchema#string

Claudio Punzo

http://www.w3.org/2001/XMLSchema#string

Markus A Rüegg

http://www.w3.org/2001/XMLSchema#string

Michael N Hall

http://www.w3.org/2001/XMLSchema#string

Shan Ma

http://www.w3.org/2001/XMLSchema#string

Yun Z Le

http://www.w3.org/2001/XMLSchema#string

P2860

Hexokinase II: cancer's double-edged sword acting as both facilitator and gatekeeper of malignancy when bound to mitochondria

mTOR: from growth signal integration to cancer, diabetes and ageing

Characterization of Rictor phosphorylation sites reveals direct regulation of mTOR complex 2 by S6K1

HIF-1: upstream and downstream of cancer metabolism

Site-specific DNA recombination in mammalian cells by the Cre recombinase of bacteriophage P1

mTOR-dependent cell survival mechanisms

Mammalian caspases: structure, activation, substrates, and functions during apoptosis

A mouse model of TSC1 reveals sex-dependent lethality from liver hemangiomas, and up-regulation of p70S6 kinase activity in Tsc1 null cells

Ablation in mice of the mTORC components raptor, rictor, or mLST8 reveals that mTORC2 is required for signaling to Akt-FOXO and PKCalpha, but not S6K1

Activation of a metabolic gene regulatory network downstream of mTOR complex 1

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1446-1458

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scholarly article

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10.1172/JCI79766

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4

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125

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2015-03-23T00:00:00Z

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25798619

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4396488

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